Artesunate Enhances Sensitivity of Renal Cancer Cells to Sunitnib by Mediating Tripartite Motif Containing 24‐Induced Ubiquitination of Paired Box 6 Article Swipe
Zelin Cui
,
Jianhua Wen
,
Yang Guanglin
,
Liwei Wei
,
Hao Chen
,
Qian Zhao
,
Shubo Yang
,
Jinqiu Yu
,
Yichen Huang
,
Shuting Tan
,
Qianxing Mo
,
Min Qin
,
Jiwen Cheng
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1111/cbdd.70116
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1111/cbdd.70116
This research aims to elucidate the mechanistic role of artesunate (ART) in enhancing the sensitivity of renal cell carcinoma (RCC) to sunitinib. To establish sunitinib‐resistant RCC cell lines (786‐O R and Caki‐1 R), cells were treated with different concentrations of sunitinib and ART. The viability of the cells was measured through the cell counting kit‐8 (CCK‐8) assay. Tripartite motif‐containing 24 (TRIM24) and paired box 6 (PAX6) expression were suppressed with lentiviral vectors, quantified by reverse transcription‐quantitative polymerase chain reaction (RT‐qPCR) and western blot (WB) analysis. TRIM24‐PAX6 interaction was examined through co‐immunoprecipitation (Co‐IP) and deubiquitination assays. Additional assays included colony formation, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining, WB detection of phosphorylated histone H2AX (γ‐H2AX) for DNA damage, epithelial‐mesenchymal transition (EMT) marker analysis, sphere formation, and stemness marker assessments. In vivo drug resistance was tested using a mouse subcutaneous xenograft model. ART enhanced sunitinib sensitivity in resistant RCC cells, reducing colony formation, inducing apoptosis, elevating γ‐H2AX, and upregulating TRIM24. ART enhances sunitinib sensitivity in RCC cells by upregulating TRIM24 expression, which facilitates the ubiquitination of PAX6. This process leads to the suppression of EMT and stem cell‐like transitions in RCC cells.
Related Topics
Concepts
Sunitinib
TUNEL assay
Molecular biology
Viability assay
Cancer research
Cyclin D1
Apoptosis
Cell growth
Biology
Terminal deoxynucleotidyl transferase
MTT assay
Chemistry
Cell cycle
Cancer
Biochemistry
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/cbdd.70116
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cbdd.70116
- OA Status
- bronze
- References
- 33
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4410285760
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4410285760Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1111/cbdd.70116Digital Object Identifier
- Title
-
Artesunate Enhances Sensitivity of Renal Cancer Cells to Sunitnib by Mediating Tripartite Motif Containing 24‐Induced Ubiquitination of Paired Box 6Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-05-01Full publication date if available
- Authors
-
Zelin Cui, Jianhua Wen, Yang Guanglin, Liwei Wei, Hao Chen, Qian Zhao, Shubo Yang, Jinqiu Yu, Yichen Huang, Shuting Tan, Qianxing Mo, Min Qin, Jiwen ChengList of authors in order
- Landing page
-
https://doi.org/10.1111/cbdd.70116Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cbdd.70116Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cbdd.70116Direct OA link when available
- Concepts
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Sunitinib, TUNEL assay, Molecular biology, Viability assay, Cancer research, Cyclin D1, Apoptosis, Cell growth, Biology, Terminal deoxynucleotidyl transferase, MTT assay, Chemistry, Cell cycle, Cancer, Biochemistry, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
33Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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