APOB CRISPR-Cas9 Engineering in Hypobetalipoproteinemia: A Promising Tool for Functional Studies of Novel Variants Article Swipe
Xavier Vanhoye
,
Alexandre Janin
,
Amandine Caillaud
,
Antoine Rimbert
,
Fabienne Venet
,
Morgane Gossez
,
Wieneke Dijk
,
Oriane Marmontel
,
Séverine Nony
,
C. Chatelain
,
Christine Durand
,
Pierre Lindenbaum
,
Jennifer Rieusset
,
Bertrand Cariou
,
Philippe Moulin
,
Mathilde Di Filippo
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/ijms23084281
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/ijms23084281
Hypobetalipoproteinemia is characterized by LDL-cholesterol and apolipoprotein B (apoB) plasma levels below the fifth percentile for age and sex. Familial hypobetalipoproteinemia (FHBL) is mostly caused by premature termination codons in the APOB gene, a condition associated with fatty liver and steatohepatitis. Nevertheless, many families with a FHBL phenotype carry APOB missense variants of uncertain significance (VUS). We here aimed to develop a proof-of-principle experiment to assess the pathogenicity of VUS using the genome editing of human liver cells. We identified a novel heterozygous APOB-VUS (p.Leu351Arg), in a FHBL family. We generated APOB knock-out (KO) and APOB-p.Leu351Arg knock-in Huh7 cells using CRISPR-Cas9 technology and studied the APOB expression, synthesis and secretion by digital droplet PCR and ELISA quantification. The APOB expression was decreased by 70% in the heterozygous APOB-KO cells and almost abolished in the homozygous-KO cells, with a consistent decrease in apoB production and secretion. The APOB-p.Leu351Arg homozygous cells presented with a 40% decreased APOB expression and undetectable apoB levels in cellular extracts and supernatant. Thus, the p.Leu351Arg affected the apoB secretion, which led us to classify this new variant as likely pathogenic and to set up a hepatic follow-up in this family. Therefore, the functional assessment of APOB-missense variants, using gene-editing technologies, will lead to improvements in the molecular diagnosis of FHBL and the personalized follow-up of these patients.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms23084281
- https://www.mdpi.com/1422-0067/23/8/4281/pdf?version=1649829661
- OA Status
- gold
- Cited By
- 10
- References
- 58
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4224102582
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4224102582Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ijms23084281Digital Object Identifier
- Title
-
APOB CRISPR-Cas9 Engineering in Hypobetalipoproteinemia: A Promising Tool for Functional Studies of Novel VariantsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-04-13Full publication date if available
- Authors
-
Xavier Vanhoye, Alexandre Janin, Amandine Caillaud, Antoine Rimbert, Fabienne Venet, Morgane Gossez, Wieneke Dijk, Oriane Marmontel, Séverine Nony, C. Chatelain, Christine Durand, Pierre Lindenbaum, Jennifer Rieusset, Bertrand Cariou, Philippe Moulin, Mathilde Di FilippoList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms23084281Publisher landing page
- PDF URL
-
https://www.mdpi.com/1422-0067/23/8/4281/pdf?version=1649829661Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1422-0067/23/8/4281/pdf?version=1649829661Direct OA link when available
- Concepts
-
CRISPR, Computational biology, Apolipoprotein B, Biology, Genetics, Gene, Biochemistry, CholesterolTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
10Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 1, 2023: 6, 2022: 1Per-year citation counts (last 5 years)
- References (count)
-
58Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4224102582 |
|---|---|
| doi | https://doi.org/10.3390/ijms23084281 |
| ids.doi | https://doi.org/10.3390/ijms23084281 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/35457099 |
| ids.openalex | https://openalex.org/W4224102582 |
| fwci | 1.23069158 |
| mesh[0].qualifier_ui | Q000378 |
| mesh[0].descriptor_ui | D001055 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | metabolism |
| mesh[0].descriptor_name | Apolipoproteins B |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D064113 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | CRISPR-Cas Systems |
| mesh[2].qualifier_ui | Q000235 |
| mesh[2].descriptor_ui | D005234 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | genetics |
| mesh[2].descriptor_name | Fatty Liver |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D006801 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Humans |
| mesh[4].qualifier_ui | Q000235 |
| mesh[4].descriptor_ui | D052476 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | genetics |
| mesh[4].descriptor_name | Hypobetalipoproteinemia, Familial, Apolipoprotein B |
| mesh[5].qualifier_ui | Q000175 |
| mesh[5].descriptor_ui | D006995 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | diagnosis |
| mesh[5].descriptor_name | Hypobetalipoproteinemias |
| mesh[6].qualifier_ui | Q000235 |
| mesh[6].descriptor_ui | D006995 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | genetics |
| mesh[6].descriptor_name | Hypobetalipoproteinemias |
| mesh[7].qualifier_ui | Q000378 |
| mesh[7].descriptor_ui | D006995 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | metabolism |
| mesh[7].descriptor_name | Hypobetalipoproteinemias |
| mesh[8].qualifier_ui | Q000378 |
| mesh[8].descriptor_ui | D001055 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | metabolism |
| mesh[8].descriptor_name | Apolipoproteins B |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D064113 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | CRISPR-Cas Systems |
| mesh[10].qualifier_ui | Q000235 |
| mesh[10].descriptor_ui | D005234 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | genetics |
| mesh[10].descriptor_name | Fatty Liver |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D006801 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Humans |
| mesh[12].qualifier_ui | Q000235 |
| mesh[12].descriptor_ui | D052476 |
| mesh[12].is_major_topic | True |
| mesh[12].qualifier_name | genetics |
| mesh[12].descriptor_name | Hypobetalipoproteinemia, Familial, Apolipoprotein B |
| mesh[13].qualifier_ui | Q000175 |
| mesh[13].descriptor_ui | D006995 |
| mesh[13].is_major_topic | True |
| mesh[13].qualifier_name | diagnosis |
| mesh[13].descriptor_name | Hypobetalipoproteinemias |
| mesh[14].qualifier_ui | Q000235 |
| mesh[14].descriptor_ui | D006995 |
| mesh[14].is_major_topic | True |
| mesh[14].qualifier_name | genetics |
| mesh[14].descriptor_name | Hypobetalipoproteinemias |
| mesh[15].qualifier_ui | Q000378 |
| mesh[15].descriptor_ui | D006995 |
| mesh[15].is_major_topic | True |
| mesh[15].qualifier_name | metabolism |
| mesh[15].descriptor_name | Hypobetalipoproteinemias |
| mesh[16].qualifier_ui | Q000378 |
| mesh[16].descriptor_ui | D001055 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | metabolism |
| mesh[16].descriptor_name | Apolipoproteins B |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D064113 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | CRISPR-Cas Systems |
| mesh[18].qualifier_ui | Q000235 |
| mesh[18].descriptor_ui | D005234 |
| mesh[18].is_major_topic | True |
| mesh[18].qualifier_name | genetics |
| mesh[18].descriptor_name | Fatty Liver |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D006801 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Humans |
| mesh[20].qualifier_ui | Q000235 |
| mesh[20].descriptor_ui | D052476 |
| mesh[20].is_major_topic | True |
| mesh[20].qualifier_name | genetics |
| mesh[20].descriptor_name | Hypobetalipoproteinemia, Familial, Apolipoprotein B |
| mesh[21].qualifier_ui | Q000175 |
| mesh[21].descriptor_ui | D006995 |
| mesh[21].is_major_topic | True |
| mesh[21].qualifier_name | diagnosis |
| mesh[21].descriptor_name | Hypobetalipoproteinemias |
| mesh[22].qualifier_ui | Q000235 |
| mesh[22].descriptor_ui | D006995 |
| mesh[22].is_major_topic | True |
| mesh[22].qualifier_name | genetics |
| mesh[22].descriptor_name | Hypobetalipoproteinemias |
| mesh[23].qualifier_ui | Q000378 |
| mesh[23].descriptor_ui | D006995 |
| mesh[23].is_major_topic | True |
| mesh[23].qualifier_name | metabolism |
| mesh[23].descriptor_name | Hypobetalipoproteinemias |
| type | article |
| title | APOB CRISPR-Cas9 Engineering in Hypobetalipoproteinemia: A Promising Tool for Functional Studies of Novel Variants |
| awards[0].id | https://openalex.org/G5874667850 |
