Antisense Oligonucleotides Selectively Enter Human‐Derived Antibiotic‐Resistant Bacteria through Bacterial‐Specific ATP‐Binding Cassette Sugar Transporter Article Swipe
Mingzhu Liu
,
Binbin Chu
,
Rong Sun
,
Jiali Ding
,
Han Ye
,
Yunmin Yang
,
Yuqi Wu
,
Haoliang Shi
,
Bin Song
,
Yao He
,
Houyu Wang
,
Jiaxu Hong
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/adma.202300477
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/adma.202300477
Current vehicles used to deliver antisense oligonucleotides (ASOs) cannot distinguish between bacterial and mammalian cells, greatly hindering the preclinical or clinical treatment of bacterial infections, especially those caused by antibiotic‐resistant bacteria. Herein, bacteria‐specific ATP‐binding cassette (ABC) sugar transporters are leveraged to selectively internalize ASOs by hitchhiking them on α (1–4)‐glucosidically linked glucose polymers. Compared with their cell‐penetrating peptide counterparts, which are non‐specifically engulfed by mammalian and bacterial cells, the presented therapeutics consisting of glucose polymer and antisense peptide nucleic‐acid‐modified nanoparticles are selectively internalized into the human‐derived multidrug‐resistant Escherichia coli and methicillin‐resistant Staphylococcus aureus , and they display a much higher uptake rate (i.e., 51.6%). The developed strategy allows specific and efficient killing of nearly 100% of the antibiotic‐resistant bacteria. Its significant curative efficacy against bacterial keratitis and endophthalmitis is also shown. This strategy will expand the focus of antisense technology to include bacterial cells other than mammalian cells.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/adma.202300477
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adma.202300477
- OA Status
- bronze
- Cited By
- 28
- References
- 60
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4362450322
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4362450322Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/adma.202300477Digital Object Identifier
- Title
-
Antisense Oligonucleotides Selectively Enter Human‐Derived Antibiotic‐Resistant Bacteria through Bacterial‐Specific ATP‐Binding Cassette Sugar TransporterWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-04-01Full publication date if available
- Authors
-
Mingzhu Liu, Binbin Chu, Rong Sun, Jiali Ding, Han Ye, Yunmin Yang, Yuqi Wu, Haoliang Shi, Bin Song, Yao He, Houyu Wang, Jiaxu HongList of authors in order
- Landing page
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https://doi.org/10.1002/adma.202300477Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adma.202300477Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adma.202300477Direct OA link when available
- Concepts
-
Bacteria, Microbiology, Escherichia coli, Oligonucleotide, Antibiotics, Staphylococcus aureus, Biology, Peptide, Bacterial cell structure, Nucleic acid, Biochemistry, Gene, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
28Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 12, 2024: 15, 2023: 1Per-year citation counts (last 5 years)
- References (count)
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60Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| corresponding_author_ids | https://openalex.org/A5064608517, https://openalex.org/A5033893564, https://openalex.org/A5054439790 |
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