Ascending Aortic Aneurysm in Relation to Aortic Valve Phenotype Article Swipe
David Freiholtz
,
Per Eriksson
,
Hanna M. Björck
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.5772/intechopen.112883
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.5772/intechopen.112883
Being born with a bicuspid aortic valve (BAV) is a significant risk factor for developing an ascending aortic aneurysm (AscAA). Research has uncovered different mechanisms influencing AscAA development in BAV-patients compared to those with normal tricuspid aortic valves (TAV). BAV-associated AscAA may result from intrinsic hemodynamic or genetic alterations, possibly even embryonic origins. During embryonic development, neural crest cells and the second heart field contribute to the ascending aorta’s formation, with defective signaling potentially increasing susceptibility to aneurysm development. BAV can manifest with different phenotypes, impacting clinical outcomes. The degenerative AscAA in TAV-patients differs from BAV-associated AscAA, marked by fibrosis, smooth muscle cell loss, and inflammation. AscAA in TAV-patients rarely appears in those with aortic stenosis, suggesting a link between aortic valve disease and degenerative AscAA. This chapter aims to describe suggested molecular mechanisms driving aneurysm formation in BAV- and TAV-patients.
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Metadata
- Type
- book-chapter
- Language
- en
- Landing Page
- https://doi.org/10.5772/intechopen.112883
- https://www.intechopen.com/citation-pdf-url/88113
- OA Status
- hybrid
- Cited By
- 1
- References
- 108
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W4391995418Canonical identifier for this work in OpenAlex
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https://doi.org/10.5772/intechopen.112883Digital Object Identifier
- Title
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Ascending Aortic Aneurysm in Relation to Aortic Valve PhenotypeWork title
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book-chapterOpenAlex work type
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enPrimary language
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2024Year of publication
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2024-02-21Full publication date if available
- Authors
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David Freiholtz, Per Eriksson, Hanna M. BjörckList of authors in order
- Landing page
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https://doi.org/10.5772/intechopen.112883Publisher landing page
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https://www.intechopen.com/citation-pdf-url/88113Direct link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://www.intechopen.com/citation-pdf-url/88113Direct OA link when available
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Cardiology, Internal medicine, Aortic valve, Medicine, Aortic aneurysm, Relation (database), Computer science, Aorta, Data miningTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2023: 1Per-year citation counts (last 5 years)
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| abstract_inverted_index.This | 126 |
| abstract_inverted_index.aims | 128 |
| abstract_inverted_index.born | 1 |
| abstract_inverted_index.cell | 102 |
| abstract_inverted_index.even | 50 |
| abstract_inverted_index.from | 43, 94 |
| abstract_inverted_index.link | 118 |
| abstract_inverted_index.risk | 11 |
| abstract_inverted_index.with | 2, 33, 70, 82, 113 |
| abstract_inverted_index.(BAV) | 7 |
| abstract_inverted_index.AscAA | 26, 40, 90, 106 |
| abstract_inverted_index.Being | 0 |
| abstract_inverted_index.cells | 58 |
| abstract_inverted_index.crest | 57 |
| abstract_inverted_index.field | 63 |
| abstract_inverted_index.heart | 62 |
| abstract_inverted_index.loss, | 103 |
| abstract_inverted_index.those | 32, 112 |
| abstract_inverted_index.valve | 6, 121 |
| abstract_inverted_index.(TAV). | 38 |
| abstract_inverted_index.AscAA, | 96 |
| abstract_inverted_index.AscAA. | 125 |
| abstract_inverted_index.During | 53 |
| abstract_inverted_index.aortic | 5, 17, 36, 114, 120 |
| abstract_inverted_index.factor | 12 |
| abstract_inverted_index.marked | 97 |
| abstract_inverted_index.muscle | 101 |
| abstract_inverted_index.neural | 56 |
| abstract_inverted_index.normal | 34 |
| abstract_inverted_index.rarely | 109 |
| abstract_inverted_index.result | 42 |
| abstract_inverted_index.second | 61 |
| abstract_inverted_index.smooth | 100 |
| abstract_inverted_index.valves | 37 |
| abstract_inverted_index.appears | 110 |
| abstract_inverted_index.between | 119 |
| abstract_inverted_index.chapter | 127 |
| abstract_inverted_index.differs | 93 |
| abstract_inverted_index.disease | 122 |
| abstract_inverted_index.driving | 134 |
| abstract_inverted_index.genetic | 47 |
| abstract_inverted_index.(AscAA). | 19 |
| abstract_inverted_index.Research | 20 |
| abstract_inverted_index.aneurysm | 18, 77, 135 |
| abstract_inverted_index.bicuspid | 4 |
| abstract_inverted_index.clinical | 86 |
| abstract_inverted_index.compared | 30 |
| abstract_inverted_index.describe | 130 |
| abstract_inverted_index.manifest | 81 |
| abstract_inverted_index.origins. | 52 |
| abstract_inverted_index.possibly | 49 |
| abstract_inverted_index.aorta’s | 68 |
| abstract_inverted_index.ascending | 16, 67 |
| abstract_inverted_index.defective | 71 |
| abstract_inverted_index.different | 23, 83 |
| abstract_inverted_index.embryonic | 51, 54 |
| abstract_inverted_index.fibrosis, | 99 |
| abstract_inverted_index.formation | 136 |
| abstract_inverted_index.impacting | 85 |
| abstract_inverted_index.intrinsic | 44 |
| abstract_inverted_index.molecular | 132 |
| abstract_inverted_index.outcomes. | 87 |
| abstract_inverted_index.signaling | 72 |
| abstract_inverted_index.stenosis, | 115 |
| abstract_inverted_index.suggested | 131 |
| abstract_inverted_index.tricuspid | 35 |
| abstract_inverted_index.uncovered | 22 |
| abstract_inverted_index.contribute | 64 |
| abstract_inverted_index.developing | 14 |
| abstract_inverted_index.formation, | 69 |
| abstract_inverted_index.increasing | 74 |
| abstract_inverted_index.mechanisms | 24, 133 |
| abstract_inverted_index.suggesting | 116 |
| abstract_inverted_index.development | 27 |
| abstract_inverted_index.hemodynamic | 45 |
| abstract_inverted_index.influencing | 25 |
| abstract_inverted_index.phenotypes, | 84 |
| abstract_inverted_index.potentially | 73 |
| abstract_inverted_index.significant | 10 |
| abstract_inverted_index.BAV-patients | 29 |
| abstract_inverted_index.TAV-patients | 92, 108 |
| abstract_inverted_index.alterations, | 48 |
| abstract_inverted_index.degenerative | 89, 124 |
| abstract_inverted_index.development, | 55 |
| abstract_inverted_index.development. | 78 |
| abstract_inverted_index.TAV-patients. | 140 |
| abstract_inverted_index.inflammation. | 105 |
| abstract_inverted_index.BAV-associated | 39, 95 |
| abstract_inverted_index.susceptibility | 75 |
| cited_by_percentile_year.max | 94 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5050304007 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 3 |
| corresponding_institution_ids | https://openalex.org/I28166907 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7200000286102295 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.04908703 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |