Assembly and Stability of Simian Virus 40 Polymorphs Article Swipe
Curt Waltmann
,
Roi Asor
,
Uri Raviv
,
Mónica Olvera de la Cruz
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1021/acsnano.9b10004
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1021/acsnano.9b10004
Understanding viral assembly pathways is of critical importance to biology, medicine, and nanotechology. Here, we study the assembly path of a system with various structures, the simian vacuolating virus 40 (SV40) polymorphs. We simulate the templated assembly process of VP1 pentamers, which are the constituents of SV40, into icosahedal shells made of N = 12 pentamers (T = 1). The simulations include connections formed between pentamers by C-terminal flexible lateral units, termed here "C-terminal ligands", which are shown to control assembly behavior and shell dynamics. The model also incorporates electrostatic attractions between the N-terminal peptide strands (ligands) and the negatively charged cargo, allowing for agreement with experiments of RNA templated assembly at various pH and ionic conditions. During viral assembly, pentamers bound to any template increase its effective size due to the length and flexibility of the C-terminal ligands, which can connect to other VP1 pentamers and recruit them to a partially completed capsid. All closed shells formed other than the T = 1 feature the ability to dynamically rearrange and are thus termed "pseudo-closed". The N = 13 shell can even spontaneously "self-correct" by losing a pentamer and become a T = 1 capsid when the template size fluctuates. Bound pentamers recruiting additional pentamers to dynamically rearranging capsids allow closed shells to continue growing via the pseudo-closed growth mechanism, for which experimental evidence already exists. Overall, we show that the C-terminal ligands control the dynamic assembly paths of SV40 polymorphs.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/acsnano.9b10004
- OA Status
- green
- Cited By
- 19
- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W3013916171Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1021/acsnano.9b10004Digital Object Identifier
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Assembly and Stability of Simian Virus 40 PolymorphsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-03-25Full publication date if available
- Authors
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Curt Waltmann, Roi Asor, Uri Raviv, Mónica Olvera de la CruzList of authors in order
- Landing page
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https://doi.org/10.1021/acsnano.9b10004Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
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https://www.ncbi.nlm.nih.gov/pmc/articles/7232851Direct OA link when available
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Pentamer, Capsid, Crystallography, Molecular dynamics, Biophysics, Chemistry, Materials science, Nanotechnology, Biology, Biochemistry, Gene, Computational chemistryTop concepts (fields/topics) attached by OpenAlex
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19Total citation count in OpenAlex
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2025: 4, 2024: 3, 2023: 4, 2022: 2, 2021: 5Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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