Aseptic Loosening in Total Hip Arthroplasty: Pathophysiology, Biomarkers, and Preventive Treatment Strategies Article Swipe
Gabriele Ricciardi
,
Luca Siracusano
,
Edoardo Micale
,
Vito Addorisio
,
Mariagiovanna Ballato
,
D Donadio
,
Pietro Tralongo
,
Giuseppe Giuffrè
,
Danilo Leonetti
,
Maurizio Martini
,
Biagio Zampogna
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/app15169156
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/app15169156
Aseptic loosening (AL) represents the leading cause of long-term failure in total joint arthroplasty, often necessitating revision surgery. This review explores the complex mechanisms underlying AL, which involve a multifaceted interaction between the implanted biomaterials and the host immune response. We outline the key inflammatory mechanisms triggered by wear debris from polyethylene, polymethylmethacrylate, metal, and ceramic materials. We also examine emerging biomarkers for early detection and differentiation between stable and loosened implants, including proinflammatory cytokines, bone metabolism markers, extracellular matrix degradation products, microRNAs, and genetic polymorphisms. Lastly, we discuss current and future strategies for prevention and treatment, ranging from surgical optimization and biomaterial selection to pharmacological interventions. A comprehensive understanding of these mechanisms may help reduce the incidence of AL and improve long-term outcomes in arthroplasty patients.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/app15169156
- https://www.mdpi.com/2076-3417/15/16/9156/pdf?version=1755825966
- OA Status
- gold
- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4413401618Canonical identifier for this work in OpenAlex
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https://doi.org/10.3390/app15169156Digital Object Identifier
- Title
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Aseptic Loosening in Total Hip Arthroplasty: Pathophysiology, Biomarkers, and Preventive Treatment StrategiesWork title
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
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2025-08-20Full publication date if available
- Authors
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Gabriele Ricciardi, Luca Siracusano, Edoardo Micale, Vito Addorisio, Mariagiovanna Ballato, D Donadio, Pietro Tralongo, Giuseppe Giuffrè, Danilo Leonetti, Maurizio Martini, Biagio ZampognaList of authors in order
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https://doi.org/10.3390/app15169156Publisher landing page
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https://www.mdpi.com/2076-3417/15/16/9156/pdf?version=1755825966Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2076-3417/15/16/9156/pdf?version=1755825966Direct OA link when available
- Concepts
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Medicine, Total hip arthroplasty, Arthroplasty, Intensive care medicine, SurgeryTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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