Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis Article Swipe
Bana Jabrì
,
Dustin G. Shaw
,
Raúl Aguirre‐Gamboa
,
Marcos Vieria
,
Saideep Gona
,
Nicholas DiNardi
,
Anni Wang
,
Anne Dumaine
,
Jody Gederloos
,
Zachary M. Earley
,
Katherine Meckel
,
Cezary Ciszewski
,
Anabella Castillo
,
Kelly Monroe
,
Joana Torres
,
Shailja C. Shah
,
Jean‐Frédéric Colombel
,
Steven H. Itzkowitz
,
Rodney D. Newberry
,
Russell D. Cohen
,
David T. Rubin
,
Sarah Cobey
,
Iris H. Jonkers
,
Christopher R. Weber
,
Joel Pekow
,
Patrick C. Wilson
,
Luis B. Barreiro
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-1697242/v1
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-1697242/v1
Primary sclerosing cholangitis (PSC) is an autoimmune-like disease of the bile ducts that co-occurs with inflammatory bowel disease (IBD) in almost 90% of cases. Colorectal cancer is a major complication of patients with both PSC and IBD, and these patients are at a much greater risk compared to patients with IBD without concomitant PSC. Combining flow cytometry, bulk and single cell transcriptomics, and T- and B-cell receptor repertoire analysis of right colon tissue from PSC, IBD, and healthy controls we identified a unique adaptive inflammatory transcriptional signature associated with greater risk and shorter time to dysplasia specifically in patients with PSC. This inflammatory signature is characterized by antigen-driven IL-17A+ Foxp3+ CD4 T-cell and IgG-secreting B-cell responses. These data suggest that the mechanisms of PSC and IBD dysplasia are distinct and provide molecular insights to guide prevention of colorectal cancer in PSC.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-1697242/v1
- https://www.researchsquare.com/article/rs-1697242/latest.pdf
- OA Status
- green
- References
- 34
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4281622732
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4281622732Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-1697242/v1Digital Object Identifier
- Title
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Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitisWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-06-01Full publication date if available
- Authors
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Bana Jabrì, Dustin G. Shaw, Raúl Aguirre‐Gamboa, Marcos Vieria, Saideep Gona, Nicholas DiNardi, Anni Wang, Anne Dumaine, Jody Gederloos, Zachary M. Earley, Katherine Meckel, Cezary Ciszewski, Anabella Castillo, Kelly Monroe, Joana Torres, Shailja C. Shah, Jean‐Frédéric Colombel, Steven H. Itzkowitz, Rodney D. Newberry, Russell D. Cohen, David T. Rubin, Sarah Cobey, Iris H. Jonkers, Christopher R. Weber, Joel Pekow, Patrick C. Wilson, Luis B. BarreiroList of authors in order
- Landing page
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https://doi.org/10.21203/rs.3.rs-1697242/v1Publisher landing page
- PDF URL
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https://www.researchsquare.com/article/rs-1697242/latest.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://www.researchsquare.com/article/rs-1697242/latest.pdfDirect OA link when available
- Concepts
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Primary sclerosing cholangitis, Inflammation, Dysplasia, Medicine, Primary (astronomy), Gastroenterology, Immunology, Internal medicine, Disease, Physics, AstronomyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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34Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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