Aplicação das Células-Tronco da Polpa Dentária na Regeneração Óssea: Uma Análise da Literatura Científica Article Swipe

PDF

Nuno Sousa , Maria Clara Ferreira Rodrigues , Camila de Souza Madeira , Aline Valéria Gonçalves Gontijo , Luíz Guilherme Malaquias da Silva , Artur Lage Pedroso ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.36557/2674-8169.2025v7n4p309-327

As células-tronco (CT) têm despertado crescente interesse na comunidade científica devido ao seu potencial regenerativo e às amplas possibilidades terapêuticas. A terapia celular baseada em células-tronco representa uma abordagem inovadora para o tratamento de lesões e doenças, oferecendo perspectivas promissoras para a medicina regenerativa. Dentre as diversas fontes de células-tronco, destaca-se a polpa dentária de dentes decíduos esfoliados, um tecido facilmente acessível e obtido de forma minimamente invasiva em crianças. Este estudo tem como objetivo realizar uma revisão integrativa da literatura sobre o potencial das células-tronco mesenquimais derivadas da polpa de dentes decíduos na regeneração óssea, tanto na odontologia quanto em outras áreas da saúde. A pesquisa foi conduzida por meio de levantamentos bibliográficos nas bases de dados Biblioteca Virtual em Saúde (BVS), Google Scholar, PubMed, SciELO e EbscoHost, considerando publicações no período de 2010 a 2025. A seleção dos artigos seguiu critérios de elegibilidade previamente estabelecidos, utilizando descritores em português e inglês, de forma isolada ou combinada, incluindo: "células-tronco", "dentes decíduos", "polpa dentária" e "regeneração óssea”. Os achados da literatura indicam que as células-tronco mesenquimais apresentam baixa imunogenicidade, reduzido risco de rejeição após transplante e capacidade de manutenção em estado indiferenciado por longos períodos quando submetidas à criopreservação. Além disso, as células-tronco derivadas da polpa de dentes decíduos demonstram um potencial significativo para aplicações em engenharia tecidual e terapias regenerativas. Diante disso, é fundamental ampliar o conhecimento entre cirurgiões-dentistas e demais profissionais da saúde sobre essa fonte promissora de células-tronco, suas indicações clínicas, técnicas de obtenção e limitações.

Related Topics

Art

Concepts

Art

Metadata

Type: article
Language: pt
Landing Page: https://doi.org/10.36557/2674-8169.2025v7n4p309-327
PDF: https://bjihs.emnuvens.com.br/bjihs/article/download/5592/5511
OA Status: diamond
Related Works: 10
OpenAlex ID: https://openalex.org/W4409217472

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4409217472

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.36557/2674-8169.2025v7n4p309-327

Digital Object Identifier
Title: Aplicação das Células-Tronco da Polpa Dentária na Regeneração Óssea: Uma Análise da Literatura Científica

Work title
Type: article

OpenAlex work type
Language: pt

Primary language
Publication year: 2025

Year of publication
Publication date: 2025-04-06

Full publication date if available
Authors: Nuno Sousa, Maria Clara Ferreira Rodrigues, Camila de Souza Madeira, Aline Valéria Gonçalves Gontijo, Luíz Guilherme Malaquias da Silva, Artur Lage Pedroso

List of authors in order
Landing page: https://doi.org/10.36557/2674-8169.2025v7n4p309-327

Publisher landing page
PDF URL: https://bjihs.emnuvens.com.br/bjihs/article/download/5592/5511

Direct link to full text PDF
Open access: Yes

Whether a free full text is available
OA status: diamond

Open access status per OpenAlex
OA URL: https://bjihs.emnuvens.com.br/bjihs/article/download/5592/5511

Direct OA link when available
Concepts: Art

Top concepts (fields/topics) attached by OpenAlex
Cited by: 0

Total citation count in OpenAlex
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W4409217472
doi	https://doi.org/10.36557/2674-8169.2025v7n4p309-327
ids.doi	https://doi.org/10.36557/2674-8169.2025v7n4p309-327
ids.openalex	https://openalex.org/W4409217472
fwci	0.0
type	article
title	Aplicação das Células-Tronco da Polpa Dentária na Regeneração Óssea: Uma Análise da Literatura Científica
biblio.issue	4
biblio.volume	7
biblio.last_page	327
biblio.first_page	309
topics[0].id	https://openalex.org/T10729
topics[0].field.id	https://openalex.org/fields/25
topics[0].field.display_name	Materials Science
topics[0].score	0.9178000092506409
topics[0].domain.id	https://openalex.org/domains/3
topics[0].domain.display_name	Physical Sciences
topics[0].subfield.id	https://openalex.org/subfields/2502
topics[0].subfield.display_name	Biomaterials
topics[0].display_name	Electrospun Nanofibers in Biomedical Applications
is_xpac	False
apc_list
apc_paid
concepts[0].id	https://openalex.org/C142362112
concepts[0].level	0
concepts[0].score	0.365378201007843
concepts[0].wikidata	https://www.wikidata.org/wiki/Q735
concepts[0].display_name	Art
keywords[0].id	https://openalex.org/keywords/art
keywords[0].score	0.365378201007843
keywords[0].display_name	Art
language	pt
locations[0].id	doi:10.36557/2674-8169.2025v7n4p309-327
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S4210224230
locations[0].source.issn	2674-8169
locations[0].source.type	journal
locations[0].source.is_oa	True
locations[0].source.issn_l	2674-8169
locations[0].source.is_core	False
locations[0].source.is_in_doaj	False
locations[0].source.display_name	Brazilian Journal of Implantology and Health Sciences
locations[0].source.host_organization
locations[0].source.host_organization_name
locations[0].source.host_organization_lineage
locations[0].license	cc-by
locations[0].pdf_url	https://bjihs.emnuvens.com.br/bjihs/article/download/5592/5511
locations[0].version	publishedVersion
locations[0].raw_type	journal-article
locations[0].license_id	https://openalex.org/licenses/cc-by
locations[0].is_accepted	True
locations[0].is_published	True
locations[0].raw_source_name	Brazilian Journal of Implantology and Health Sciences
locations[0].landing_page_url	https://doi.org/10.36557/2674-8169.2025v7n4p309-327
indexed_in	crossref
authorships[0].author.id	https://openalex.org/A5044111018
authorships[0].author.orcid	https://orcid.org/0000-0002-8755-5126
authorships[0].author.display_name	Nuno Sousa
authorships[0].author_position	first
authorships[0].raw_author_name	Natália Aparecida de Sousa
authorships[0].is_corresponding	False
authorships[1].author.id	https://openalex.org/A5113546676
authorships[1].author.orcid
authorships[1].author.display_name	Maria Clara Ferreira Rodrigues
authorships[1].author_position	middle
authorships[1].raw_author_name	Maria Clara Ferreira Rodrigues
authorships[1].is_corresponding	False
authorships[2].author.id	https://openalex.org/A5117017156
authorships[2].author.orcid
authorships[2].author.display_name	Camila de Souza Madeira
authorships[2].author_position	middle
authorships[2].raw_author_name	Camila de Souza Madeira
authorships[2].is_corresponding	False
authorships[3].author.id	https://openalex.org/A5117017157
authorships[3].author.orcid
authorships[3].author.display_name	Aline Valéria Gonçalves Gontijo
authorships[3].author_position	middle
authorships[3].raw_author_name	Aline Valéria Gonçalves Gontijo
authorships[3].is_corresponding	False
authorships[4].author.id	https://openalex.org/A5058932943
authorships[4].author.orcid	https://orcid.org/0000-0002-2480-8616
