Arterial remodelling in smokers and in patients with small airway disease and COPD: implications for lung physiology and early origins of pulmonary hypertension Article Swipe
Prem Bhattarai
,
Wenying Lu
,
Archana Vijay Gaikwad
,
Surajit Dey
,
Collin Chia
,
Josie Larby
,
Greg Haug
,
Ashutosh Hardikar
,
Andrew D. Williams
,
Gurpreet K. Singhera
,
Tillie‐Louise Hackett
,
Mathew Suji Eapen
,
Sukhwinder Singh Sohal
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1183/23120541.00254-2022
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1183/23120541.00254-2022
Introduction Pulmonary vascular remodelling in chronic obstructive pulmonary disease (COPD) has detrimental consequences for lung physiology. The aim of our study was to provide a comprehensive size-based morphometric quantification of pulmonary arterial remodelling in smokers and in patients with small airway disease (SAD) or COPD. Method Movat's pentachrome staining was performed on lung resections for 46 subjects: 12 never-smoker normal controls (NC), six normal lung function smokers (NLFS), nine patients with SAD, nine patients with mild-to-moderate COPD who were current smokers (COPD-CS) and 10 patients with mild-to-moderate COPD who were ex-smokers (COPD-ES). Following a size-based classification of pulmonary arteries, image analysis software was used to measure their number, total wall thickness, individual layer thickness and elastin percentage. Results All pathological groups showed decreased numbers of pulmonary arteries compared with the NC group in all artery sizes. Arterial wall thickness was greater in NLFS and COPD-CS than in NC. Thickness in COPD-ES was decreased compared with COPD-CS. Intimal thickness was greater in all pathological groups in all arterial sizes than in the NC group. Medial thickness was also greater in small and medium arteries. Intimal thickness of larger arteries in COPD-CS correlated negatively to forced expiratory volume in 1 s/forced vital capacity (FVC) % and forced expiratory flow at 25–75% of FVC. Elastin deposition in small arteries was greatest in COPD-CS. Intimal elastin deposition had a more negative correlation with intimal thickness in NLFS and SAD than in COPD-CS. Conclusion Smoking, SAD and mild-to-moderate COPD are associated with pruning and a decrease in the number of pulmonary arteries, increased wall thickness and variable elastin deposition. These changes were associated with worse airway obstruction.
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- Type
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- Language
- en
- Landing Page
- https://doi.org/10.1183/23120541.00254-2022
- https://openres.ersjournals.com/content/erjor/8/4/00254-2022.full.pdf
- OA Status
- gold
- Cited By
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- References
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- Related Works
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- OpenAlex ID
- https://openalex.org/W4302307287
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4302307287Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1183/23120541.00254-2022Digital Object Identifier
- Title
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Arterial remodelling in smokers and in patients with small airway disease and COPD: implications for lung physiology and early origins of pulmonary hypertensionWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
-
2022-10-01Full publication date if available
- Authors
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Prem Bhattarai, Wenying Lu, Archana Vijay Gaikwad, Surajit Dey, Collin Chia, Josie Larby, Greg Haug, Ashutosh Hardikar, Andrew D. Williams, Gurpreet K. Singhera, Tillie‐Louise Hackett, Mathew Suji Eapen, Sukhwinder Singh SohalList of authors in order
- Landing page
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https://doi.org/10.1183/23120541.00254-2022Publisher landing page
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https://openres.ersjournals.com/content/erjor/8/4/00254-2022.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://openres.ersjournals.com/content/erjor/8/4/00254-2022.full.pdfDirect OA link when available
- Concepts
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Medicine, COPD, Elastin, Cardiology, Pulmonary artery, Lung, Internal medicine, Pulmonary function testing, Pathological, Pulmonary hypertension, Vascular remodelling in the embryo, Lung volumes, Airway, Pathology, SurgeryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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21Total citation count in OpenAlex
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2025: 6, 2024: 6, 2023: 9Per-year citation counts (last 5 years)
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51Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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