Antioxidant and hepatorenal protective effects of bee pollen fractions against propionic acid‐induced autistic feature in rats Article Swipe
Huda Salem AlSalem
,
Hanan M. Al‐Yousef
,
Abdelkader E. Ashour
,
Atallah F. Ahmed
,
Musarat Amina
,
Iman S. Issa
,
Ramesa Shafi Bhat
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1002/fsn3.1813
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1002/fsn3.1813
In the brain, propionic acid (PA) can cross cell membranes and accumulate within cells, leading to intracellular acidification, which may alter neurotransmitter release (NT), communication between neurons, and behavior. Such elevation in levels of PA constitutes a neurodevelopmental metabolic disorder called propionic acidemia, which could clinically manifest as autism. The purpose of this study was to investigate the protective effects of different fractions of bee pollen (BP) on PA‐induced autism in rats, and to evaluate their effects on the expression of liver and renal biomarkers. Groups of rats received treatments of different fractions of BP at a dose of 250 mg/kg of body weight/day for a period of 1 month. Normal control group I and group II were orally administered with phosphate‐buffered saline and propionic acid, respectively, for 3 days. BP contains various health‐promoting phenolic components. Different fractions of BP administered pre‐ and post‐treatment with PA showed significant reduction in the levels of liver and renal biomarkers ( p < .05). Also, a significant enhancement in the levels of glutathione S‐transferase (GST), catalase CAT), and ascorbic acid (VIT C) was observed. Supplementation with BP significantly reduced biochemical changes in the liver, kidneys, and brain of rats with PA‐induced toxicity. It exhibited protective effects against oxidative damage and reactive oxygen species produced by PA‐induced adverse reactions in rats. Taken together, our study shows that BP possesses protective effects in PA‐induced liver and kidney damage.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/fsn3.1813
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/fsn3.1813
- OA Status
- hybrid
- Cited By
- 15
- References
- 69
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3049685810
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3049685810Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/fsn3.1813Digital Object Identifier
- Title
-
Antioxidant and hepatorenal protective effects of bee pollen fractions against propionic acid‐induced autistic feature in ratsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-08-14Full publication date if available
- Authors
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Huda Salem AlSalem, Hanan M. Al‐Yousef, Abdelkader E. Ashour, Atallah F. Ahmed, Musarat Amina, Iman S. Issa, Ramesa Shafi BhatList of authors in order
- Landing page
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https://doi.org/10.1002/fsn3.1813Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/fsn3.1813Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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-
hybridOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/fsn3.1813Direct OA link when available
- Concepts
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Antioxidant, Ascorbic acid, Glutathione, Oxidative stress, Chemistry, Pharmacology, Catalase, Kidney, Endocrinology, Internal medicine, Reactive oxygen species, Toxicity, Biochemistry, Medicine, Enzyme, Food scienceTop concepts (fields/topics) attached by OpenAlex
- Cited by
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15Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 1, 2023: 4, 2022: 4, 2021: 3Per-year citation counts (last 5 years)
- References (count)
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69Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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