authorships[4].author.display_name	Luíz Guilherme Malaquias da Silva
authorships[4].author_position	middle
authorships[4].raw_author_name	Letícia Cristina Silva
authorships[4].is_corresponding	False
authorships[5].author.id	https://openalex.org/A5117017158
authorships[5].author.orcid
authorships[5].author.display_name	Artur Lage Pedroso
authorships[5].author_position	last
authorships[5].raw_author_name	Artur Lage Pedroso
authorships[5].is_corresponding	False
has_content.pdf	True
has_content.grobid_xml	True
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://bjihs.emnuvens.com.br/bjihs/article/download/5592/5511
open_access.oa_status	diamond
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	Aplicação das Células-Tronco da Polpa Dentária na Regeneração Óssea: Uma Análise da Literatura Científica
has_fulltext	False
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T10729
primary_topic.field.id	https://openalex.org/fields/25
primary_topic.field.display_name	Materials Science
primary_topic.score	0.9178000092506409
primary_topic.domain.id	https://openalex.org/domains/3
primary_topic.domain.display_name	Physical Sciences
primary_topic.subfield.id	https://openalex.org/subfields/2502
primary_topic.subfield.display_name	Biomaterials
primary_topic.display_name	Electrospun Nanofibers in Biomedical Applications
related_works	https://openalex.org/W4387497383, https://openalex.org/W3183948672, https://openalex.org/W3173606202, https://openalex.org/W3110381201, https://openalex.org/W2948807893, https://openalex.org/W2899084033, https://openalex.org/W2778153218, https://openalex.org/W2758277628, https://openalex.org/W2748952813, https://openalex.org/W1531601525
cited_by_count	0
locations_count	1
best_oa_location.id	doi:10.36557/2674-8169.2025v7n4p309-327
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S4210224230
best_oa_location.source.issn	2674-8169
best_oa_location.source.type	journal
best_oa_location.source.is_oa	True
best_oa_location.source.issn_l	2674-8169
best_oa_location.source.is_core	False
best_oa_location.source.is_in_doaj	False
best_oa_location.source.display_name	Brazilian Journal of Implantology and Health Sciences
best_oa_location.source.host_organization
best_oa_location.source.host_organization_name
best_oa_location.source.host_organization_lineage
best_oa_location.license	cc-by
best_oa_location.pdf_url	https://bjihs.emnuvens.com.br/bjihs/article/download/5592/5511
best_oa_location.version	publishedVersion
best_oa_location.raw_type	journal-article
best_oa_location.license_id	https://openalex.org/licenses/cc-by
best_oa_location.is_accepted	True
best_oa_location.is_published	True
best_oa_location.raw_source_name	Brazilian Journal of Implantology and Health Sciences
best_oa_location.landing_page_url	https://doi.org/10.36557/2674-8169.2025v7n4p309-327
primary_location.id	doi:10.36557/2674-8169.2025v7n4p309-327
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S4210224230
primary_location.source.issn	2674-8169
primary_location.source.type	journal
primary_location.source.is_oa	True
primary_location.source.issn_l	2674-8169
primary_location.source.is_core	False
primary_location.source.is_in_doaj	False
primary_location.source.display_name	Brazilian Journal of Implantology and Health Sciences
primary_location.source.host_organization
primary_location.source.host_organization_name
primary_location.source.host_organization_lineage
primary_location.license	cc-by
primary_location.pdf_url	https://bjihs.emnuvens.com.br/bjihs/article/download/5592/5511
primary_location.version	publishedVersion
primary_location.raw_type	journal-article
primary_location.license_id	https://openalex.org/licenses/cc-by
