Arbitration between model-free and model-based control is not affected by transient changes in tonic serotonin levels Article Swipe
Maximilian Gilger
,
Lydia Hellrung
,
Philipp T. Neukam
,
Nils B. Kroemer
,
Stephan Nebe
,
Shakoor Pooseh
,
Yacila I. Deza-Lougovski
,
Michael N. Smolka
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1177/02698811231216325
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1177/02698811231216325
Background: Serotonin has been suggested to modulate decision-making by influencing the arbitration between model-based and model-free control. Disruptions in these control mechanisms are involved in mental disorders such as drug dependence or obsessive-compulsive disorder. While previous reports indicate that lower brain serotonin levels reduce model-based control, it remains unknown whether increases in serotonergic availability might thus increase model-based control. Moreover, the mediating neural mechanisms have not been studied yet. Aim: The first aim of this study was to investigate whether increased/decreased tonic serotonin levels affect the arbitration between model-free and model-based control. Second, we aimed to identify the underlying neural processes. Methods: We employed a sequential two-stage Markov decision-task and measured brain responses during functional magnetic resonance imaging in 98 participants in a randomized, double-blind cross-over within-subject design. To investigate the influence of serotonin on the balance between model-free and model-based control, we used a tryptophan intervention with three intervention levels (loading, balanced, depletion). We hypothesized that model-based behaviour would increase with higher serotonin levels. Results: We found evidence that neither model-free nor model-based control were affected by changes in tonic serotonin levels. Furthermore, our tryptophan intervention did not elicit relevant changes in Blood-Oxygenation-Level Dependent activity.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1177/02698811231216325
- https://journals.sagepub.com/doi/pdf/10.1177/02698811231216325
- OA Status
- hybrid
- Cited By
- 3
- References
- 59
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4390341711
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4390341711Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1177/02698811231216325Digital Object Identifier
- Title
-
Arbitration between model-free and model-based control is not affected by transient changes in tonic serotonin levelsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-12-27Full publication date if available
- Authors
-
Maximilian Gilger, Lydia Hellrung, Philipp T. Neukam, Nils B. Kroemer, Stephan Nebe, Shakoor Pooseh, Yacila I. Deza-Lougovski, Michael N. SmolkaList of authors in order
- Landing page
-
https://doi.org/10.1177/02698811231216325Publisher landing page
- PDF URL
-
https://journals.sagepub.com/doi/pdf/10.1177/02698811231216325Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://journals.sagepub.com/doi/pdf/10.1177/02698811231216325Direct OA link when available
- Concepts
-
Serotonergic, Serotonin, Tonic (physiology), Psychology, Functional magnetic resonance imaging, Neuroscience, Internal medicine, Medicine, ReceptorTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3Per-year citation counts (last 5 years)
- References (count)
-
59Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4390341711 |
|---|---|
| doi | https://doi.org/10.1177/02698811231216325 |
| ids.doi | https://doi.org/10.1177/02698811231216325 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/38151862 |
| ids.openalex | https://openalex.org/W4390341711 |
| fwci | 0.63099586 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D014364 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Tryptophan |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D012701 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Serotonin |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D017008 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Negotiating |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D001921 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Brain |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D009771 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Obsessive-Compulsive Disorder |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D004311 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Double-Blind Method |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D018592 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Cross-Over Studies |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D006801 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Humans |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D014364 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Tryptophan |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D012701 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Serotonin |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D017008 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Negotiating |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D001921 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Brain |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D009771 |
