Antioxidant Activity and Genotoxic Assessment of Crabwood (Andiroba, Carapa guianensis Aublet) Seed Oils Article Swipe
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· 2018
· Open Access
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· DOI: https://doi.org/10.1155/2018/3246719
The seed oil of Carapa guianensis (Aublet), a tree from the Meliaceae family commonly known as andiroba, is widely used in Brazilian traditional medicine because of its multiple curative properties against fever and rheumatism and as an anti‐inflammatory agent, antibacterial agent, and insect repellant. Since there is no consensus on the best way to obtain the C. guianensis oil and due to its ethnomedicinal properties, the aim of the present research was to evaluate the chemical composition, free‐radical scavenging activity, and mutagenic and genotoxicity properties of three C. guianensis oils obtained by different extraction methods. The phenolic contents were evaluated by spectrophotometry. Oil 1 was obtained by pressing the dried seeds at room temperature; oil 2 was obtained by autoclaving, drying, and pressing; oil 3 was obtained by Soxhlet extraction at 30–60°C using petroleum ether. The oil from each process presented differential yields, physicochemical properties, and phenolic contents. Oil 1 showed a higher scavenging activity against the DPPH radical when compared to oils 2 and 3, suggesting a significant antioxidant activity. All oils were shown to be cytotoxic to bacteria and to CHO‐K1 and RAW264.7 cells. At noncytotoxic concentrations, oil 2 presented mutagenicity to Salmonella enterica serovar Typhimurium and induced micronuclei in both cell types. Under the same conditions, oil 3 also induced micronucleus formation. However, the present data demonstrated that oil 1, extracted without using high temperatures, was the safest for use as compared to the other two oils, not showing mutagenicity or micronucleus induction.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1155/2018/3246719
- http://downloads.hindawi.com/journals/omcl/2018/3246719.pdf
- OA Status
- hybrid
- Cited By
- 37
- References
- 43
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2801137651
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2801137651Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1155/2018/3246719Digital Object Identifier
- Title
-
Antioxidant Activity and Genotoxic Assessment of Crabwood (Andiroba, Carapa guianensis Aublet) Seed OilsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-01-01Full publication date if available
- Authors
-
Carlos Fernando Araújo-Lima, Andréia da Silva Fernandes, Erika M. Gomes, Larisse L. Oliveira, Andrea Furtado Macedo, Rosemar Antoniassi, Allan Eduardo Wilhelm, Cláudia Alessandra Fortes Aiub, Israel FelzenszwalbList of authors in order
- Landing page
-
https://doi.org/10.1155/2018/3246719Publisher landing page
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https://downloads.hindawi.com/journals/omcl/2018/3246719.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
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https://downloads.hindawi.com/journals/omcl/2018/3246719.pdfDirect OA link when available
- Concepts
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Botany, Traditional medicine, Chemistry, Biology, MedicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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37Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 6, 2023: 10, 2022: 5, 2021: 5Per-year citation counts (last 5 years)
- References (count)
-
43Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.properties | 29, 84 |
| abstract_inverted_index.repellant. | 43 |
| abstract_inverted_index.rheumatism | 33 |
| abstract_inverted_index.scavenging | 78, 153 |
| abstract_inverted_index.suggesting | 166 |
| abstract_inverted_index.Typhimurium | 197 |
| abstract_inverted_index.antioxidant | 169 |
| abstract_inverted_index.conditions, | 208 |
| abstract_inverted_index.micronuclei | 200 |
| abstract_inverted_index.properties, | 64, 144 |
| abstract_inverted_index.significant | 168 |
| abstract_inverted_index.traditional | 22 |
| abstract_inverted_index.autoclaving, | 119 |
| abstract_inverted_index.composition, | 76 |
| abstract_inverted_index.demonstrated | 219 |
| abstract_inverted_index.differential | 141 |
| abstract_inverted_index.genotoxicity | 83 |
| abstract_inverted_index.micronucleus | 213, 244 |
| abstract_inverted_index.mutagenicity | 192, 242 |
| abstract_inverted_index.noncytotoxic | 187 |
| abstract_inverted_index.temperature; | 113 |
| abstract_inverted_index.antibacterial | 39 |
| abstract_inverted_index.temperatures, | 227 |
| abstract_inverted_index.ethnomedicinal | 63 |
| abstract_inverted_index.free‐radical | 77 |
| abstract_inverted_index.concentrations, | 188 |
| abstract_inverted_index.physicochemical | 143 |
| abstract_inverted_index.spectrophotometry. | 101 |
| abstract_inverted_index.anti‐inflammatory | 37 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5052267810 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I40034438 |
| citation_normalized_percentile.value | 0.80290673 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |