Artemether attenuates renal tubular injury by targeting mitochondria in adriamycin nephropathy mice. Article Swipe
Xinyuan Cheng
,
Peng Zhou
,
Wenci Weng
,
Zhijian Sun
,
Honghong Liu
,
Yinghui Chen
,
Yuchun Cai
,
Xuewen Yu
,
Taifen Wang
,
Mumin Shao
,
Wuyong Yi
,
Tiegang Yi
,
Huili Sun
,
Pengxun Han
·
YOU?
·
· 2022
· Open Access
·
YOU?
·
· 2022
· Open Access
·
Chronic kidney disease (CKD) is complex and current treatment remains limited. As we know, glomerular injury plays a dominant role in kidney disease progression. However, accumulating evidence demonstrated that renal tubules, rather than being victims or bystanders, are major initiators in renal fibrosis progression. Renal tubules are rich in mitochondria and mitochondrial dysfunction may participate in renal tubular phenotypic changes and ultimately promote renal fibrosis. Previous studies have proved that artemether displayed renal protective effects, but the mechanisms remain unclear. In this experiment, we showed that artemether reduced urinary protein/creatinine ratio and attenuated renal tubular injury. Both in vivo and in vitro results indicated that artemether could restore renal tubular phenotypic alterations. Meanwhile, the unbalanced expressions of Bax and Bcl-xL in renal tubules were restored by artemether. In addition, artemether also regulated mitochondrial pyruvate metabolism, increased mitochondrial biogenesis, and improved mitochondrial function. Taken together, this study suggested that artemether could attenuate renal tubular injury by regulating mitochondrial biogenesis and function. It has great potential to be translated to the clinic as a therapeutic agent for treating kidney diseases, especially those associated with renal tubular injury.
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- Type
- article
- Language
- en
- Landing Page
- https://pubmed.ncbi.nlm.nih.gov/35422916
- OA Status
- green
- Cited By
- 4
- References
- 28
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4226208757
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4226208757Canonical identifier for this work in OpenAlex
- Title
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Artemether attenuates renal tubular injury by targeting mitochondria in adriamycin nephropathy mice.Work title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-01-01Full publication date if available
- Authors
-
Xinyuan Cheng, Peng Zhou, Wenci Weng, Zhijian Sun, Honghong Liu, Yinghui Chen, Yuchun Cai, Xuewen Yu, Taifen Wang, Mumin Shao, Wuyong Yi, Tiegang Yi, Huili Sun, Pengxun HanList of authors in order
- Landing page
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https://pubmed.ncbi.nlm.nih.gov/35422916Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/8991145Direct OA link when available
- Concepts
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Artemether, Mitochondrial biogenesis, Renal function, Kidney, Medicine, Mitochondrion, Pharmacology, Kidney disease, Acute kidney injury, Nephrotoxicity, Fibrosis, Internal medicine, Pathology, Biology, Cell biology, Plasmodium falciparum, Artemisinin, MalariaTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2023: 2Per-year citation counts (last 5 years)
- References (count)
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28Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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