| mesh[13].is_major_topic | True |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Obsessive-Compulsive Disorder |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D004311 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Double-Blind Method |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D018592 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Cross-Over Studies |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D006801 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Humans |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D014364 |
| mesh[17].is_major_topic | True |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Tryptophan |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D012701 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Serotonin |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D017008 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Negotiating |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D001921 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Brain |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D009771 |
| mesh[21].is_major_topic | True |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Obsessive-Compulsive Disorder |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D004311 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Double-Blind Method |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D018592 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Cross-Over Studies |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D006801 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Humans |
| mesh[25].qualifier_ui | |
| mesh[25].descriptor_ui | D014364 |
| mesh[25].is_major_topic | True |
| mesh[25].qualifier_name | |
| mesh[25].descriptor_name | Tryptophan |
| mesh[26].qualifier_ui | |
| mesh[26].descriptor_ui | D012701 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | |
| mesh[26].descriptor_name | Serotonin |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D017008 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Negotiating |
| mesh[28].qualifier_ui | |
| mesh[28].descriptor_ui | D001921 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | |
| mesh[28].descriptor_name | Brain |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D009771 |
| mesh[29].is_major_topic | True |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Obsessive-Compulsive Disorder |
| mesh[30].qualifier_ui | |
| mesh[30].descriptor_ui | D004311 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | |
| mesh[30].descriptor_name | Double-Blind Method |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D018592 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | Cross-Over Studies |
| type | article |
| title | Arbitration between model-free and model-based control is not affected by transient changes in tonic serotonin levels |
| awards[0].id | https://openalex.org/G7777021748 |
| awards[0].funder_id | https://openalex.org/F4320320879 |
| awards[0].display_name | |
| awards[0].funder_award_id | 402170461 |
| awards[0].funder_display_name | Deutsche Forschungsgemeinschaft |
| biblio.issue | 2 |
| biblio.volume | 38 |
| biblio.last_page | 187 |
| biblio.first_page | 178 |
| topics[0].id | https://openalex.org/T10056 |
| topics[0].field.id | https://openalex.org/fields/28 |
| topics[0].field.display_name | Neuroscience |
| topics[0].score | 0.9984999895095825 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2804 |
| topics[0].subfield.display_name | Cellular and Molecular Neuroscience |
| topics[0].display_name | Neurotransmitter Receptor Influence on Behavior |
| topics[1].id | https://openalex.org/T10042 |
| topics[1].field.id | https://openalex.org/fields/28 |
| topics[1].field.display_name | Neuroscience |
| topics[1].score | 0.9983000159263611 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2805 |
| topics[1].subfield.display_name | Cognitive Neuroscience |
| topics[1].display_name | Neural and Behavioral Psychology Studies |
| topics[2].id | https://openalex.org/T13283 |
| topics[2].field.id | https://openalex.org/fields/32 |
| topics[2].field.display_name | Psychology |
| topics[2].score | 0.9979000091552734 |
| topics[2].domain.id | https://openalex.org/domains/2 |
| topics[2].domain.display_name | Social Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/3205 |
| topics[2].subfield.display_name | Experimental and Cognitive Psychology |
| topics[2].display_name | Mental Health Research Topics |
| funders[0].id | https://openalex.org/F4320320879 |
| funders[0].ror | https://ror.org/018mejw64 |
| funders[0].display_name | Deutsche Forschungsgemeinschaft |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C37000724 |
| concepts[0].level | 4 |
| concepts[0].score | 0.8582472801208496 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q50430226 |
| concepts[0].display_name | Serotonergic |
| concepts[1].id | https://openalex.org/C2775864247 |
| concepts[1].level | 3 |
| concepts[1].score | 0.8329944610595703 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q167934 |
| concepts[1].display_name | Serotonin |
| concepts[2].id | https://openalex.org/C127573956 |
| concepts[2].level | 2 |
| concepts[2].score | 0.7369992136955261 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q7821376 |
| concepts[2].display_name | Tonic (physiology) |
| concepts[3].id | https://openalex.org/C15744967 |
| concepts[3].level | 0 |
| concepts[3].score | 0.601235568523407 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q9418 |
| concepts[3].display_name | Psychology |
| concepts[4].id | https://openalex.org/C2779226451 |
| concepts[4].level | 2 |
| concepts[4].score | 0.4778546988964081 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q903809 |
| concepts[4].display_name | Functional magnetic resonance imaging |
| concepts[5].id | https://openalex.org/C169760540 |
| concepts[5].level | 1 |
| concepts[5].score | 0.3582421541213989 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q207011 |
| concepts[5].display_name | Neuroscience |
| concepts[6].id | https://openalex.org/C126322002 |
| concepts[6].level | 1 |
| concepts[6].score | 0.23950842022895813 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[6].display_name | Internal medicine |
| concepts[7].id | https://openalex.org/C71924100 |
| concepts[7].level | 0 |
| concepts[7].score | 0.23246479034423828 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[7].display_name | Medicine |
| concepts[8].id | https://openalex.org/C170493617 |
| concepts[8].level | 2 |
| concepts[8].score | 0.0 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q208467 |
| concepts[8].display_name | Receptor |
| keywords[0].id | https://openalex.org/keywords/serotonergic |
| keywords[0].score | 0.8582472801208496 |
| keywords[0].display_name | Serotonergic |
| keywords[1].id | https://openalex.org/keywords/serotonin |
| keywords[1].score | 0.8329944610595703 |
| keywords[1].display_name | Serotonin |
| keywords[2].id | https://openalex.org/keywords/tonic |
| keywords[2].score | 0.7369992136955261 |
| keywords[2].display_name | Tonic (physiology) |
| keywords[3].id | https://openalex.org/keywords/psychology |
| keywords[3].score | 0.601235568523407 |
| keywords[3].display_name | Psychology |
| keywords[4].id | https://openalex.org/keywords/functional-magnetic-resonance-imaging |
| keywords[4].score | 0.4778546988964081 |
| keywords[4].display_name | Functional magnetic resonance imaging |
| keywords[5].id | https://openalex.org/keywords/neuroscience |
| keywords[5].score | 0.3582421541213989 |
| keywords[5].display_name | Neuroscience |
| keywords[6].id | https://openalex.org/keywords/internal-medicine |
| keywords[6].score | 0.23950842022895813 |
| keywords[6].display_name | Internal medicine |
| keywords[7].id | https://openalex.org/keywords/medicine |
| keywords[7].score | 0.23246479034423828 |
| keywords[7].display_name | Medicine |
| language | en |
| locations[0].id | doi:10.1177/02698811231216325 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S136368880 |
| locations[0].source.issn | 0269-8811, 1461-7285 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0269-8811 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Journal of Psychopharmacology |
| locations[0].source.host_organization | https://openalex.org/P4310320017 |
| locations[0].source.host_organization_name | SAGE Publishing |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320017 |
| locations[0].source.host_organization_lineage_names | SAGE Publishing |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://journals.sagepub.com/doi/pdf/10.1177/02698811231216325 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Journal of Psychopharmacology |
| locations[0].landing_page_url | https://doi.org/10.1177/02698811231216325 |
| locations[1].id | pmid:38151862 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Journal of psychopharmacology (Oxford, England) |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/38151862 |
| locations[2].id | pmh:oai:www.zora.uzh.ch:254730 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306401281 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Zurich Open Repository and Archive (University of Zurich) |
| locations[2].source.host_organization | https://openalex.org/I202697423 |
| locations[2].source.host_organization_name | University of Zurich |
| locations[2].source.host_organization_lineage | https://openalex.org/I202697423 |
| locations[2].license | cc-by |
| locations[2].pdf_url | |
| locations[2].version | publishedVersion |
| locations[2].raw_type | info:eu-repo/semantics/publishedVersion |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | True |
| locations[2].is_published | True |
| locations[2].raw_source_name | Gilger, Maximilian D; Hellrung, Lydia; Neukam, Philipp T; Kroemer, Nils B; Nebe, Stephan; Pooseh, Shakoor; Deza-Lougovski, Yacila I; Smolka, Michael N (2024). Arbitration between model-free and model-based control is not affected by transient changes in tonic serotonin levels. Journal of Psychopharmacology, 38(2):178-187. |
| locations[2].landing_page_url | |
| locations[3].id | pmh:oai:pubmedcentral.nih.gov:10863371 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S2764455111 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | PubMed Central |
| locations[3].source.host_organization | https://openalex.org/I1299303238 |
| locations[3].source.host_organization_name | National Institutes of Health |
| locations[3].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[3].license | cc-by |
| locations[3].pdf_url | https://pmc.ncbi.nlm.nih.gov/articles/PMC10863371/pdf/10.1177_02698811231216325.pdf |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/cc-by |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | J Psychopharmacol |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/10863371 |
| locations[4].id | doi:10.5167/uzh-254730 |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S7407051291 |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | Universität Zürich, ZORA |
| locations[4].source.host_organization | |
| locations[4].source.host_organization_name | |
| locations[4].license | |
| locations[4].pdf_url | |
| locations[4].version | |
| locations[4].raw_type | article-journal |
| locations[4].license_id | |
| locations[4].is_accepted | False |
| locations[4].is_published | |
| locations[4].raw_source_name | |
| locations[4].landing_page_url | https://doi.org/10.5167/uzh-254730 |
| indexed_in | crossref, datacite, pubmed |
| authorships[0].author.id | https://openalex.org/A5008202926 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Maximilian Gilger |
| authorships[0].countries | DE |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I78650965 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany |
| authorships[0].institutions[0].id | https://openalex.org/I78650965 |
| authorships[0].institutions[0].ror | https://ror.org/042aqky30 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I78650965 |
| authorships[0].institutions[0].country_code | DE |
| authorships[0].institutions[0].display_name | Technische Universität Dresden |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Maximilian D. Gilger |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany |
| authorships[1].author.id | https://openalex.org/A5004225993 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-0317-4770 |
| authorships[1].author.display_name | Lydia Hellrung |
| authorships[1].countries | CH |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I202697423 |
| authorships[1].affiliations[0].raw_affiliation_string | Zurich Center for Neuroeconomics, Department of Economics, University of Zurich, Zurich, Switzerland |
| authorships[1].institutions[0].id | https://openalex.org/I202697423 |
| authorships[1].institutions[0].ror | https://ror.org/02crff812 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I202697423 |
| authorships[1].institutions[0].country_code | CH |
| authorships[1].institutions[0].display_name | University of Zurich |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Lydia Hellrung |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Zurich Center for Neuroeconomics, Department of Economics, University of Zurich, Zurich, Switzerland |
| authorships[2].author.id | https://openalex.org/A5045705783 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-9442-0043 |
| authorships[2].author.display_name | Philipp T. Neukam |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210157321, https://openalex.org/I98704320 |
| authorships[2].affiliations[0].raw_affiliation_string | Depression and Anxiety Center for Discovery and Treatment, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA |
| authorships[2].institutions[0].id | https://openalex.org/I4210157321 |
