Antinociceptive and anti-inflammatory effect of Lippia pedunculosa Hayek essential oil and its β-cyclodextrin inclusion complex Article Swipe
Renan Marinho Braga
,
Humberto Hugo Nunes de Andrade
,
Humberto de Carvalho Aragão Neto
,
Ryldene Marques Duarte da Cruz
,
Davidson Barbosa Assis
,
Luiz Henrique Agra
,
Sandra Rodrigues‐Mascarenhas
,
Liana Clébia de Morais Pordeus
,
Lucindo José Quintans‐Júnior
,
Reinaldo Nóbrega de Almeida
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.37360/blacpma.21.20.2.13
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.37360/blacpma.21.20.2.13
Lippia pedunculosa Hayek (EOLp) presents tripanocid and amebicid effects. However essential oil needs to be further studied in experimental models of analgesia and inflammation once the prevalence of pain in the population generates great suffering and disability and the drugs most often used have undesirable side effects. We also evaluated whether the inclusion complex formulation EOLp/β-cyclodextrin (β-CD) was able to improve the antinociceptive activity of the EOLp alone. Data were evaluated by analysis of variance (ANOVA), followed by Tukey’s test. Differences were considered significant if p<0.05. EOLp presented better antinociceptive effect when compared to the EOLp/β-CD inclusion complex. Thus, cyclodextrins appear not to be efficient for essential oils with peroxide substances. However, in peritonitis, EOLp reduced total leucocyte migration and IL-1β levels in the peritoneal fluid, which confirmed its anti-inflammatory effect. The observed effects suggest that EOLp is the best promising option for the treatment of inflammation and pain-related disorders.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.37360/blacpma.21.20.2.13
- https://www.blacpma.ms-editions.cl/index.php/blacpma/article/download/140/136/268
- OA Status
- diamond
- Cited By
- 2
- References
- 79
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3121725024
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3121725024Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.37360/blacpma.21.20.2.13Digital Object Identifier
- Title
-
Antinociceptive and anti-inflammatory effect of Lippia pedunculosa Hayek essential oil and its β-cyclodextrin inclusion complexWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-03-30Full publication date if available
- Authors
-
Renan Marinho Braga, Humberto Hugo Nunes de Andrade, Humberto de Carvalho Aragão Neto, Ryldene Marques Duarte da Cruz, Davidson Barbosa Assis, Luiz Henrique Agra, Sandra Rodrigues‐Mascarenhas, Liana Clébia de Morais Pordeus, Lucindo José Quintans‐Júnior, Reinaldo Nóbrega de AlmeidaList of authors in order
- Landing page
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https://doi.org/10.37360/blacpma.21.20.2.13Publisher landing page
- PDF URL
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https://www.blacpma.ms-editions.cl/index.php/blacpma/article/download/140/136/268Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
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https://www.blacpma.ms-editions.cl/index.php/blacpma/article/download/140/136/268Direct OA link when available
- Concepts
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Lippia, Nociception, Essential oil, Cyclodextrin, Traditional medicine, Medicine, Population, Pharmacology, Chemistry, Internal medicine, Food science, Chromatography, Environmental health, ReceptorTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
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2022: 1, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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79Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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