| awards[0].funder_id | https://openalex.org/F4320323878 |
| awards[0].display_name | |
| awards[0].funder_award_id | Young Researcher Project |
| awards[0].funder_display_name | Hospices Civils de Lyon |
| awards[1].id | https://openalex.org/G8181134070 |
| awards[1].funder_id | https://openalex.org/F4320320883 |
| awards[1].display_name | |
| awards[1].funder_award_id | ANR-16-RHUS-0007 |
| awards[1].funder_display_name | Agence Nationale de la Recherche |
| biblio.issue | 8 |
| biblio.volume | 23 |
| biblio.last_page | 4281 |
| biblio.first_page | 4281 |
| topics[0].id | https://openalex.org/T10878 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9976999759674072 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | CRISPR and Genetic Engineering |
| topics[1].id | https://openalex.org/T10949 |
| topics[1].field.id | https://openalex.org/fields/28 |
| topics[1].field.display_name | Neuroscience |
| topics[1].score | 0.9828000068664551 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2804 |
| topics[1].subfield.display_name | Cellular and Molecular Neuroscience |
| topics[1].display_name | Genetic Neurodegenerative Diseases |
| topics[2].id | https://openalex.org/T10587 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9782000184059143 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2713 |
| topics[2].subfield.display_name | Epidemiology |
| topics[2].display_name | Autophagy in Disease and Therapy |
| funders[0].id | https://openalex.org/F4320320883 |
| funders[0].ror | https://ror.org/00rbzpz17 |
| funders[0].display_name | Agence Nationale de la Recherche |
| funders[1].id | https://openalex.org/F4320323878 |
| funders[1].ror | https://ror.org/01502ca60 |
| funders[1].display_name | Hospices Civils de Lyon |
| is_xpac | False |
| apc_list.value | 2300 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2490 |
| apc_paid.value | 2073 |
| apc_paid.currency | EUR |
| apc_paid.value_usd | 2235 |
| concepts[0].id | https://openalex.org/C98108389 |
| concepts[0].level | 3 |
| concepts[0].score | 0.9277582764625549 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q412563 |
| concepts[0].display_name | CRISPR |
| concepts[1].id | https://openalex.org/C70721500 |
| concepts[1].level | 1 |
| concepts[1].score | 0.5812113881111145 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q177005 |
| concepts[1].display_name | Computational biology |
| concepts[2].id | https://openalex.org/C62746215 |
| concepts[2].level | 3 |
| concepts[2].score | 0.415926456451416 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q14890615 |
| concepts[2].display_name | Apolipoprotein B |
| concepts[3].id | https://openalex.org/C86803240 |
| concepts[3].level | 0 |
| concepts[3].score | 0.38643237948417664 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[3].display_name | Biology |
| concepts[4].id | https://openalex.org/C54355233 |
| concepts[4].level | 1 |
| concepts[4].score | 0.286309152841568 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[4].display_name | Genetics |
| concepts[5].id | https://openalex.org/C104317684 |
| concepts[5].level | 2 |
| concepts[5].score | 0.17451617121696472 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[5].display_name | Gene |
| concepts[6].id | https://openalex.org/C55493867 |
| concepts[6].level | 1 |
| concepts[6].score | 0.0654129683971405 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[6].display_name | Biochemistry |
| concepts[7].id | https://openalex.org/C2778163477 |
| concepts[7].level | 2 |
| concepts[7].score | 0.050521016120910645 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q43656 |
| concepts[7].display_name | Cholesterol |
| keywords[0].id | https://openalex.org/keywords/crispr |
| keywords[0].score | 0.9277582764625549 |
| keywords[0].display_name | CRISPR |
| keywords[1].id | https://openalex.org/keywords/computational-biology |
| keywords[1].score | 0.5812113881111145 |
| keywords[1].display_name | Computational biology |
| keywords[2].id | https://openalex.org/keywords/apolipoprotein-b |
| keywords[2].score | 0.415926456451416 |
| keywords[2].display_name | Apolipoprotein B |
| keywords[3].id | https://openalex.org/keywords/biology |
| keywords[3].score | 0.38643237948417664 |
| keywords[3].display_name | Biology |
| keywords[4].id | https://openalex.org/keywords/genetics |
| keywords[4].score | 0.286309152841568 |
| keywords[4].display_name | Genetics |
| keywords[5].id | https://openalex.org/keywords/gene |
| keywords[5].score | 0.17451617121696472 |
| keywords[5].display_name | Gene |
| keywords[6].id | https://openalex.org/keywords/biochemistry |
| keywords[6].score | 0.0654129683971405 |
| keywords[6].display_name | Biochemistry |
| keywords[7].id | https://openalex.org/keywords/cholesterol |
| keywords[7].score | 0.050521016120910645 |
| keywords[7].display_name | Cholesterol |
| language | en |
| locations[0].id | doi:10.3390/ijms23084281 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S10623703 |
| locations[0].source.issn | 1422-0067, 1661-6596 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1422-0067 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | International Journal of Molecular Sciences |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/1422-0067/23/8/4281/pdf?version=1649829661 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | International Journal of Molecular Sciences |
| locations[0].landing_page_url | https://doi.org/10.3390/ijms23084281 |
| locations[1].id | pmid:35457099 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | International journal of molecular sciences |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/35457099 |
| locations[2].id | pmh:oai:HAL:hal-03659209v1 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306402512 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | HAL (Le Centre pour la Communication Scientifique Directe) |
| locations[2].source.host_organization | https://openalex.org/I1294671590 |
| locations[2].source.host_organization_name | Centre National de la Recherche Scientifique |
| locations[2].source.host_organization_lineage | https://openalex.org/I1294671590 |
| locations[2].license | cc-by |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Journal articles |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | International Journal of Molecular Sciences, 2022, 23 (8), pp.4281. ⟨10.3390/ijms23084281⟩ |
| locations[2].landing_page_url | https://hal.inrae.fr/hal-03659209 |
| locations[3].id | pmh:oai:doaj.org/article:e2ca63f47c0e4450bc327462cfb59715 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306401280 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[3].source.host_organization | |
| locations[3].source.host_organization_name | |
| locations[3].license | cc-by-sa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | International Journal of Molecular Sciences, Vol 23, Iss 4281, p 4281 (2022) |
| locations[3].landing_page_url | https://doaj.org/article/e2ca63f47c0e4450bc327462cfb59715 |
| locations[4].id | pmh:oai:mdpi.com:/1422-0067/23/8/4281/ |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S4306400947 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | True |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | MDPI (MDPI AG) |
| locations[4].source.host_organization | https://openalex.org/I4210097602 |
| locations[4].source.host_organization_name | Multidisciplinary Digital Publishing Institute (Switzerland) |
| locations[4].source.host_organization_lineage | https://openalex.org/I4210097602 |
| locations[4].license | cc-by |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | Text |
| locations[4].license_id | https://openalex.org/licenses/cc-by |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | International Journal of Molecular Sciences; Volume 23; Issue 8; Pages: 4281 |
| locations[4].landing_page_url | https://dx.doi.org/10.3390/ijms23084281 |
| locations[5].id | pmh:oai:pubmedcentral.nih.gov:9030618 |
| locations[5].is_oa | True |
| locations[5].source.id | https://openalex.org/S2764455111 |
| locations[5].source.issn | |
| locations[5].source.type | repository |
| locations[5].source.is_oa | False |
| locations[5].source.issn_l | |
| locations[5].source.is_core | False |
| locations[5].source.is_in_doaj | False |
| locations[5].source.display_name | PubMed Central |
| locations[5].source.host_organization | https://openalex.org/I1299303238 |
| locations[5].source.host_organization_name | National Institutes of Health |
| locations[5].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[5].license | other-oa |
| locations[5].pdf_url | |
| locations[5].version | submittedVersion |
| locations[5].raw_type | Text |
| locations[5].license_id | https://openalex.org/licenses/other-oa |
| locations[5].is_accepted | False |
| locations[5].is_published | False |
| locations[5].raw_source_name | Int J Mol Sci |
| locations[5].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/9030618 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5009211715 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-8875-5851 |
| authorships[0].author.display_name | Xavier Vanhoye |
| authorships[0].countries | FR |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210100596 |
| authorships[0].affiliations[0].raw_affiliation_string | Service de Biochimie et de Biologie Moléculaire, Laboratoire de Biologie Médicale MultiSites, Hospices Civils de Lyon, F-69677 Bron, France |
| authorships[0].institutions[0].id | https://openalex.org/I4210100596 |
| authorships[0].institutions[0].ror | https://ror.org/01502ca60 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210100596 |
| authorships[0].institutions[0].country_code | FR |
| authorships[0].institutions[0].display_name | Hospices Civils de Lyon |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Xavier Vanhoye |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Service de Biochimie et de Biologie Moléculaire, Laboratoire de Biologie Médicale MultiSites, Hospices Civils de Lyon, F-69677 Bron, France |
| authorships[1].author.id | https://openalex.org/A5064064148 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-3571-003X |
| authorships[1].author.display_name | Alexandre Janin |
| authorships[1].countries | FR |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I100532134, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I4210125101 |
| authorships[1].affiliations[0].raw_affiliation_string | Institut NeuroMyoGène, CNRS UMR5310, INSERM U1217, Université Claude Bernard Lyon 1, Université de Lyon, F-69008 Lyon, France |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I4210100596 |
| authorships[1].affiliations[1].raw_affiliation_string | Service de Biochimie et de Biologie Moléculaire, Laboratoire de Biologie Médicale MultiSites, Hospices Civils de Lyon, F-69677 Bron, France |
| authorships[1].institutions[0].id | https://openalex.org/I1294671590 |
| authorships[1].institutions[0].ror | https://ror.org/02feahw73 |
| authorships[1].institutions[0].type | government |
| authorships[1].institutions[0].lineage | https://openalex.org/I1294671590 |
| authorships[1].institutions[0].country_code | FR |
| authorships[1].institutions[0].display_name | Centre National de la Recherche Scientifique |
| authorships[1].institutions[1].id | https://openalex.org/I4210100596 |
| authorships[1].institutions[1].ror | https://ror.org/01502ca60 |
| authorships[1].institutions[1].type | healthcare |
| authorships[1].institutions[1].lineage | https://openalex.org/I4210100596 |
| authorships[1].institutions[1].country_code | FR |
| authorships[1].institutions[1].display_name | Hospices Civils de Lyon |
| authorships[1].institutions[2].id | https://openalex.org/I154526488 |
| authorships[1].institutions[2].ror | https://ror.org/02vjkv261 |
| authorships[1].institutions[2].type | government |
| authorships[1].institutions[2].lineage | https://openalex.org/I154526488 |
| authorships[1].institutions[2].country_code | FR |
| authorships[1].institutions[2].display_name | Inserm |
| authorships[1].institutions[3].id | https://openalex.org/I4210125101 |
| authorships[1].institutions[3].ror | https://ror.org/0322sf130 |
| authorships[1].institutions[3].type | facility |
| authorships[1].institutions[3].lineage | https://openalex.org/I100532134, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I203339264, https://openalex.org/I4210096427, https://openalex.org/I4210125101 |
| authorships[1].institutions[3].country_code | FR |
| authorships[1].institutions[3].display_name | Institut NeuroMyoGène |
| authorships[1].institutions[4].id | https://openalex.org/I100532134 |
| authorships[1].institutions[4].ror | https://ror.org/029brtt94 |
| authorships[1].institutions[4].type | education |
| authorships[1].institutions[4].lineage | https://openalex.org/I100532134, https://openalex.org/I203339264 |
| authorships[1].institutions[4].country_code | FR |
| authorships[1].institutions[4].display_name | Université Claude Bernard Lyon 1 |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Alexandre Janin |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Institut NeuroMyoGène, CNRS UMR5310, INSERM U1217, Université Claude Bernard Lyon 1, Université de Lyon, F-69008 Lyon, France, Service de Biochimie et de Biologie Moléculaire, Laboratoire de Biologie Médicale MultiSites, Hospices Civils de Lyon, F-69677 Bron, France |
| authorships[2].author.id | https://openalex.org/A5025483584 |
| authorships[2].author.orcid | https://orcid.org/0000-0001-6409-2336 |
| authorships[2].author.display_name | Amandine Caillaud |
| authorships[2].countries | FR |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I4210144168, https://openalex.org/I97188460 |
| authorships[2].affiliations[0].raw_affiliation_string | Institut du Thorax, Nantes Université, CHU Nantes, CNRS, INSERM, F-44000 Nantes, France |
| authorships[2].institutions[0].id | https://openalex.org/I1294671590 |
| authorships[2].institutions[0].ror | https://ror.org/02feahw73 |
| authorships[2].institutions[0].type | government |
| authorships[2].institutions[0].lineage | https://openalex.org/I1294671590 |
| authorships[2].institutions[0].country_code | FR |
| authorships[2].institutions[0].display_name | Centre National de la Recherche Scientifique |
| authorships[2].institutions[1].id | https://openalex.org/I154526488 |
| authorships[2].institutions[1].ror | https://ror.org/02vjkv261 |
| authorships[2].institutions[1].type | government |
| authorships[2].institutions[1].lineage | https://openalex.org/I154526488 |
| authorships[2].institutions[1].country_code | FR |
| authorships[2].institutions[1].display_name | Inserm |
| authorships[2].institutions[2].id | https://openalex.org/I4210144168 |
| authorships[2].institutions[2].ror | https://ror.org/049kkt456 |
| authorships[2].institutions[2].type | facility |
| authorships[2].institutions[2].lineage | https://openalex.org/I1294671590, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I4210096427, https://openalex.org/I4210144168, https://openalex.org/I97188460 |
| authorships[2].institutions[2].country_code | FR |
| authorships[2].institutions[2].display_name | Institut du Thorax |
| authorships[2].institutions[3].id | https://openalex.org/I97188460 |
| authorships[2].institutions[3].ror | https://ror.org/03gnr7b55 |
| authorships[2].institutions[3].type | education |
| authorships[2].institutions[3].lineage | https://openalex.org/I97188460 |
| authorships[2].institutions[3].country_code | FR |
| authorships[2].institutions[3].display_name | Nantes Université |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Amandine Caillaud |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Institut du Thorax, Nantes Université, CHU Nantes, CNRS, INSERM, F-44000 Nantes, France |
| authorships[3].author.id | https://openalex.org/A5063913582 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-2971-4926 |
| authorships[3].author.display_name | Antoine Rimbert |
| authorships[3].countries | FR |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I4210144168, https://openalex.org/I97188460 |
| authorships[3].affiliations[0].raw_affiliation_string | Institut du Thorax, Nantes Université, CNRS, INSERM, F-44000 Nantes, France |
| authorships[3].institutions[0].id | https://openalex.org/I1294671590 |
| authorships[3].institutions[0].ror | https://ror.org/02feahw73 |
| authorships[3].institutions[0].type | government |
| authorships[3].institutions[0].lineage | https://openalex.org/I1294671590 |
| authorships[3].institutions[0].country_code | FR |
| authorships[3].institutions[0].display_name | Centre National de la Recherche Scientifique |
| authorships[3].institutions[1].id | https://openalex.org/I154526488 |
| authorships[3].institutions[1].ror | https://ror.org/02vjkv261 |
| authorships[3].institutions[1].type | government |
| authorships[3].institutions[1].lineage | https://openalex.org/I154526488 |
| authorships[3].institutions[1].country_code | FR |
| authorships[3].institutions[1].display_name | Inserm |
| authorships[3].institutions[2].id | https://openalex.org/I4210144168 |
| authorships[3].institutions[2].ror | https://ror.org/049kkt456 |
| authorships[3].institutions[2].type | facility |
| authorships[3].institutions[2].lineage | https://openalex.org/I1294671590, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I4210096427, https://openalex.org/I4210144168, https://openalex.org/I97188460 |
| authorships[3].institutions[2].country_code | FR |
| authorships[3].institutions[2].display_name | Institut du Thorax |
| authorships[3].institutions[3].id | https://openalex.org/I97188460 |
| authorships[3].institutions[3].ror | https://ror.org/03gnr7b55 |
| authorships[3].institutions[3].type | education |
| authorships[3].institutions[3].lineage | https://openalex.org/I97188460 |
| authorships[3].institutions[3].country_code | FR |
| authorships[3].institutions[3].display_name | Nantes Université |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Antoine Rimbert |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Institut du Thorax, Nantes Université, CNRS, INSERM, F-44000 Nantes, France |
| authorships[4].author.id | https://openalex.org/A5082678142 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-0462-4235 |
| authorships[4].author.display_name | Fabienne Venet |
| authorships[4].countries | FR |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210100596 |
| authorships[4].affiliations[0].raw_affiliation_string | Laboratoire d'Immunologie, Edouard Herriot Hospital, Hospices Civils de Lyon, F-69437 Lyon, France |
| authorships[4].affiliations[1].institution_ids | https://openalex.org/I100532134, https://openalex.org/I113428412, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I4210161906 |
| authorships[4].affiliations[1].raw_affiliation_string | Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Claude Bernard-Lyon 1, F-69364 Lyon, France |
| authorships[4].institutions[0].id | https://openalex.org/I4210161906 |
| authorships[4].institutions[0].ror | https://ror.org/059sz6q14 |
| authorships[4].institutions[0].type | facility |
| authorships[4].institutions[0].lineage | https://openalex.org/I100532134, https://openalex.org/I113428412, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I203339264, https://openalex.org/I4210100596, https://openalex.org/I4210161906, https://openalex.org/I4412460541 |
| authorships[4].institutions[0].country_code | FR |
| authorships[4].institutions[0].display_name | Centre International de Recherche en Infectiologie |
| authorships[4].institutions[1].id | https://openalex.org/I1294671590 |
| authorships[4].institutions[1].ror | https://ror.org/02feahw73 |
| authorships[4].institutions[1].type | government |
| authorships[4].institutions[1].lineage | https://openalex.org/I1294671590 |
| authorships[4].institutions[1].country_code | FR |
| authorships[4].institutions[1].display_name | Centre National de la Recherche Scientifique |
| authorships[4].institutions[2].id | https://openalex.org/I4210100596 |
| authorships[4].institutions[2].ror | https://ror.org/01502ca60 |
| authorships[4].institutions[2].type | healthcare |
| authorships[4].institutions[2].lineage | https://openalex.org/I4210100596 |
| authorships[4].institutions[2].country_code | FR |
| authorships[4].institutions[2].display_name | Hospices Civils de Lyon |
| authorships[4].institutions[3].id | https://openalex.org/I154526488 |
| authorships[4].institutions[3].ror | https://ror.org/02vjkv261 |
| authorships[4].institutions[3].type | government |
| authorships[4].institutions[3].lineage | https://openalex.org/I154526488 |
| authorships[4].institutions[3].country_code | FR |
| authorships[4].institutions[3].display_name | Inserm |
| authorships[4].institutions[4].id | https://openalex.org/I100532134 |
| authorships[4].institutions[4].ror | https://ror.org/029brtt94 |
| authorships[4].institutions[4].type | education |
| authorships[4].institutions[4].lineage | https://openalex.org/I100532134, https://openalex.org/I203339264 |
| authorships[4].institutions[4].country_code | FR |
| authorships[4].institutions[4].display_name | Université Claude Bernard Lyon 1 |
| authorships[4].institutions[5].id | https://openalex.org/I113428412 |
| authorships[4].institutions[5].ror | https://ror.org/04zmssz18 |
| authorships[4].institutions[5].type | education |
| authorships[4].institutions[5].lineage | https://openalex.org/I113428412, https://openalex.org/I203339264 |
| authorships[4].institutions[5].country_code | FR |
| authorships[4].institutions[5].display_name | École Normale Supérieure de Lyon |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Fabienne Venet |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Claude Bernard-Lyon 1, F-69364 Lyon, France, Laboratoire d'Immunologie, Edouard Herriot Hospital, Hospices Civils de Lyon, F-69437 Lyon, France |
| authorships[5].author.id | https://openalex.org/A5014475255 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-1930-8956 |
| authorships[5].author.display_name | Morgane Gossez |
| authorships[5].countries | FR |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210100596 |
| authorships[5].affiliations[0].raw_affiliation_string | Laboratoire d'Immunologie, Edouard Herriot Hospital, Hospices Civils de Lyon, F-69437 Lyon, France |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I100532134, https://openalex.org/I113428412, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I4210161906 |
| authorships[5].affiliations[1].raw_affiliation_string | Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Claude Bernard-Lyon 1, F-69364 Lyon, France |
| authorships[5].institutions[0].id | https://openalex.org/I4210161906 |
| authorships[5].institutions[0].ror | https://ror.org/059sz6q14 |
| authorships[5].institutions[0].type | facility |
| authorships[5].institutions[0].lineage | https://openalex.org/I100532134, https://openalex.org/I113428412, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I203339264, https://openalex.org/I4210100596, https://openalex.org/I4210161906, https://openalex.org/I4412460541 |
| authorships[5].institutions[0].country_code | FR |
| authorships[5].institutions[0].display_name | Centre International de Recherche en Infectiologie |
| authorships[5].institutions[1].id | https://openalex.org/I1294671590 |
| authorships[5].institutions[1].ror | https://ror.org/02feahw73 |
| authorships[5].institutions[1].type | government |
| authorships[5].institutions[1].lineage | https://openalex.org/I1294671590 |
| authorships[5].institutions[1].country_code | FR |
| authorships[5].institutions[1].display_name | Centre National de la Recherche Scientifique |
| authorships[5].institutions[2].id | https://openalex.org/I4210100596 |
| authorships[5].institutions[2].ror | https://ror.org/01502ca60 |
| authorships[5].institutions[2].type | healthcare |
| authorships[5].institutions[2].lineage | https://openalex.org/I4210100596 |
| authorships[5].institutions[2].country_code | FR |
| authorships[5].institutions[2].display_name | Hospices Civils de Lyon |
| authorships[5].institutions[3].id | https://openalex.org/I154526488 |
| authorships[5].institutions[3].ror | https://ror.org/02vjkv261 |
| authorships[5].institutions[3].type | government |
| authorships[5].institutions[3].lineage | https://openalex.org/I154526488 |
| authorships[5].institutions[3].country_code | FR |
| authorships[5].institutions[3].display_name | Inserm |
| authorships[5].institutions[4].id | https://openalex.org/I100532134 |
| authorships[5].institutions[4].ror | https://ror.org/029brtt94 |
| authorships[5].institutions[4].type | education |
| authorships[5].institutions[4].lineage | https://openalex.org/I100532134, https://openalex.org/I203339264 |
| authorships[5].institutions[4].country_code | FR |
| authorships[5].institutions[4].display_name | Université Claude Bernard Lyon 1 |
| authorships[5].institutions[5].id | https://openalex.org/I113428412 |
| authorships[5].institutions[5].ror | https://ror.org/04zmssz18 |
| authorships[5].institutions[5].type | education |
| authorships[5].institutions[5].lineage | https://openalex.org/I113428412, https://openalex.org/I203339264 |
| authorships[5].institutions[5].country_code | FR |
| authorships[5].institutions[5].display_name | École Normale Supérieure de Lyon |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Morgane Gossez |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Claude Bernard-Lyon 1, F-69364 Lyon, France, Laboratoire d'Immunologie, Edouard Herriot Hospital, Hospices Civils de Lyon, F-69437 Lyon, France |
| authorships[6].author.id | https://openalex.org/A5063605678 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-1676-7751 |
| authorships[6].author.display_name | Wieneke Dijk |
| authorships[6].countries | FR |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I4210144168, https://openalex.org/I97188460 |
| authorships[6].affiliations[0].raw_affiliation_string | Institut du Thorax, Nantes Université, CNRS, INSERM, F-44000 Nantes, France |
| authorships[6].institutions[0].id | https://openalex.org/I1294671590 |
| authorships[6].institutions[0].ror | https://ror.org/02feahw73 |
| authorships[6].institutions[0].type | government |
| authorships[6].institutions[0].lineage | https://openalex.org/I1294671590 |
| authorships[6].institutions[0].country_code | FR |
| authorships[6].institutions[0].display_name | Centre National de la Recherche Scientifique |
| authorships[6].institutions[1].id | https://openalex.org/I154526488 |
| authorships[6].institutions[1].ror | https://ror.org/02vjkv261 |
| authorships[6].institutions[1].type | government |
| authorships[6].institutions[1].lineage | https://openalex.org/I154526488 |
| authorships[6].institutions[1].country_code | FR |
| authorships[6].institutions[1].display_name | Inserm |
| authorships[6].institutions[2].id | https://openalex.org/I4210144168 |
| authorships[6].institutions[2].ror | https://ror.org/049kkt456 |
| authorships[6].institutions[2].type | facility |
| authorships[6].institutions[2].lineage | https://openalex.org/I1294671590, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I4210096427, https://openalex.org/I4210144168, https://openalex.org/I97188460 |
| authorships[6].institutions[2].country_code | FR |
| authorships[6].institutions[2].display_name | Institut du Thorax |
| authorships[6].institutions[3].id | https://openalex.org/I97188460 |
| authorships[6].institutions[3].ror | https://ror.org/03gnr7b55 |
| authorships[6].institutions[3].type | education |
| authorships[6].institutions[3].lineage | https://openalex.org/I97188460 |
| authorships[6].institutions[3].country_code | FR |
| authorships[6].institutions[3].display_name | Nantes Université |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Wieneke Dijk |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Institut du Thorax, Nantes Université, CNRS, INSERM, F-44000 Nantes, France |
| authorships[7].author.id | https://openalex.org/A5025931656 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-4916-6613 |
| authorships[7].author.display_name | Oriane Marmontel |
| authorships[7].countries | FR |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210100596 |
| authorships[7].affiliations[0].raw_affiliation_string | Service de Biochimie et de Biologie Moléculaire, Laboratoire de Biologie Médicale MultiSites, Hospices Civils de Lyon, F-69677 Bron, France |
| authorships[7].affiliations[1].institution_ids | https://openalex.org/I100532134, https://openalex.org/I154526488, https://openalex.org/I48430043 |
| authorships[7].affiliations[1].raw_affiliation_string | CarMen Laboratory, INSERM, INRA, INSA Lyon, Université Claude Bernard Lyon 1, Pierre-Bénite, F-69364 Lyon, France |
| authorships[7].institutions[0].id | https://openalex.org/I4210100596 |
| authorships[7].institutions[0].ror | https://ror.org/01502ca60 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I4210100596 |
| authorships[7].institutions[0].country_code | FR |
| authorships[7].institutions[0].display_name | Hospices Civils de Lyon |
| authorships[7].institutions[1].id | https://openalex.org/I154526488 |
| authorships[7].institutions[1].ror | https://ror.org/02vjkv261 |
| authorships[7].institutions[1].type | government |
| authorships[7].institutions[1].lineage | https://openalex.org/I154526488 |
| authorships[7].institutions[1].country_code | FR |
| authorships[7].institutions[1].display_name | Inserm |
| authorships[7].institutions[2].id | https://openalex.org/I48430043 |
| authorships[7].institutions[2].ror | https://ror.org/050jn9y42 |
| authorships[7].institutions[2].type | education |
| authorships[7].institutions[2].lineage | https://openalex.org/I203339264, https://openalex.org/I48430043 |
| authorships[7].institutions[2].country_code | FR |
| authorships[7].institutions[2].display_name | Institut National des Sciences Appliquées de Lyon |
| authorships[7].institutions[3].id | https://openalex.org/I100532134 |
| authorships[7].institutions[3].ror | https://ror.org/029brtt94 |
| authorships[7].institutions[3].type | education |
| authorships[7].institutions[3].lineage | https://openalex.org/I100532134, https://openalex.org/I203339264 |
| authorships[7].institutions[3].country_code | FR |
| authorships[7].institutions[3].display_name | Université Claude Bernard Lyon 1 |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Oriane Marmontel |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | CarMen Laboratory, INSERM, INRA, INSA Lyon, Université Claude Bernard Lyon 1, Pierre-Bénite, F-69364 Lyon, France, Service de Biochimie et de Biologie Moléculaire, Laboratoire de Biologie Médicale MultiSites, Hospices Civils de Lyon, F-69677 Bron, France |
| authorships[8].author.id | https://openalex.org/A5112749894 |
| authorships[8].author.orcid | |
| authorships[8].author.display_name | Séverine Nony |
| authorships[8].countries | FR |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I4210100596 |
| authorships[8].affiliations[0].raw_affiliation_string | Service de Biochimie et de Biologie Moléculaire, Laboratoire de Biologie Médicale MultiSites, Hospices Civils de Lyon, F-69677 Bron, France |
| authorships[8].institutions[0].id | https://openalex.org/I4210100596 |
| authorships[8].institutions[0].ror | https://ror.org/01502ca60 |
| authorships[8].institutions[0].type | healthcare |
| authorships[8].institutions[0].lineage | https://openalex.org/I4210100596 |
| authorships[8].institutions[0].country_code | FR |
| authorships[8].institutions[0].display_name | Hospices Civils de Lyon |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Séverine Nony |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Service de Biochimie et de Biologie Moléculaire, Laboratoire de Biologie Médicale MultiSites, Hospices Civils de Lyon, F-69677 Bron, France |
| authorships[9].author.id | https://openalex.org/A5048172417 |
| authorships[9].author.orcid | |
| authorships[9].author.display_name | C. Chatelain |
| authorships[9].countries | FR |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I4210100596 |
| authorships[9].affiliations[0].raw_affiliation_string | Service de Biochimie et de Biologie Moléculaire, Laboratoire de Biologie Médicale MultiSites, Hospices Civils de Lyon, F-69677 Bron, France |
| authorships[9].institutions[0].id | https://openalex.org/I4210100596 |
| authorships[9].institutions[0].ror | https://ror.org/01502ca60 |
| authorships[9].institutions[0].type | healthcare |
| authorships[9].institutions[0].lineage | https://openalex.org/I4210100596 |
| authorships[9].institutions[0].country_code | FR |
| authorships[9].institutions[0].display_name | Hospices Civils de Lyon |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Charlotte Chatelain |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Service de Biochimie et de Biologie Moléculaire, Laboratoire de Biologie Médicale MultiSites, Hospices Civils de Lyon, F-69677 Bron, France |
| authorships[10].author.id | https://openalex.org/A5078856109 |
| authorships[10].author.orcid | |
| authorships[10].author.display_name | Christine Durand |
| authorships[10].countries | FR |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I100532134, https://openalex.org/I154526488, https://openalex.org/I48430043 |
| authorships[10].affiliations[0].raw_affiliation_string | CarMen Laboratory, INSERM, INRA, INSA Lyon, Université Claude Bernard Lyon 1, Pierre-Bénite, F-69364 Lyon, France |
| authorships[10].institutions[0].id | https://openalex.org/I154526488 |
| authorships[10].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[10].institutions[0].type | government |
| authorships[10].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[10].institutions[0].country_code | FR |
| authorships[10].institutions[0].display_name | Inserm |
| authorships[10].institutions[1].id | https://openalex.org/I48430043 |
| authorships[10].institutions[1].ror | https://ror.org/050jn9y42 |
| authorships[10].institutions[1].type | education |
| authorships[10].institutions[1].lineage | https://openalex.org/I203339264, https://openalex.org/I48430043 |
| authorships[10].institutions[1].country_code | FR |
| authorships[10].institutions[1].display_name | Institut National des Sciences Appliquées de Lyon |
| authorships[10].institutions[2].id | https://openalex.org/I100532134 |
| authorships[10].institutions[2].ror | https://ror.org/029brtt94 |
| authorships[10].institutions[2].type | education |
| authorships[10].institutions[2].lineage | https://openalex.org/I100532134, https://openalex.org/I203339264 |
| authorships[10].institutions[2].country_code | FR |
| authorships[10].institutions[2].display_name | Université Claude Bernard Lyon 1 |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Christine Durand |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | CarMen Laboratory, INSERM, INRA, INSA Lyon, Université Claude Bernard Lyon 1, Pierre-Bénite, F-69364 Lyon, France |
| authorships[11].author.id | https://openalex.org/A5014793652 |
| authorships[11].author.orcid | https://orcid.org/0000-0003-0148-9787 |
| authorships[11].author.display_name | Pierre Lindenbaum |
| authorships[11].countries | FR |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I4210144168, https://openalex.org/I97188460 |
| authorships[11].affiliations[0].raw_affiliation_string | Institut du Thorax, Nantes Université, CNRS, INSERM, F-44000 Nantes, France |
| authorships[11].institutions[0].id | https://openalex.org/I1294671590 |
| authorships[11].institutions[0].ror | https://ror.org/02feahw73 |
| authorships[11].institutions[0].type | government |
| authorships[11].institutions[0].lineage | https://openalex.org/I1294671590 |
| authorships[11].institutions[0].country_code | FR |
| authorships[11].institutions[0].display_name | Centre National de la Recherche Scientifique |
| authorships[11].institutions[1].id | https://openalex.org/I154526488 |
| authorships[11].institutions[1].ror | https://ror.org/02vjkv261 |
| authorships[11].institutions[1].type | government |
| authorships[11].institutions[1].lineage | https://openalex.org/I154526488 |
| authorships[11].institutions[1].country_code | FR |
| authorships[11].institutions[1].display_name | Inserm |
| authorships[11].institutions[2].id | https://openalex.org/I4210144168 |
| authorships[11].institutions[2].ror | https://ror.org/049kkt456 |
| authorships[11].institutions[2].type | facility |
| authorships[11].institutions[2].lineage | https://openalex.org/I1294671590, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I4210096427, https://openalex.org/I4210144168, https://openalex.org/I97188460 |
| authorships[11].institutions[2].country_code | FR |
| authorships[11].institutions[2].display_name | Institut du Thorax |
| authorships[11].institutions[3].id | https://openalex.org/I97188460 |
| authorships[11].institutions[3].ror | https://ror.org/03gnr7b55 |
| authorships[11].institutions[3].type | education |
| authorships[11].institutions[3].lineage | https://openalex.org/I97188460 |
| authorships[11].institutions[3].country_code | FR |
| authorships[11].institutions[3].display_name | Nantes Université |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Pierre Lindenbaum |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Institut du Thorax, Nantes Université, CNRS, INSERM, F-44000 Nantes, France |
| authorships[12].author.id | https://openalex.org/A5025087906 |
| authorships[12].author.orcid | https://orcid.org/0000-0002-1587-2253 |
| authorships[12].author.display_name | Jennifer Rieusset |
| authorships[12].countries | FR |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I100532134, https://openalex.org/I154526488, https://openalex.org/I48430043 |
| authorships[12].affiliations[0].raw_affiliation_string | CarMen Laboratory, INSERM, INRA, INSA Lyon, Université Claude Bernard Lyon 1, Pierre-Bénite, F-69364 Lyon, France |
| authorships[12].institutions[0].id | https://openalex.org/I154526488 |
| authorships[12].institutions[0].ror | https://ror.org/02vjkv261 |
| authorships[12].institutions[0].type | government |
| authorships[12].institutions[0].lineage | https://openalex.org/I154526488 |
| authorships[12].institutions[0].country_code | FR |
| authorships[12].institutions[0].display_name | Inserm |
| authorships[12].institutions[1].id | https://openalex.org/I48430043 |
| authorships[12].institutions[1].ror | https://ror.org/050jn9y42 |
| authorships[12].institutions[1].type | education |
| authorships[12].institutions[1].lineage | https://openalex.org/I203339264, https://openalex.org/I48430043 |
| authorships[12].institutions[1].country_code | FR |
| authorships[12].institutions[1].display_name | Institut National des Sciences Appliquées de Lyon |
| authorships[12].institutions[2].id | https://openalex.org/I100532134 |
| authorships[12].institutions[2].ror | https://ror.org/029brtt94 |
| authorships[12].institutions[2].type | education |
| authorships[12].institutions[2].lineage | https://openalex.org/I100532134, https://openalex.org/I203339264 |
| authorships[12].institutions[2].country_code | FR |
| authorships[12].institutions[2].display_name | Université Claude Bernard Lyon 1 |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Jennifer Rieusset |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | CarMen Laboratory, INSERM, INRA, INSA Lyon, Université Claude Bernard Lyon 1, Pierre-Bénite, F-69364 Lyon, France |
| authorships[13].author.id | https://openalex.org/A5004521406 |
| authorships[13].author.orcid | https://orcid.org/0000-0002-1580-8040 |
| authorships[13].author.display_name | Bertrand Cariou |
| authorships[13].countries | FR |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I4210144168, https://openalex.org/I97188460 |
| authorships[13].affiliations[0].raw_affiliation_string | Institut du Thorax, Nantes Université, CHU Nantes, CNRS, INSERM, F-44000 Nantes, France |
| authorships[13].institutions[0].id | https://openalex.org/I1294671590 |
| authorships[13].institutions[0].ror | https://ror.org/02feahw73 |
| authorships[13].institutions[0].type | government |
| authorships[13].institutions[0].lineage | https://openalex.org/I1294671590 |
| authorships[13].institutions[0].country_code | FR |
| authorships[13].institutions[0].display_name | Centre National de la Recherche Scientifique |
| authorships[13].institutions[1].id | https://openalex.org/I154526488 |
| authorships[13].institutions[1].ror | https://ror.org/02vjkv261 |
| authorships[13].institutions[1].type | government |
| authorships[13].institutions[1].lineage | https://openalex.org/I154526488 |
| authorships[13].institutions[1].country_code | FR |
| authorships[13].institutions[1].display_name | Inserm |
| authorships[13].institutions[2].id | https://openalex.org/I4210144168 |
| authorships[13].institutions[2].ror | https://ror.org/049kkt456 |
| authorships[13].institutions[2].type | facility |
| authorships[13].institutions[2].lineage | https://openalex.org/I1294671590, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I4210096427, https://openalex.org/I4210144168, https://openalex.org/I97188460 |
| authorships[13].institutions[2].country_code | FR |
| authorships[13].institutions[2].display_name | Institut du Thorax |
| authorships[13].institutions[3].id | https://openalex.org/I97188460 |
| authorships[13].institutions[3].ror | https://ror.org/03gnr7b55 |
| authorships[13].institutions[3].type | education |
| authorships[13].institutions[3].lineage | https://openalex.org/I97188460 |
| authorships[13].institutions[3].country_code | FR |
| authorships[13].institutions[3].display_name | Nantes Université |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Bertrand Cariou |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Institut du Thorax, Nantes Université, CHU Nantes, CNRS, INSERM, F-44000 Nantes, France |
| authorships[14].author.id | https://openalex.org/A5027600205 |
| authorships[14].author.orcid | https://orcid.org/0000-0002-8344-7814 |
| authorships[14].author.display_name | Philippe Moulin |
| authorships[14].countries | FR |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I4210100596, https://openalex.org/I4210136143 |
| authorships[14].affiliations[0].raw_affiliation_string | Fédération d’Endocrinologie, Maladies Métaboliques, Diabète et Nutrition, Hôpital Louis Pradel, Hospices Civils de Lyon, F-69677 Bron, France |
| authorships[14].affiliations[1].institution_ids | https://openalex.org/I100532134, https://openalex.org/I154526488, https://openalex.org/I48430043 |
| authorships[14].affiliations[1].raw_affiliation_string | CarMen Laboratory, INSERM, INRA, INSA Lyon, Université Claude Bernard Lyon 1, Pierre-Bénite, F-69364 Lyon, France |
| authorships[14].institutions[0].id | https://openalex.org/I4210100596 |
| authorships[14].institutions[0].ror | https://ror.org/01502ca60 |
| authorships[14].institutions[0].type | healthcare |
| authorships[14].institutions[0].lineage | https://openalex.org/I4210100596 |
| authorships[14].institutions[0].country_code | FR |
| authorships[14].institutions[0].display_name | Hospices Civils de Lyon |
| authorships[14].institutions[1].id | https://openalex.org/I4210136143 |
| authorships[14].institutions[1].ror | https://ror.org/0396v4y86 |
| authorships[14].institutions[1].type | healthcare |
| authorships[14].institutions[1].lineage | https://openalex.org/I4210100596, https://openalex.org/I4210136143 |
| authorships[14].institutions[1].country_code | FR |
| authorships[14].institutions[1].display_name | Hôpital Louis Pradel |
| authorships[14].institutions[2].id | https://openalex.org/I154526488 |
| authorships[14].institutions[2].ror | https://ror.org/02vjkv261 |
| authorships[14].institutions[2].type | government |
| authorships[14].institutions[2].lineage | https://openalex.org/I154526488 |
| authorships[14].institutions[2].country_code | FR |
| authorships[14].institutions[2].display_name | Inserm |
| authorships[14].institutions[3].id | https://openalex.org/I48430043 |
| authorships[14].institutions[3].ror | https://ror.org/050jn9y42 |
| authorships[14].institutions[3].type | education |
| authorships[14].institutions[3].lineage | https://openalex.org/I203339264, https://openalex.org/I48430043 |
| authorships[14].institutions[3].country_code | FR |
| authorships[14].institutions[3].display_name | Institut National des Sciences Appliquées de Lyon |
| authorships[14].institutions[4].id | https://openalex.org/I100532134 |
| authorships[14].institutions[4].ror | https://ror.org/029brtt94 |
| authorships[14].institutions[4].type | education |
| authorships[14].institutions[4].lineage | https://openalex.org/I100532134, https://openalex.org/I203339264 |
| authorships[14].institutions[4].country_code | FR |
| authorships[14].institutions[4].display_name | Université Claude Bernard Lyon 1 |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Philippe Moulin |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | CarMen Laboratory, INSERM, INRA, INSA Lyon, Université Claude Bernard Lyon 1, Pierre-Bénite, F-69364 Lyon, France, Fédération d’Endocrinologie, Maladies Métaboliques, Diabète et Nutrition, Hôpital Louis Pradel, Hospices Civils de Lyon, F-69677 Bron, France |
| authorships[15].author.id | https://openalex.org/A5048607035 |
| authorships[15].author.orcid | https://orcid.org/0000-0001-6206-5908 |
| authorships[15].author.display_name | Mathilde Di Filippo |
| authorships[15].countries | FR |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I4210100596 |
| authorships[15].affiliations[0].raw_affiliation_string | Service de Biochimie et de Biologie Moléculaire, Laboratoire de Biologie Médicale MultiSites, Hospices Civils de Lyon, F-69677 Bron, France |
| authorships[15].affiliations[1].institution_ids | https://openalex.org/I100532134, https://openalex.org/I154526488, https://openalex.org/I48430043 |
| authorships[15].affiliations[1].raw_affiliation_string | CarMen Laboratory, INSERM, INRA, INSA Lyon, Université Claude Bernard Lyon 1, Pierre-Bénite, F-69364 Lyon, France |
| authorships[15].institutions[0].id | https://openalex.org/I4210100596 |
| authorships[15].institutions[0].ror | https://ror.org/01502ca60 |
| authorships[15].institutions[0].type | healthcare |
| authorships[15].institutions[0].lineage | https://openalex.org/I4210100596 |
| authorships[15].institutions[0].country_code | FR |
| authorships[15].institutions[0].display_name | Hospices Civils de Lyon |
| authorships[15].institutions[1].id | https://openalex.org/I154526488 |
| authorships[15].institutions[1].ror | https://ror.org/02vjkv261 |
| authorships[15].institutions[1].type | government |
| authorships[15].institutions[1].lineage | https://openalex.org/I154526488 |
| authorships[15].institutions[1].country_code | FR |
| authorships[15].institutions[1].display_name | Inserm |
| authorships[15].institutions[2].id | https://openalex.org/I48430043 |
| authorships[15].institutions[2].ror | https://ror.org/050jn9y42 |
| authorships[15].institutions[2].type | education |
| authorships[15].institutions[2].lineage | https://openalex.org/I203339264, https://openalex.org/I48430043 |
| authorships[15].institutions[2].country_code | FR |
| authorships[15].institutions[2].display_name | Institut National des Sciences Appliquées de Lyon |
| authorships[15].institutions[3].id | https://openalex.org/I100532134 |
| authorships[15].institutions[3].ror | https://ror.org/029brtt94 |
| authorships[15].institutions[3].type | education |
| authorships[15].institutions[3].lineage | https://openalex.org/I100532134, https://openalex.org/I203339264 |
| authorships[15].institutions[3].country_code | FR |
| authorships[15].institutions[3].display_name | Université Claude Bernard Lyon 1 |
| authorships[15].author_position | last |
| authorships[15].raw_author_name | Mathilde Di Filippo |
| authorships[15].is_corresponding | True |
| authorships[15].raw_affiliation_strings | CarMen Laboratory, INSERM, INRA, INSA Lyon, Université Claude Bernard Lyon 1, Pierre-Bénite, F-69364 Lyon, France, Service de Biochimie et de Biologie Moléculaire, Laboratoire de Biologie Médicale MultiSites, Hospices Civils de Lyon, F-69677 Bron, France |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/1422-0067/23/8/4281/pdf?version=1649829661 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2022-04-19T00:00:00 |
| display_name | APOB CRISPR-Cas9 Engineering in Hypobetalipoproteinemia: A Promising Tool for Functional Studies of Novel Variants |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10878 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9976999759674072 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | CRISPR and Genetic Engineering |
| related_works | https://openalex.org/W4391375266, https://openalex.org/W2082860237, https://openalex.org/W4293199045, https://openalex.org/W2405656580, https://openalex.org/W3162049976, https://openalex.org/W2642604616, https://openalex.org/W4401091785, https://openalex.org/W2119695867, https://openalex.org/W4213036952, https://openalex.org/W4377030018 |
| cited_by_count | 10 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 1 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 6 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 1 |
| locations_count | 6 |
| best_oa_location.id | doi:10.3390/ijms23084281 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S10623703 |
| best_oa_location.source.issn | 1422-0067, 1661-6596 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1422-0067 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | International Journal of Molecular Sciences |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/1422-0067/23/8/4281/pdf?version=1649829661 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | International Journal of Molecular Sciences |
| best_oa_location.landing_page_url | https://doi.org/10.3390/ijms23084281 |
| primary_location.id | doi:10.3390/ijms23084281 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S10623703 |
| primary_location.source.issn | 1422-0067, 1661-6596 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1422-0067 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | International Journal of Molecular Sciences |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/1422-0067/23/8/4281/pdf?version=1649829661 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | International Journal of Molecular Sciences |
| primary_location.landing_page_url | https://doi.org/10.3390/ijms23084281 |
| publication_date | 2022-04-13 |
| publication_year | 2022 |
| referenced_works | https://openalex.org/W2789584981, https://openalex.org/W3102574891, https://openalex.org/W4297820108, https://openalex.org/W2009953267, https://openalex.org/W2001569469, https://openalex.org/W1977761476, https://openalex.org/W173549243, https://openalex.org/W2796633818, https://openalex.org/W2082542914, https://openalex.org/W2305216237, https://openalex.org/W2131747785, https://openalex.org/W2050005611, https://openalex.org/W2025486291, https://openalex.org/W1968480313, https://openalex.org/W2009997321, https://openalex.org/W1859156177, https://openalex.org/W2018171920, https://openalex.org/W2082857385, https://openalex.org/W2946343948, https://openalex.org/W2141137906, https://openalex.org/W2110124859, https://openalex.org/W6719338201, https://openalex.org/W2099359234, https://openalex.org/W2011123011, https://openalex.org/W2147811207, https://openalex.org/W2029172671, https://openalex.org/W2051978340, https://openalex.org/W2044394206, https://openalex.org/W2089990478, https://openalex.org/W2187075330, https://openalex.org/W2014946489, https://openalex.org/W3083874241, https://openalex.org/W2462638919, https://openalex.org/W4205786115, https://openalex.org/W2094005985, https://openalex.org/W2021662620, https://openalex.org/W2926211224, https://openalex.org/W3155973491, https://openalex.org/W2922991470, https://openalex.org/W2908524400, https://openalex.org/W4213051184, https://openalex.org/W2909194804, https://openalex.org/W2905452503, https://openalex.org/W2103441770, https://openalex.org/W1919257374, https://openalex.org/W2106578986, https://openalex.org/W2235737683, https://openalex.org/W3131055609, https://openalex.org/W2768718979, https://openalex.org/W2127547407, https://openalex.org/W1803102843, https://openalex.org/W2936956377, https://openalex.org/W1977709885, https://openalex.org/W3049280090, https://openalex.org/W1968278182, https://openalex.org/W2124756133, https://openalex.org/W52583280, https://openalex.org/W4307106829 |
| referenced_works_count | 58 |
| abstract_inverted_index.B | 7 |
| abstract_inverted_index.a | 33, 45, 61, 80, 86, 137, 151, 187 |
| abstract_inverted_index.We | 56, 78, 89 |
| abstract_inverted_index.as | 180 |
| abstract_inverted_index.by | 3, 25, 110, 122 |
| abstract_inverted_index.in | 29, 85, 124, 132, 140, 160, 190, 207 |
| abstract_inverted_index.is | 1, 22 |
| abstract_inverted_index.of | 52, 68, 74, 197, 211, 217 |
| abstract_inverted_index.to | 59, 64, 175, 184, 205 |
| abstract_inverted_index.up | 186 |
| abstract_inverted_index.us | 174 |
| abstract_inverted_index.40% | 152 |
| abstract_inverted_index.70% | 123 |
| abstract_inverted_index.PCR | 113 |
| abstract_inverted_index.The | 117, 145 |
| abstract_inverted_index.VUS | 69 |
| abstract_inverted_index.age | 16 |
| abstract_inverted_index.and | 5, 17, 39, 94, 102, 108, 114, 129, 143, 156, 163, 183, 213 |
| abstract_inverted_index.for | 15 |
| abstract_inverted_index.led | 173 |
| abstract_inverted_index.new | 178 |
| abstract_inverted_index.set | 185 |
| abstract_inverted_index.the | 12, 30, 66, 71, 104, 125, 133, 166, 169, 194, 208, 214 |
| abstract_inverted_index.was | 120 |
| abstract_inverted_index.(KO) | 93 |
| abstract_inverted_index.APOB | 31, 49, 91, 105, 118, 154 |
| abstract_inverted_index.FHBL | 46, 87, 212 |
| abstract_inverted_index.Huh7 | 97 |
| abstract_inverted_index.apoB | 141, 158, 170 |
| abstract_inverted_index.here | 57 |
| abstract_inverted_index.lead | 204 |
| abstract_inverted_index.many | 42 |
| abstract_inverted_index.sex. | 18 |
| abstract_inverted_index.this | 177, 191 |
| abstract_inverted_index.will | 203 |
| abstract_inverted_index.with | 36, 44, 136, 150 |
| abstract_inverted_index.ELISA | 115 |
| abstract_inverted_index.Thus, | 165 |
| abstract_inverted_index.aimed | 58 |
| abstract_inverted_index.below | 11 |
| abstract_inverted_index.carry | 48 |
| abstract_inverted_index.cells | 98, 128, 148 |
| abstract_inverted_index.fatty | 37 |
| abstract_inverted_index.fifth | 13 |
| abstract_inverted_index.gene, | 32 |
| abstract_inverted_index.human | 75 |
| abstract_inverted_index.liver | 38, 76 |
| abstract_inverted_index.novel | 81 |
| abstract_inverted_index.these | 218 |
| abstract_inverted_index.using | 70, 99, 200 |
| abstract_inverted_index.which | 172 |
| abstract_inverted_index.(FHBL) | 21 |
| abstract_inverted_index.(VUS). | 55 |
| abstract_inverted_index.(apoB) | 8 |
| abstract_inverted_index.almost | 130 |
| abstract_inverted_index.assess | 65 |
| abstract_inverted_index.caused | 24 |
| abstract_inverted_index.cells, | 135 |
| abstract_inverted_index.cells. | 77 |
| abstract_inverted_index.codons | 28 |
| abstract_inverted_index.genome | 72 |
| abstract_inverted_index.levels | 10, 159 |
| abstract_inverted_index.likely | 181 |
| abstract_inverted_index.mostly | 23 |
| abstract_inverted_index.plasma | 9 |
| abstract_inverted_index.APOB-KO | 127 |
| abstract_inverted_index.develop | 60 |
| abstract_inverted_index.digital | 111 |
| abstract_inverted_index.droplet | 112 |
| abstract_inverted_index.editing | 73 |
| abstract_inverted_index.family. | 88, 192 |
| abstract_inverted_index.hepatic | 188 |
| abstract_inverted_index.studied | 103 |
| abstract_inverted_index.variant | 179 |
| abstract_inverted_index.APOB-VUS | 83 |
| abstract_inverted_index.Familial | 19 |
| abstract_inverted_index.affected | 168 |
| abstract_inverted_index.cellular | 161 |
| abstract_inverted_index.classify | 176 |
| abstract_inverted_index.decrease | 139 |
| abstract_inverted_index.extracts | 162 |
| abstract_inverted_index.families | 43 |
| abstract_inverted_index.knock-in | 96 |
| abstract_inverted_index.missense | 50 |
| abstract_inverted_index.variants | 51 |
| abstract_inverted_index.abolished | 131 |
| abstract_inverted_index.condition | 34 |
| abstract_inverted_index.decreased | 121, 153 |
| abstract_inverted_index.diagnosis | 210 |
| abstract_inverted_index.follow-up | 189, 216 |
| abstract_inverted_index.generated | 90 |
| abstract_inverted_index.knock-out | 92 |
| abstract_inverted_index.molecular | 209 |
| abstract_inverted_index.patients. | 219 |
| abstract_inverted_index.phenotype | 47 |
| abstract_inverted_index.premature | 26 |
| abstract_inverted_index.presented | 149 |
| abstract_inverted_index.secretion | 109 |
| abstract_inverted_index.synthesis | 107 |
| abstract_inverted_index.uncertain | 53 |
| abstract_inverted_index.variants, | 199 |
| abstract_inverted_index.Therefore, | 193 |
| abstract_inverted_index.assessment | 196 |
| abstract_inverted_index.associated | 35 |
| abstract_inverted_index.consistent | 138 |
| abstract_inverted_index.experiment | 63 |
| abstract_inverted_index.expression | 119, 155 |
| abstract_inverted_index.functional | 195 |
| abstract_inverted_index.homozygous | 147 |
| abstract_inverted_index.identified | 79 |
| abstract_inverted_index.pathogenic | 182 |
| abstract_inverted_index.percentile | 14 |
| abstract_inverted_index.production | 142 |
| abstract_inverted_index.secretion, | 171 |
| abstract_inverted_index.secretion. | 144 |
| abstract_inverted_index.technology | 101 |
| abstract_inverted_index.CRISPR-Cas9 | 100 |
| abstract_inverted_index.expression, | 106 |
| abstract_inverted_index.p.Leu351Arg | 167 |
| abstract_inverted_index.termination | 27 |
| abstract_inverted_index.gene-editing | 201 |
| abstract_inverted_index.heterozygous | 82, 126 |
| abstract_inverted_index.improvements | 206 |
| abstract_inverted_index.personalized | 215 |
| abstract_inverted_index.significance | 54 |
| abstract_inverted_index.supernatant. | 164 |
| abstract_inverted_index.undetectable | 157 |
| abstract_inverted_index.APOB-missense | 198 |
| abstract_inverted_index.Nevertheless, | 41 |
| abstract_inverted_index.characterized | 2 |
| abstract_inverted_index.homozygous-KO | 134 |
| abstract_inverted_index.pathogenicity | 67 |
| abstract_inverted_index.technologies, | 202 |
| abstract_inverted_index.(p.Leu351Arg), | 84 |
| abstract_inverted_index.apolipoprotein | 6 |
| abstract_inverted_index.LDL-cholesterol | 4 |
| abstract_inverted_index.quantification. | 116 |
| abstract_inverted_index.APOB-p.Leu351Arg | 95, 146 |
| abstract_inverted_index.steatohepatitis. | 40 |
| abstract_inverted_index.proof-of-principle | 62 |
| abstract_inverted_index.Hypobetalipoproteinemia | 0 |
| abstract_inverted_index.hypobetalipoproteinemia | 20 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5048607035 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 16 |
| corresponding_institution_ids | https://openalex.org/I100532134, https://openalex.org/I154526488, https://openalex.org/I4210100596, https://openalex.org/I48430043 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6399999856948853 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.72891976 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |