Antimicrobial 3D printed implants for periprosthetic joint infections Article Swipe
Iván Yuste
,
Francis C. Luciano
,
Carmina Rodríguez Fernández
,
Bianca I. Ramirez
,
Chrysi Rapti
,
Brayan J. Anaya
,
Aikaterini Lalatsa
,
Almudena Ribed
,
Pablo Sanz-Ruíz
,
Elena González‐Burgos
,
Dolores R. Serrano
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1007/s13346-025-01934-5
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1007/s13346-025-01934-5
Periprosthetic joint infections (PJIs) remain a serious complication following hip and knee arthroplasty, affecting 1–5% of patients in developed countries and posing significant challenges to patients, clinicians, and healthcare systems. Conventional prophylactic strategies, such as antibiotic-loaded bone cement, suffer from limited post-implantation drug release and potential compromise of mechanical integrity. To overcome these limitations, we developed a personalized, 3D-printed implant designed to integrate with the acetabular component of joint prostheses. These implants deliver either monotherapy or a combination of amphotericin B (AmB) and vancomycin (VAN), targeting both fungal and bacterial pathogens. Fabricated via fused deposition modeling using a biocompatible polyvinyl alcohol–polyethylene glycol (PVA–PEG) matrix, the implants enable passive drug loading and rapid adhesion to prosthetic surfaces within 60 s, minimizing operative time. In vitro testing confirmed broad-spectrum antimicrobial activity against Candida spp. ( C. albicans , C. parapsilosis , C. glabrata , C. krusei ) and Staphylococcus spp. ( S. aureus , S. epidermidis ). VAN was released rapidly, while AmB exhibited sustained release for up to 10 h, with both maintaining saturation solubility for 48 h. Notably, AmB-loaded implants showed five-fold lower hemolytic toxicity compared to free drug. These results highlight the potential of 3D-printed, drug-eluting implants as a clinically viable solution for the prevention and early treatment of PJIs. Graphical abstract
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1007/s13346-025-01934-5
- OA Status
- hybrid
- References
- 70
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4413140206Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1007/s13346-025-01934-5Digital Object Identifier
- Title
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Antimicrobial 3D printed implants for periprosthetic joint infectionsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-08-14Full publication date if available
- Authors
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Iván Yuste, Francis C. Luciano, Carmina Rodríguez Fernández, Bianca I. Ramirez, Chrysi Rapti, Brayan J. Anaya, Aikaterini Lalatsa, Almudena Ribed, Pablo Sanz-Ruíz, Elena González‐Burgos, Dolores R. SerranoList of authors in order
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https://doi.org/10.1007/s13346-025-01934-5Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1007/s13346-025-01934-5Direct OA link when available
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Periprosthetic, Joint infections, Antimicrobial, Medicine, 3d printed, Joint (building), Arthroplasty, Surgery, Biomedical engineering, Microbiology, Biology, Engineering, Architectural engineeringTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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70Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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