Are We Ready With Prevention for Type 1 Diabetes? Article Swipe
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/dmrr.70101
Definitive prevention for type 1 diabetes (T1D) is not yet available, but we are now entering a new era where disease‐modifying therapies are becoming available in T1D to halt disease progression. In this review, we present up‐to‐date knowledge related to the prevention of T1D in youth, involving disease‐modifying therapies at different T1D stages. A narrative literature review utilising the PubMed/MEDLINE database was performed using the keywords ‘screening’, ‘prevention’, ‘Disease‐modifying therapy’, and ‘Diabetes Mellitus, Type 1’ [Mesh] in youth aged 0–18 years. Only teplizumab has been approved by the FDA as the first drug shown to delay the onset of Stage 3 T1D. Other monoclonal antibodies targeting specific immune cells, agents targeting specific cytokines, antigen‐specific therapies, and immunomodulant and/or immunosuppressive agents have been studied alone or in combination to control or delay the progression of beta‐cell destruction. In individuals with Stage 3 T1D, several intervention trials have led to a temporary improvement in beta‐cell function, but this benefit has consistently been short‐lived. Ongoing and future research will be essential to refine patient selection, identify additional therapeutic targets, and optimise the timing and durability of immunotherapy responses.
Related Topics
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enPrimary language
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2025-10-01Full publication date if available
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Evelina Maines, Roberto Franceschi, Francesca Di Candia, Enza MozzilloList of authors in order
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0Total citation count in OpenAlex
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| abstract_inverted_index.and | 71, 116, 163, 177, 181 |
| abstract_inverted_index.are | 14, 23 |
| abstract_inverted_index.but | 12, 155 |
| abstract_inverted_index.era | 19 |
| abstract_inverted_index.for | 3 |
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| abstract_inverted_index.led | 147 |
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| abstract_inverted_index.the | 41, 59, 65, 88, 91, 97, 132, 179 |
| abstract_inverted_index.was | 62 |
| abstract_inverted_index.yet | 10 |
| abstract_inverted_index.1’ | 75 |
| abstract_inverted_index.Only | 82 |
| abstract_inverted_index.T1D, | 142 |
| abstract_inverted_index.T1D. | 102 |
| abstract_inverted_index.Type | 74 |
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| abstract_inverted_index.drug | 93 |
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| abstract_inverted_index.have | 121, 146 |
| abstract_inverted_index.this | 33, 156 |
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| abstract_inverted_index.will | 166 |
| abstract_inverted_index.with | 139 |
| abstract_inverted_index.(T1D) | 7 |
| abstract_inverted_index.Other | 103 |
| abstract_inverted_index.Stage | 100, 140 |
| abstract_inverted_index.alone | 124 |
| abstract_inverted_index.delay | 96, 131 |
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| abstract_inverted_index.onset | 98 |
| abstract_inverted_index.shown | 94 |
| abstract_inverted_index.using | 64 |
| abstract_inverted_index.where | 20 |
| abstract_inverted_index.youth | 78 |
| abstract_inverted_index.0–18 | 80 |
| abstract_inverted_index.[Mesh] | 76 |
| abstract_inverted_index.agents | 110, 120 |
| abstract_inverted_index.and/or | 118 |
| abstract_inverted_index.cells, | 109 |
| abstract_inverted_index.future | 164 |
| abstract_inverted_index.immune | 108 |
| abstract_inverted_index.refine | 170 |
| abstract_inverted_index.review | 57 |
| abstract_inverted_index.timing | 180 |
| abstract_inverted_index.trials | 145 |
| abstract_inverted_index.years. | 81 |
| abstract_inverted_index.youth, | 46 |
| abstract_inverted_index.Ongoing | 162 |
| abstract_inverted_index.benefit | 157 |
| abstract_inverted_index.control | 129 |
| abstract_inverted_index.disease | 30 |
| abstract_inverted_index.patient | 171 |
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| abstract_inverted_index.related | 39 |
| abstract_inverted_index.review, | 34 |
| abstract_inverted_index.several | 143 |
| abstract_inverted_index.stages. | 53 |
| abstract_inverted_index.studied | 123 |
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| abstract_inverted_index.entering | 16 |
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| abstract_inverted_index.keywords | 66 |
| abstract_inverted_index.optimise | 178 |
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| abstract_inverted_index.targets, | 176 |
| abstract_inverted_index.Mellitus, | 73 |
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| abstract_inverted_index.function, | 154 |
| abstract_inverted_index.involving | 47 |
| abstract_inverted_index.knowledge | 38 |
| abstract_inverted_index.narrative | 55 |
| abstract_inverted_index.performed | 63 |
| abstract_inverted_index.targeting | 106, 111 |
| abstract_inverted_index.temporary | 150 |
| abstract_inverted_index.therapies | 22, 49 |
| abstract_inverted_index.utilising | 58 |
| abstract_inverted_index.Definitive | 1 |
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| abstract_inverted_index.antibodies | 105 |
| abstract_inverted_index.available, | 11 |
| abstract_inverted_index.cytokines, | 113 |
| abstract_inverted_index.durability | 182 |
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| abstract_inverted_index.prevention | 2, 42 |
| abstract_inverted_index.responses. | 185 |
| abstract_inverted_index.selection, | 172 |
| abstract_inverted_index.teplizumab | 83 |
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| abstract_inverted_index.up‐to‐date | 37 |
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| abstract_inverted_index.immunosuppressive | 119 |
| abstract_inverted_index.‘prevention’, | 68 |
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| abstract_inverted_index.‘Disease‐modifying | 69 |
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| countries_distinct_count | 1 |
| institutions_distinct_count | 4 |
| citation_normalized_percentile.value | 0.53169014 |
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| citation_normalized_percentile.is_in_top_10_percent | True |