| authorships[2].institutions[0].ror | https://ror.org/04jna0a58 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210157321 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Center for Discovery |
| authorships[2].institutions[1].id | https://openalex.org/I98704320 |
| authorships[2].institutions[1].ror | https://ror.org/04a9tmd77 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I1320796813, https://openalex.org/I98704320 |
| authorships[2].institutions[1].country_code | US |
| authorships[2].institutions[1].display_name | Icahn School of Medicine at Mount Sinai |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Philipp T. Neukam |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Depression and Anxiety Center for Discovery and Treatment, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA |
| authorships[3].author.id | https://openalex.org/A5077959151 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-9552-3781 |
| authorships[3].author.display_name | Nils B. Kroemer |
| authorships[3].countries | DE |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I135140700 |
| authorships[3].affiliations[0].raw_affiliation_string | Section of Medical Psychology, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Bonn, Bonn, Germany |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I4210160326 |
| authorships[3].affiliations[1].raw_affiliation_string | German Center for Mental Health (DZPG), Tübingen, Germany |
| authorships[3].affiliations[2].institution_ids | https://openalex.org/I8087733 |
| authorships[3].affiliations[2].raw_affiliation_string | Department of Psychiatry and Psychotherapy, Tübingen Center for Mental Health, University of Tübingen, Tübingen, Germany |
| authorships[3].institutions[0].id | https://openalex.org/I4210160326 |
| authorships[3].institutions[0].ror | https://ror.org/04qq88z54 |
| authorships[3].institutions[0].type | facility |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210160326, https://openalex.org/I4411590659 |
| authorships[3].institutions[0].country_code | DE |
| authorships[3].institutions[0].display_name | German Center for Diabetes Research |
| authorships[3].institutions[1].id | https://openalex.org/I135140700 |
| authorships[3].institutions[1].ror | https://ror.org/041nas322 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I135140700 |
| authorships[3].institutions[1].country_code | DE |
| authorships[3].institutions[1].display_name | University of Bonn |
| authorships[3].institutions[2].id | https://openalex.org/I8087733 |
| authorships[3].institutions[2].ror | https://ror.org/03a1kwz48 |
| authorships[3].institutions[2].type | education |
| authorships[3].institutions[2].lineage | https://openalex.org/I8087733 |
| authorships[3].institutions[2].country_code | DE |
| authorships[3].institutions[2].display_name | University of Tübingen |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Nils B. Kroemer |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Psychiatry and Psychotherapy, Tübingen Center for Mental Health, University of Tübingen, Tübingen, Germany, German Center for Mental Health (DZPG), Tübingen, Germany, Section of Medical Psychology, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Bonn, Bonn, Germany |
| authorships[4].author.id | https://openalex.org/A5007147561 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-3968-9557 |
| authorships[4].author.display_name | Stephan Nebe |
| authorships[4].countries | CH |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I202697423 |
| authorships[4].affiliations[0].raw_affiliation_string | Zurich Center for Neuroeconomics, Department of Economics, University of Zurich, Zurich, Switzerland |
| authorships[4].institutions[0].id | https://openalex.org/I202697423 |
| authorships[4].institutions[0].ror | https://ror.org/02crff812 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I202697423 |
| authorships[4].institutions[0].country_code | CH |
| authorships[4].institutions[0].display_name | University of Zurich |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Stephan Nebe |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Zurich Center for Neuroeconomics, Department of Economics, University of Zurich, Zurich, Switzerland |
| authorships[5].author.id | https://openalex.org/A5016321891 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-5441-9507 |
| authorships[5].author.display_name | Shakoor Pooseh |
| authorships[5].countries | DE |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I161046081 |
| authorships[5].affiliations[0].raw_affiliation_string | Freiburg Center for Data Analysis and Modelling, Institute of Physics, University of Freiburg, Freiburg, Germany |
| authorships[5].institutions[0].id | https://openalex.org/I161046081 |
| authorships[5].institutions[0].ror | https://ror.org/0245cg223 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I161046081 |
| authorships[5].institutions[0].country_code | DE |
| authorships[5].institutions[0].display_name | University of Freiburg |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Shakoor Pooseh |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Freiburg Center for Data Analysis and Modelling, Institute of Physics, University of Freiburg, Freiburg, Germany |
| authorships[6].author.id | https://openalex.org/A5093602110 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Yacila I. Deza-Lougovski |
| authorships[6].countries | DE |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I78650965 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I40527276 |
| authorships[6].affiliations[1].raw_affiliation_string | Institute of Psychology, University of the Bundeswehr München, Neubiberg, Germany |
| authorships[6].institutions[0].id | https://openalex.org/I78650965 |
| authorships[6].institutions[0].ror | https://ror.org/042aqky30 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I78650965 |
| authorships[6].institutions[0].country_code | DE |
| authorships[6].institutions[0].display_name | Technische Universität Dresden |
| authorships[6].institutions[1].id | https://openalex.org/I40527276 |
| authorships[6].institutions[1].ror | https://ror.org/05kkv3f82 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I1315109972, https://openalex.org/I40527276, https://openalex.org/I4387152969 |
| authorships[6].institutions[1].country_code | DE |
| authorships[6].institutions[1].display_name | Universität der Bundeswehr München |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Yacila I. Deza-Lougovski |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany, Institute of Psychology, University of the Bundeswehr München, Neubiberg, Germany |
| authorships[7].author.id | https://openalex.org/A5063406820 |
| authorships[7].author.orcid | https://orcid.org/0000-0001-5398-5569 |
| authorships[7].author.display_name | Michael N. Smolka |
| authorships[7].countries | DE |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I78650965 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany |
| authorships[7].institutions[0].id | https://openalex.org/I78650965 |
| authorships[7].institutions[0].ror | https://ror.org/042aqky30 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I78650965 |
| authorships[7].institutions[0].country_code | DE |
| authorships[7].institutions[0].display_name | Technische Universität Dresden |
| authorships[7].author_position | last |
| authorships[7].raw_author_name | Michael N. Smolka |
| authorships[7].is_corresponding | True |
| authorships[7].raw_affiliation_strings | Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://journals.sagepub.com/doi/pdf/10.1177/02698811231216325 |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Arbitration between model-free and model-based control is not affected by transient changes in tonic serotonin levels |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10056 |
| primary_topic.field.id | https://openalex.org/fields/28 |
| primary_topic.field.display_name | Neuroscience |
| primary_topic.score | 0.9984999895095825 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2804 |
| primary_topic.subfield.display_name | Cellular and Molecular Neuroscience |
| primary_topic.display_name | Neurotransmitter Receptor Influence on Behavior |
| related_works | https://openalex.org/W2081701126, https://openalex.org/W2072185657, https://openalex.org/W2027364088, https://openalex.org/W2046239958, https://openalex.org/W2014541695, https://openalex.org/W1493607353, https://openalex.org/W4281957879, https://openalex.org/W2394615032, https://openalex.org/W2254887992, https://openalex.org/W4253625985 |
| cited_by_count | 3 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 3 |
| locations_count | 5 |
| best_oa_location.id | doi:10.1177/02698811231216325 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S136368880 |
| best_oa_location.source.issn | 0269-8811, 1461-7285 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 0269-8811 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Journal of Psychopharmacology |
| best_oa_location.source.host_organization | https://openalex.org/P4310320017 |
| best_oa_location.source.host_organization_name | SAGE Publishing |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320017 |
| best_oa_location.source.host_organization_lineage_names | SAGE Publishing |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://journals.sagepub.com/doi/pdf/10.1177/02698811231216325 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Journal of Psychopharmacology |
| best_oa_location.landing_page_url | https://doi.org/10.1177/02698811231216325 |
| primary_location.id | doi:10.1177/02698811231216325 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S136368880 |
| primary_location.source.issn | 0269-8811, 1461-7285 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0269-8811 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Journal of Psychopharmacology |
| primary_location.source.host_organization | https://openalex.org/P4310320017 |
| primary_location.source.host_organization_name | SAGE Publishing |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320017 |
| primary_location.source.host_organization_lineage_names | SAGE Publishing |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://journals.sagepub.com/doi/pdf/10.1177/02698811231216325 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Journal of Psychopharmacology |
| primary_location.landing_page_url | https://doi.org/10.1177/02698811231216325 |
| publication_date | 2023-12-27 |
| publication_year | 2023 |
| referenced_works | https://openalex.org/W2057001461, https://openalex.org/W1630806950, https://openalex.org/W2177703847, https://openalex.org/W4294214781, https://openalex.org/W2082179080, https://openalex.org/W3122554617, https://openalex.org/W2009480086, https://openalex.org/W2053170041, https://openalex.org/W2167362547, https://openalex.org/W2077611535, https://openalex.org/W2102803424, https://openalex.org/W2013293748, https://openalex.org/W2906360411, https://openalex.org/W2005055606, https://openalex.org/W1988699227, https://openalex.org/W2003048056, https://openalex.org/W1977391299, https://openalex.org/W2016770860, https://openalex.org/W2146676986, https://openalex.org/W2288341381, https://openalex.org/W2113619522, https://openalex.org/W2086615576, https://openalex.org/W2068086593, https://openalex.org/W1995234726, https://openalex.org/W2012546389, https://openalex.org/W2952293280, https://openalex.org/W2434627633, https://openalex.org/W2088448721, https://openalex.org/W1985108516, https://openalex.org/W2061257589, https://openalex.org/W2580932073, https://openalex.org/W2157840419, https://openalex.org/W2801148615, https://openalex.org/W2974990191, https://openalex.org/W2051068515, https://openalex.org/W3144238310, https://openalex.org/W2017108196, https://openalex.org/W2148407573, https://openalex.org/W1964979700, https://openalex.org/W2117726420, https://openalex.org/W2557614148, https://openalex.org/W2103492232, https://openalex.org/W2025175823, https://openalex.org/W3012976897, https://openalex.org/W2000214310, https://openalex.org/W2069879324, https://openalex.org/W2039051284, https://openalex.org/W1986459850, https://openalex.org/W2022881357, https://openalex.org/W2131803813, https://openalex.org/W2010147753, https://openalex.org/W2071359470, https://openalex.org/W1978219303, https://openalex.org/W2080834410, https://openalex.org/W2098020453, https://openalex.org/W2487016276, https://openalex.org/W1982230115, https://openalex.org/W1919166334, https://openalex.org/W2010247009 |
| referenced_works_count | 59 |
| abstract_inverted_index.a | 104, 122, 144 |
| abstract_inverted_index.98 | 119 |
| abstract_inverted_index.To | 128 |
| abstract_inverted_index.We | 102, 154, 166 |
| abstract_inverted_index.as | 28 |
| abstract_inverted_index.by | 8, 177 |
| abstract_inverted_index.in | 18, 24, 51, 118, 121, 179, 192 |
| abstract_inverted_index.it | 46 |
| abstract_inverted_index.of | 73, 132 |
| abstract_inverted_index.on | 134 |
| abstract_inverted_index.or | 31 |
| abstract_inverted_index.to | 5, 77, 95 |
| abstract_inverted_index.we | 93, 142 |
| abstract_inverted_index.The | 70 |
| abstract_inverted_index.aim | 72 |
| abstract_inverted_index.and | 14, 89, 109, 139 |
| abstract_inverted_index.are | 22 |
| abstract_inverted_index.did | 187 |
| abstract_inverted_index.has | 2 |
| abstract_inverted_index.nor | 172 |
| abstract_inverted_index.not | 65, 188 |
| abstract_inverted_index.our | 184 |
| abstract_inverted_index.the | 10, 60, 85, 97, 130, 135 |
| abstract_inverted_index.was | 76 |
| abstract_inverted_index.Aim: | 69 |
| abstract_inverted_index.been | 3, 66 |
| abstract_inverted_index.drug | 29 |
| abstract_inverted_index.have | 64 |
| abstract_inverted_index.such | 27 |
| abstract_inverted_index.that | 38, 156, 169 |
| abstract_inverted_index.this | 74 |
| abstract_inverted_index.thus | 55 |
| abstract_inverted_index.used | 143 |
| abstract_inverted_index.were | 175 |
| abstract_inverted_index.with | 147, 161 |
| abstract_inverted_index.yet. | 68 |
| abstract_inverted_index.While | 34 |
| abstract_inverted_index.aimed | 94 |
| abstract_inverted_index.brain | 40, 111 |
| abstract_inverted_index.first | 71 |
| abstract_inverted_index.found | 167 |
| abstract_inverted_index.lower | 39 |
| abstract_inverted_index.might | 54 |
| abstract_inverted_index.study | 75 |
| abstract_inverted_index.these | 19 |
| abstract_inverted_index.three | 148 |
| abstract_inverted_index.tonic | 81, 180 |
| abstract_inverted_index.would | 159 |
| abstract_inverted_index.Markov | 107 |
| abstract_inverted_index.affect | 84 |
| abstract_inverted_index.during | 113 |
| abstract_inverted_index.elicit | 189 |
| abstract_inverted_index.higher | 162 |
| abstract_inverted_index.levels | 42, 83, 150 |
| abstract_inverted_index.mental | 25 |
| abstract_inverted_index.neural | 62, 99 |
| abstract_inverted_index.reduce | 43 |
| abstract_inverted_index.Second, | 92 |
| abstract_inverted_index.balance | 136 |
| abstract_inverted_index.between | 12, 87, 137 |
| abstract_inverted_index.changes | 178, 191 |
| abstract_inverted_index.control | 20, 174 |
| abstract_inverted_index.design. | 127 |
| abstract_inverted_index.imaging | 117 |
| abstract_inverted_index.levels. | 164, 182 |
| abstract_inverted_index.neither | 170 |
| abstract_inverted_index.remains | 47 |
| abstract_inverted_index.reports | 36 |
| abstract_inverted_index.studied | 67 |
| abstract_inverted_index.unknown | 48 |
| abstract_inverted_index.whether | 49, 79 |
| abstract_inverted_index.Methods: | 101 |
| abstract_inverted_index.Results: | 165 |
| abstract_inverted_index.affected | 176 |
| abstract_inverted_index.control, | 45, 141 |
| abstract_inverted_index.control. | 16, 58, 91 |
| abstract_inverted_index.employed | 103 |
| abstract_inverted_index.evidence | 168 |
| abstract_inverted_index.identify | 96 |
| abstract_inverted_index.increase | 56, 160 |
| abstract_inverted_index.indicate | 37 |
| abstract_inverted_index.involved | 23 |
| abstract_inverted_index.magnetic | 115 |
| abstract_inverted_index.measured | 110 |
| abstract_inverted_index.modulate | 6 |
| abstract_inverted_index.previous | 35 |
| abstract_inverted_index.relevant | 190 |
| abstract_inverted_index.(loading, | 151 |
| abstract_inverted_index.Dependent | 194 |
| abstract_inverted_index.Moreover, | 59 |
| abstract_inverted_index.Serotonin | 1 |
| abstract_inverted_index.activity. | 195 |
| abstract_inverted_index.balanced, | 152 |
| abstract_inverted_index.behaviour | 158 |
| abstract_inverted_index.disorder. | 33 |
| abstract_inverted_index.disorders | 26 |
| abstract_inverted_index.increases | 50 |
| abstract_inverted_index.influence | 131 |
| abstract_inverted_index.mediating | 61 |
| abstract_inverted_index.resonance | 116 |
| abstract_inverted_index.responses | 112 |
| abstract_inverted_index.serotonin | 41, 82, 133, 163, 181 |
| abstract_inverted_index.suggested | 4 |
| abstract_inverted_index.two-stage | 106 |
| abstract_inverted_index.cross-over | 125 |
| abstract_inverted_index.dependence | 30 |
| abstract_inverted_index.functional | 114 |
| abstract_inverted_index.mechanisms | 21, 63 |
| abstract_inverted_index.model-free | 15, 88, 138, 171 |
| abstract_inverted_index.processes. | 100 |
| abstract_inverted_index.sequential | 105 |
| abstract_inverted_index.tryptophan | 145, 185 |
| abstract_inverted_index.underlying | 98 |
| abstract_inverted_index.Background: | 0 |
| abstract_inverted_index.Disruptions | 17 |
| abstract_inverted_index.arbitration | 11, 86 |
| abstract_inverted_index.depletion). | 153 |
| abstract_inverted_index.influencing | 9 |
| abstract_inverted_index.investigate | 78, 129 |
| abstract_inverted_index.model-based | 13, 44, 57, 90, 140, 157, 173 |
| abstract_inverted_index.randomized, | 123 |
| abstract_inverted_index.Furthermore, | 183 |
| abstract_inverted_index.availability | 53 |
| abstract_inverted_index.double-blind | 124 |
| abstract_inverted_index.hypothesized | 155 |
| abstract_inverted_index.intervention | 146, 149, 186 |
| abstract_inverted_index.participants | 120 |
| abstract_inverted_index.serotonergic | 52 |
| abstract_inverted_index.decision-task | 108 |
| abstract_inverted_index.within-subject | 126 |
| abstract_inverted_index.decision-making | 7 |
| abstract_inverted_index.increased/decreased | 80 |
| abstract_inverted_index.obsessive-compulsive | 32 |
| abstract_inverted_index.Blood-Oxygenation-Level | 193 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 96 |
| corresponding_author_ids | https://openalex.org/A5063406820 |
| countries_distinct_count | 3 |
| institutions_distinct_count | 8 |
| corresponding_institution_ids | https://openalex.org/I78650965 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/16 |
| sustainable_development_goals[0].score | 0.6399999856948853 |
| sustainable_development_goals[0].display_name | Peace, Justice and strong institutions |
| citation_normalized_percentile.value | 0.6505578 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |