Antimicrobial Dosing During Continuous Venovenous Hemodiafiltration in Septic Shock Patients: A Prospective, Multicenter Study Protocol Article Swipe
Alicia Wendy Vega Harwood
,
Marta Fernández‐González
,
Carlos Ezquer
,
E. Alvarez
,
Rocío López-Herrero
,
Eduardo Tamayo
,
Gerardo Aguilar
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/antibiotics14040420
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/antibiotics14040420
Background: Sepsis is a major global health issue and the leading cause of death in critically ill patients, with rising incidence and associated healthcare costs. Early administration of antibiotic therapy is crucial, but increasing antibiotic resistance poses a threat. Beta-lactam antibiotics, commonly used as a first-line therapy option against sepsis, often demonstrate unpredictable concentrations due to pharmacokinetic and pharmacodynamic changes in critically ill patients. Acute kidney injury (AKI) affects a significant portion of septic patients, and continuous renal replacement therapy can further complicate treatment by reducing antibiotic levels and, consequently, increasing antibiotic resistance risk. Objectives: To develop pharmacokinetic/pharmacodynamic models for beta-lactam antibiotics in septic shock patients undergoing continuous renal replacement therapy (CRRT), with the goal of optimizing antibiotic dosing and then improving treatment outcomes. Methods: Septic shock Caucasian adult patients treated with beta-lactams and who have undergone major surgery in AKI failure that requires CRRT will be eligible with previous informed written consent. CRRT will be performed exclusively using Continuous Venovenous Hemodiafiltration (CVVHDF) modality. Antimicrobial determination analyses will be carried out with LC-MS/MS. Further calculation of pharmacokinetic parameters and determination of PK/PD breakpoints will be made using Monte Carlo simulation. Conclusions: The expected results from this study will lead to a better understanding of the pharmacokinetics of beta-lactam antibiotics in critically ill patients with AKI and septic shock undergoing CVVHDF, allowing for improved therapeutic strategies.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/antibiotics14040420
- https://www.mdpi.com/2079-6382/14/4/420/pdf?version=1745235039
- OA Status
- gold
- References
- 51
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409634924
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4409634924Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/antibiotics14040420Digital Object Identifier
- Title
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Antimicrobial Dosing During Continuous Venovenous Hemodiafiltration in Septic Shock Patients: A Prospective, Multicenter Study ProtocolWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-04-21Full publication date if available
- Authors
-
Alicia Wendy Vega Harwood, Marta Fernández‐González, Carlos Ezquer, E. Alvarez, Rocío López-Herrero, Eduardo Tamayo, Gerardo AguilarList of authors in order
- Landing page
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https://doi.org/10.3390/antibiotics14040420Publisher landing page
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https://www.mdpi.com/2079-6382/14/4/420/pdf?version=1745235039Direct link to full text PDF
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
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https://www.mdpi.com/2079-6382/14/4/420/pdf?version=1745235039Direct OA link when available
- Concepts
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Medicine, Septic shock, Renal replacement therapy, Dosing, Intensive care medicine, Acute kidney injury, Pharmacodynamics, Sepsis, Antibiotics, Pharmacokinetics, Intensive care, Internal medicine, Biology, MicrobiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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51Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.Caucasian | 127 |
| abstract_inverted_index.LC-MS/MS. | 172 |
| abstract_inverted_index.improving | 121 |
| abstract_inverted_index.incidence | 20 |
| abstract_inverted_index.modality. | 163 |
| abstract_inverted_index.outcomes. | 123 |
| abstract_inverted_index.patients, | 17, 74 |
| abstract_inverted_index.patients. | 63 |
| abstract_inverted_index.performed | 156 |
| abstract_inverted_index.treatment | 83, 122 |
| abstract_inverted_index.undergone | 136 |
| abstract_inverted_index.Continuous | 159 |
| abstract_inverted_index.Venovenous | 160 |
| abstract_inverted_index.antibiotic | 28, 34, 86, 91, 117 |
| abstract_inverted_index.associated | 22 |
| abstract_inverted_index.complicate | 82 |
| abstract_inverted_index.continuous | 76, 107 |
| abstract_inverted_index.critically | 15, 61, 210 |
| abstract_inverted_index.first-line | 45 |
| abstract_inverted_index.healthcare | 23 |
| abstract_inverted_index.increasing | 33, 90 |
| abstract_inverted_index.optimizing | 116 |
| abstract_inverted_index.parameters | 177 |
| abstract_inverted_index.resistance | 35, 92 |
| abstract_inverted_index.undergoing | 106, 218 |
| abstract_inverted_index.Background: | 0 |
| abstract_inverted_index.Beta-lactam | 39 |
| abstract_inverted_index.Objectives: | 94 |
| abstract_inverted_index.antibiotics | 101, 208 |
| abstract_inverted_index.beta-lactam | 100, 207 |
| abstract_inverted_index.breakpoints | 182 |
| abstract_inverted_index.calculation | 174 |
| abstract_inverted_index.demonstrate | 51 |
| abstract_inverted_index.exclusively | 157 |
| abstract_inverted_index.replacement | 78, 109 |
| abstract_inverted_index.significant | 70 |
| abstract_inverted_index.simulation. | 189 |
| abstract_inverted_index.strategies. | 224 |
| abstract_inverted_index.therapeutic | 223 |
| abstract_inverted_index.Conclusions: | 190 |
| abstract_inverted_index.antibiotics, | 40 |
| abstract_inverted_index.beta-lactams | 132 |
| abstract_inverted_index.Antimicrobial | 164 |
| abstract_inverted_index.consequently, | 89 |
| abstract_inverted_index.determination | 165, 179 |
| abstract_inverted_index.understanding | 202 |
| abstract_inverted_index.unpredictable | 52 |
| abstract_inverted_index.administration | 26 |
| abstract_inverted_index.concentrations | 53 |
| abstract_inverted_index.pharmacodynamic | 58 |
| abstract_inverted_index.pharmacokinetic | 56, 176 |
| abstract_inverted_index.pharmacokinetics | 205 |
| abstract_inverted_index.Hemodiafiltration | 161 |
| abstract_inverted_index.pharmacokinetic/pharmacodynamic | 97 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8100000023841858 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.15285089 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |