APOE2 act as inhibitors to microglial LDAM transition by restricting LD accumulation Article Swipe
Recent studies have suggested the relationship between genetic risk factors related to lipid droplets accumulation such as APOE4 and Alzheimers disease pathology. However, whether certain APOE variants act as inhibitors of transition to LDAM by limiting LD accumulation remains unknown. This paper raises a research proposal for this question by trying to illustrate it in two steps. First, experiments performing immunostaining on mice suggest that APOE2 could limit lipid accumulation, proving that APOE2 could efficiently clear myelin debris and microgliosis is dramatically increased upon acute demyelination. Then, several experiments are performed to prove that limited lipid accumulation could reduce microglial LDAM transition, illustrating that the differences in ability of phagocytosis, ROS production and immune signaling exist if there are differences in the content of lipid accumulation. Finally, some insights about the related therapies are mentioned. If the hypothesis in the proposal is proved to be true, some related potential therapeutic strategies for treating Alzheimers disease would appear.
Related Topics
Concepts
Microglia
Transition (genetics)
Disease
Alzheimer's disease
Phagocytosis
Limiting
Lipid accumulation
Neuroscience
Myelin
Apolipoprotein E
Lipid metabolism
Immunostaining
Biology
Immunology
Medicine
Pathology
Genetics
Biochemistry
Gene
Central nervous system
Immunohistochemistry
Engineering
Mechanical engineering
Inflammation
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.54254/2753-8818/2024.19962
- https://www.ewadirect.com/proceedings/tns/article/view/19962/pdf
- OA Status
- hybrid
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4406248326
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4406248326Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.54254/2753-8818/2024.19962Digital Object Identifier
- Title
-
APOE2 act as inhibitors to microglial LDAM transition by restricting LD accumulationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-01-10Full publication date if available
- Authors
-
Ziqi ZhouList of authors in order
- Landing page
-
https://doi.org/10.54254/2753-8818/2024.19962Publisher landing page
- PDF URL
-
https://www.ewadirect.com/proceedings/tns/article/view/19962/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://www.ewadirect.com/proceedings/tns/article/view/19962/pdfDirect OA link when available
- Concepts
-
Microglia, Transition (genetics), Disease, Alzheimer's disease, Phagocytosis, Limiting, Lipid accumulation, Neuroscience, Myelin, Apolipoprotein E, Lipid metabolism, Immunostaining, Biology, Immunology, Medicine, Pathology, Genetics, Biochemistry, Gene, Central nervous system, Immunohistochemistry, Engineering, Mechanical engineering, InflammationTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.proving | 70 |
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| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5101664132 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 1 |
| corresponding_institution_ids | https://openalex.org/I3132008252 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7799999713897705 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.00614859 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |