Antiviral Compounds from Natural Sources Against Human Arboviruses: An Updated Review Including Illustrative In Silico Analysis Article Swipe
Julio Aguiar-Pech
,
Rocio Borges Argaez
,
Henry Puerta-Guardo
,
Julio Aguiar-Pech
,
Rocio Borges Argaez
,
Henry Puerta-Guardo
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/pathogens14111156
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/pathogens14111156
Arboviruses such as dengue (DENV), Zika (ZIKV), and chikungunya (CHIKV) remain major global health threats, especially in tropical regions, with no effective antiviral treatments available. Recent research highlights progress in identifying antiviral compounds from natural sources against arboviruses belonging to the flavivirus genus, such as DENV and ZIKV. These compounds, derived from plants, marine organisms, and microorganisms, fall into several key chemical classes: quinones, flavonoids, phenolics, terpenoids, and alkaloids. Quinones inhibit viral entry and replication by targeting envelope proteins and proteases. Flavonoids disrupt RNA synthesis and show virucidal activity. Phenolic compounds reduce expression of non-structural proteins and inhibit enzyme function. Terpenoids demonstrate broad-spectrum activity against multiple arboviruses, while alkaloids interfere with early infection stages or viral enzymes. To support the reviewed literature, we performed molecular docking analyses of selected natural compounds and some arboviral proteins included as illustrative examples. These analyses support the structure–activity relationships reported for some natural compounds and highlight their potential interactions with essential viral targets such as the NS2B-NS3 protease and NS5 polymerase. Together, these literature and computational insights highlight the potential of natural products as scaffolds for antiviral drug development.
Related Topics
Concepts
In silico
Flavivirus
Dengue virus
Chikungunya
Dengue fever
Computational biology
Biology
Drug discovery
Flaviviridae
Virology
Antiviral drug
Viral replication
NS3
Zika virus
Drug
RNA
Docking (animal)
Andrographolide
Protease
Natural product
Human health
Virus
Viral envelope
Chemical space
Chemistry
Drug development
Pharmacophore
Chemical biology
Human use
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/pathogens14111156
- https://www.mdpi.com/2076-0817/14/11/1156/pdf?version=1763034446
- OA Status
- gold
- References
- 54
- OpenAlex ID
- https://openalex.org/W7105611536
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W7105611536Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/pathogens14111156Digital Object Identifier
- Title
-
Antiviral Compounds from Natural Sources Against Human Arboviruses: An Updated Review Including Illustrative In Silico AnalysisWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-11-13Full publication date if available
- Authors
-
Julio Aguiar-Pech, Rocio Borges Argaez, Henry Puerta-Guardo, Julio Aguiar-Pech, Rocio Borges Argaez, Henry Puerta-GuardoList of authors in order
- Landing page
-
https://doi.org/10.3390/pathogens14111156Publisher landing page
- PDF URL
-
https://www.mdpi.com/2076-0817/14/11/1156/pdf?version=1763034446Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://www.mdpi.com/2076-0817/14/11/1156/pdf?version=1763034446Direct OA link when available
- Concepts
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In silico, Flavivirus, Dengue virus, Chikungunya, Dengue fever, Computational biology, Biology, Drug discovery, Flaviviridae, Virology, Antiviral drug, Viral replication, NS3, Zika virus, Drug, RNA, Docking (animal), Andrographolide, Protease, Natural product, Human health, Virus, Viral envelope, Chemical space, Chemistry, Drug development, Pharmacophore, Chemical biology, Human useTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
54Number of works referenced by this work
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