primary_location.is_accepted	True
primary_location.is_published	True
primary_location.raw_source_name	Brazilian Journal of Implantology and Health Sciences
primary_location.landing_page_url	https://doi.org/10.36557/2674-8169.2025v7n4p309-327
publication_date	2025-04-06
publication_year	2025
referenced_works_count	0
abstract_inverted_index.A	20, 105, 137
abstract_inverted_index.a	41, 51, 135
abstract_inverted_index.e	15, 35, 62, 127, 151, 164, 185, 218, 230, 247
abstract_inverted_index.o	31, 82, 226
abstract_inverted_index.As	0
abstract_inverted_index.Os	167
abstract_inverted_index.ao	11
abstract_inverted_index.as	45, 173, 201
abstract_inverted_index.da	79, 88, 103, 169, 204, 233
abstract_inverted_index.de	33, 48, 54, 64, 90, 111, 116, 133, 143, 153, 181, 187, 206, 239, 245
abstract_inverted_index.em	24, 68, 100, 120, 149, 189, 215
abstract_inverted_index.na	7, 93, 97
abstract_inverted_index.no	131
abstract_inverted_index.ou	156
abstract_inverted_index.um	58, 210
abstract_inverted_index.à	197
abstract_inverted_index.é	223
abstract_inverted_index.das	84
abstract_inverted_index.dos	139
abstract_inverted_index.foi	107
abstract_inverted_index.nas	114
abstract_inverted_index.por	109, 192
abstract_inverted_index.que	172
abstract_inverted_index.seu	12
abstract_inverted_index.tem	72
abstract_inverted_index.uma	27, 76
abstract_inverted_index.às	16
abstract_inverted_index.(CT)	2
abstract_inverted_index.2010	134
abstract_inverted_index.Este	70
abstract_inverted_index.como	73
abstract_inverted_index.essa	236
abstract_inverted_index.meio	110
abstract_inverted_index.para	30, 40, 213
abstract_inverted_index.suas	241
abstract_inverted_index.têm	3
abstract_inverted_index.2025.	136
abstract_inverted_index.Além	199
abstract_inverted_index.após	183
abstract_inverted_index.baixa	177
abstract_inverted_index.bases	115
abstract_inverted_index.dados	117
abstract_inverted_index.entre	228
abstract_inverted_index.fonte	237
abstract_inverted_index.forma	65, 154
abstract_inverted_index.polpa	52, 89, 205
abstract_inverted_index.risco	180
abstract_inverted_index.sobre	81, 235
abstract_inverted_index.tanto	96
abstract_inverted_index."polpa	162
abstract_inverted_index.(BVS),	122
abstract_inverted_index.Dentre	44
abstract_inverted_index.Diante	221
abstract_inverted_index.Google	123
abstract_inverted_index.Saúde	121
abstract_inverted_index.SciELO	126
abstract_inverted_index.amplas	17
abstract_inverted_index.demais	231
abstract_inverted_index.dentes	55, 91, 207
abstract_inverted_index.devido	10
abstract_inverted_index.disso,	200, 222
abstract_inverted_index.estado	190
abstract_inverted_index.estudo	71
abstract_inverted_index.fontes	47
abstract_inverted_index.longos	193
abstract_inverted_index.obtido	63
abstract_inverted_index.outras	101
abstract_inverted_index.quando	195
abstract_inverted_index.quanto	99
abstract_inverted_index.saúde	234
abstract_inverted_index.seguiu	141
abstract_inverted_index.tecido	59
abstract_inverted_index.áreas	102
abstract_inverted_index."dentes	160
abstract_inverted_index.PubMed,	125
abstract_inverted_index.Virtual	119
abstract_inverted_index.achados	168
abstract_inverted_index.ampliar	225
abstract_inverted_index.artigos	140
abstract_inverted_index.baseada	23
abstract_inverted_index.celular	22
abstract_inverted_index.indicam	171
abstract_inverted_index.isolada	155
abstract_inverted_index.lesões	34
abstract_inverted_index.saúde.	104
abstract_inverted_index.terapia	21
abstract_inverted_index.óssea,	95
abstract_inverted_index.Scholar,	124
abstract_inverted_index.diversas	46
abstract_inverted_index.inglês,	152
abstract_inverted_index.invasiva	67
abstract_inverted_index.medicina	42
abstract_inverted_index.objetivo	74
