Antithrombotic Effect of Chenopodium album L. Extract and Its Fractions via Regulating TLRs and the Downstream MAPKs and PI3K/AKT Signaling Pathways in Zebrafish Article Swipe
Xiyue Wang
,
Miaoyunhuan Wang
,
Yuqing Dong
,
Shuqing Yu
,
Shanshan Zhang
,
Pinghua Sun
,
Lu Wang
,
Jibin Liu
,
Hou‐Wen Lin
,
Xinhui Pan
,
Xiaobin Li
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/ijms26052118
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/ijms26052118
Chenopodium album L., as a folkloric herb, is traditionally used to treat poisonous insect bites, vitiligo, and other ailments. However, its impact on thrombosis remains unknown. In this study, we discovered that the ethanol extract of C. album exhibited a remarkable antithrombotic effect using a zebrafish thrombosis model for the first time. Activity evaluation showed that fraction CA-C could improve thrombus aggregation in the caudal vein, increase blood return in the heart, and alleviate the slowing of blood flow compared with those in the model group. Then, analysis by ultra-high performance liquid chromatography-quadrupole time-of-flight tandem mass (UPLC-Q-TOF-MS) identified 58 constituents of CA-C, with most of them belonging to flavonoids, alkaloids, and steroidal saponin components. Moreover, using a comprehensive strategy of network pharmacological analysis, transcriptomic assay, and RT-qPCR validation, we found that CA-C could mediate the TLR’s signaling pathway and its downstream MAPKs and PI3K/AKT signaling pathways to exert an antithrombotic effect. This study broadens the clinical application of plant C. album and provides new insight into the chemical profile, pharmacodynamics, and potential mechanisms of CA-C as candidate agents for treating thrombosis.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms26052118
- https://www.mdpi.com/1422-0067/26/5/2118/pdf?version=1740658078
- OA Status
- gold
- Cited By
- 1
- References
- 39
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408017851
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https://openalex.org/W4408017851Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ijms26052118Digital Object Identifier
- Title
-
Antithrombotic Effect of Chenopodium album L. Extract and Its Fractions via Regulating TLRs and the Downstream MAPKs and PI3K/AKT Signaling Pathways in ZebrafishWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-02-27Full publication date if available
- Authors
-
Xiyue Wang, Miaoyunhuan Wang, Yuqing Dong, Shuqing Yu, Shanshan Zhang, Pinghua Sun, Lu Wang, Jibin Liu, Hou‐Wen Lin, Xinhui Pan, Xiaobin LiList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms26052118Publisher landing page
- PDF URL
-
https://www.mdpi.com/1422-0067/26/5/2118/pdf?version=1740658078Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1422-0067/26/5/2118/pdf?version=1740658078Direct OA link when available
- Concepts
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PI3K/AKT/mTOR pathway, Zebrafish, Downstream (manufacturing), Protein kinase B, Signal transduction, Cell biology, Biology, Chemistry, Biochemistry, Gene, Operations management, EconomicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1Per-year citation counts (last 5 years)
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39Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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