β-Arrestin2 is increased in liver fibrosis in humans and rodents Article Swipe
Robert Schierwagen
,
Peter Dietrich
,
Sabine Klein
,
Frank Erhard Uschner
,
Cristina Ortiz
,
Olaf Tyc
,
Sandra Torres
,
Claus Hellerbrand
,
Tilman Sauerbruch
,
Jonel Trebicka
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.2014337117
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.2014337117
Liu et al. (1) elegantly present that β-arrestin2 (β-Arr2) is critical for endothelial nitric oxide synthase (eNOS) activation of liver sinusoidal endothelial cells (LSEC). The authors demonstrate a relationship between decreased β-Arr2 expression in LSEC and decreased intrahepatic eNOS activity and NO formation contributing to the development of portal hypertension, and offer β-Arr2 as a target to promote eNOS activity and to improve portal hypertension. Interestingly, β-Arr2 expressed in extrahepatic tissue is also involved in portal hypertension. Its up-regulation in endothelium-denuded splanchnic vessels probably induces splanchnic vasodilation and contributes to aggravation of portal hypertension, largely NO independent (2). Furthermore, in antral mucosa, increased β-Arr2 expression seems to be related to portal hypertension (3, 4). These data demonstrate that β-Arr2 has different functions in different tissues and cell types. Regarding the whole liver and in contrast to the findings in LSEC, hepatic β-Arr2 expression is increased … [↵][1]1To whom correspondence may be addressed. Email: jonel.trebicka{at}kgu.de. [1]: #xref-corresp-1-1
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- Type
- letter
- Language
- en
- Landing Page
- https://doi.org/10.1073/pnas.2014337117
- https://www.pnas.org/content/pnas/117/44/27082.full.pdf
- OA Status
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- Cited By
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- References
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- Related Works
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- OpenAlex ID
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- Title
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β-Arrestin2 is increased in liver fibrosis in humans and rodentsWork title
- Type
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letterOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-11-03Full publication date if available
- Authors
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Robert Schierwagen, Peter Dietrich, Sabine Klein, Frank Erhard Uschner, Cristina Ortiz, Olaf Tyc, Sandra Torres, Claus Hellerbrand, Tilman Sauerbruch, Jonel TrebickaList of authors in order
- Landing page
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https://doi.org/10.1073/pnas.2014337117Publisher landing page
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https://www.pnas.org/content/pnas/117/44/27082.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://www.pnas.org/content/pnas/117/44/27082.full.pdfDirect OA link when available
- Concepts
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Liver fibrosis, Biology, Medicine, Fibrosis, PathologyTop concepts (fields/topics) attached by OpenAlex
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12Total citation count in OpenAlex
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2024: 4, 2023: 4, 2022: 1, 2021: 2, 2020: 1Per-year citation counts (last 5 years)
- References (count)
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10Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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