Assessing Oncologists’ Adoption of Biomarker Testing in Metastatic Colorectal Cancer Using Real-World Data Article Swipe
Pritish Iyer
,
Mengying Deng
,
Elizabeth A. Handorf
,
Shazia Nakhoda
,
Efrat Dotan
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1093/jncics/pkac065
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1093/jncics/pkac065
Background Despite national guideline recommendations for universal biomarker testing (KRAS, NRAS, BRAF, and mismatch repair and microsatellite instability [MMR/MSI]) in all patients with metastatic colorectal cancer (mCRC), little is known regarding adherence to these recommendations in routine practice. Methods We retrospectively reviewed patients with mCRC diagnosed between January 1, 2013, and December 27, 2018, from a de-identified electronic health record–derived database. We analyzed disparities in KRAS, NRAS, BRAF, and MMR/MSI testing by race, age, sex, and insurance status using χ2 tests and t tests. We evaluated changes in biomarker testing over time with attention to changes around dates of landmark publications and guideline updates using χ2 tests and Cochran-Armitage tests. Results A total of 20 333 patients were identified of which 66.6% had test results for any biomarker. Rates of test results for all 4 biomarkers statistically significantly increased over time (P < .001). However, as of June 30, 2018, the rate of test results was only 46% for NRAS, 56% for KRAS, and 46% for BRAF. As of December 31, 2017, the rate of MMR/MSI testing was 59%. Higher documented testing rates were associated with younger age, lower Eastern Cooperative Oncology Group performance status, and commercial insurance. There were no clinically meaningful and/or statistically significant differences in documented testing rates by tumor sidedness, race, sex, or initial stage. Conclusions Increased rates of documented testing for NRAS, BRAF, and MMR/MSI in mCRC was seen between 2013 and 2018 reflecting adoption of guideline recommendations. However, the rate of documented testing remains lower than expected and warrants additional research to understand the extent to which this may represent a clinical practice quality concern.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/jncics/pkac065
- https://academic.oup.com/jncics/article-pdf/6/6/pkac065/47050261/pkac065.pdf
- OA Status
- gold
- Cited By
- 5
- References
- 49
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4296793600
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4296793600Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/jncics/pkac065Digital Object Identifier
- Title
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Assessing Oncologists’ Adoption of Biomarker Testing in Metastatic Colorectal Cancer Using Real-World DataWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-09-23Full publication date if available
- Authors
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Pritish Iyer, Mengying Deng, Elizabeth A. Handorf, Shazia Nakhoda, Efrat DotanList of authors in order
- Landing page
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https://doi.org/10.1093/jncics/pkac065Publisher landing page
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https://academic.oup.com/jncics/article-pdf/6/6/pkac065/47050261/pkac065.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://academic.oup.com/jncics/article-pdf/6/6/pkac065/47050261/pkac065.pdfDirect OA link when available
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Medicine, Colorectal cancer, Biomarker, Oncology, Internal medicine, Cancer, Chemistry, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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5Total citation count in OpenAlex
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2025: 1, 2024: 2, 2023: 1, 2022: 1Per-year citation counts (last 5 years)
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49Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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