abstract_inverted_index.período	132
abstract_inverted_index.pesquisa	106
abstract_inverted_index.realizar	75
abstract_inverted_index.reduzido	179
abstract_inverted_index.revisão	77
abstract_inverted_index.tecidual	217
abstract_inverted_index.terapias	219
abstract_inverted_index.abordagem	28
abstract_inverted_index.conduzida	108
abstract_inverted_index.crescente	5
abstract_inverted_index.decíduos	56, 92, 208
abstract_inverted_index.dentária	53
abstract_inverted_index.derivadas	87, 203
abstract_inverted_index.doenças,	36
abstract_inverted_index.inovadora	29
abstract_inverted_index.interesse	6
abstract_inverted_index.períodos	194
abstract_inverted_index.potencial	13, 83, 211
abstract_inverted_index.seleção	138
abstract_inverted_index.técnicas	244
abstract_inverted_index.Biblioteca	118
abstract_inverted_index.EbscoHost,	128
abstract_inverted_index.acessível	61
abstract_inverted_index.apresentam	176
abstract_inverted_index.capacidade	186
abstract_inverted_index.clínicas,	243
abstract_inverted_index.combinada,	157
abstract_inverted_index.comunidade	8
abstract_inverted_index.crianças.	69
abstract_inverted_index.critérios	142
abstract_inverted_index.demonstram	209
abstract_inverted_index.dentária"	163
abstract_inverted_index.despertado	4
abstract_inverted_index.destaca-se	50
abstract_inverted_index.engenharia	216
abstract_inverted_index.facilmente	60
abstract_inverted_index.incluindo:	158
abstract_inverted_index.literatura	80, 170
abstract_inverted_index.obtenção	246
abstract_inverted_index.oferecendo	37
abstract_inverted_index.português	150
abstract_inverted_index.promissora	238
abstract_inverted_index.rejeição	182
abstract_inverted_index.representa	26
abstract_inverted_index.submetidas	196
abstract_inverted_index.tratamento	32
abstract_inverted_index.utilizando	147
abstract_inverted_index.óssea”.	166
abstract_inverted_index.científica	9
abstract_inverted_index.decíduos",	161
abstract_inverted_index.descritores	148
abstract_inverted_index.esfoliados,	57
abstract_inverted_index.fundamental	224
abstract_inverted_index.integrativa	78
abstract_inverted_index.minimamente	66
abstract_inverted_index.odontologia	98
abstract_inverted_index.previamente	145
abstract_inverted_index.promissoras	39
abstract_inverted_index.transplante	184
abstract_inverted_index.aplicações	214
abstract_inverted_index.conhecimento	227
abstract_inverted_index.considerando	129
abstract_inverted_index.indicações	242
abstract_inverted_index.manutenção	188
abstract_inverted_index.mesenquimais	86, 175
abstract_inverted_index.perspectivas	38
abstract_inverted_index.regenerativo	14
abstract_inverted_index.elegibilidade	144
abstract_inverted_index.levantamentos	112
abstract_inverted_index.limitações.	248
abstract_inverted_index.profissionais	232
abstract_inverted_index.publicações	130
abstract_inverted_index.regenerativa.	43
abstract_inverted_index.regeneração	94
abstract_inverted_index.significativo	212
abstract_inverted_index."regeneração	165
abstract_inverted_index.estabelecidos,	146
abstract_inverted_index.indiferenciado	191
abstract_inverted_index.possibilidades	18
abstract_inverted_index.regenerativas.	220
abstract_inverted_index.terapêuticas.	19
abstract_inverted_index.bibliográficos	113
abstract_inverted_index.células-tronco	1, 25, 85, 174, 202
abstract_inverted_index.células-tronco,	49, 240
abstract_inverted_index.imunogenicidade,	178
abstract_inverted_index."células-tronco",	159
abstract_inverted_index.criopreservação.	198
abstract_inverted_index.cirurgiões-dentistas	229
cited_by_percentile_year
countries_distinct_count	0
institutions_distinct_count	6
citation_normalized_percentile.value	0.08633
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False