Assessing the <em>In Vitro</em> Cytotoxicity, Antitumoral and Antioxidant Properties of Polyphenol‐rich <em>Perilla leaves </em>Extracts Article Swipe
Gigi Adam
,
Florina-Daniela Cojocaru
,
Liliana Vereștiuc
,
Oana Cioancă
,
Ingrid-Andrada Vasilache
,
Ana-Maria Adam
,
Cornelia Mircea
,
Aurel Nechita
,
Valeriu Harabor
,
Bogdan Huzum
,
Anamaria Hărăbor
,
Monica Hăncianu
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.20944/preprints202311.1599.v1
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.20944/preprints202311.1599.v1
(1) Background: This study aimed to outline the antitumoral, antioxidant, and cytotoxic proprie-ties of various types of Perilla frutescens extracts obtained from the leaves of the species; (2) Methods: We determined total polyphenols, flavonoids and anthocyanins contents, as well as the in vitro antioxidant, antitumoral, and cytotoxic actions in 3 types of ethanolic extracts (E1, E2, E3) and in 3 types of ethanol: acetone extracts (A1, A2, A3) of Perilla frutescens according to standardized procedures; (3) Results: We found that Perilla frutescens ethanolic extracts had higher total phenol concentrations (p= 0.002). Flavonoids and anthocyanins concentrations were not statistically different between the two extracts. The iron chelating capacity, hydroxyl radical scavenging capacity, superoxide anion radical scavenging capacity, and lipoxygenase inhibition capacity showed a significant increase with higher concentrations of Perilla frutescens extracts, particularly the ethanolic extracts. Perillyl alcohol had greater cytotoxic capacity on MG-63 cell line and E1 extract showed similar significant cytotoxic effects on A431 cell line; (4) Conclusions: Both ethanolic and ethanol: acetone extracts from Perilla frutescens exhibited important antioxi-dant and antitumoral actions in vitro, which proportionally increased with concentration. The cytotoxic threshold determined in this study for various types of extracts could help determine the best dosage with the maximum antioxidant and antitumoral potential.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.20944/preprints202311.1599.v1
- https://www.preprints.org/manuscript/202311.1599/v1/download
- OA Status
- green
- References
- 31
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4389029390
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4389029390Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.20944/preprints202311.1599.v1Digital Object Identifier
- Title
-
Assessing the <em>In Vitro</em> Cytotoxicity, Antitumoral and Antioxidant Properties of Polyphenol‐rich <em>Perilla leaves </em>ExtractsWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-11-24Full publication date if available
- Authors
-
Gigi Adam, Florina-Daniela Cojocaru, Liliana Vereștiuc, Oana Cioancă, Ingrid-Andrada Vasilache, Ana-Maria Adam, Cornelia Mircea, Aurel Nechita, Valeriu Harabor, Bogdan Huzum, Anamaria Hărăbor, Monica HăncianuList of authors in order
- Landing page
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https://doi.org/10.20944/preprints202311.1599.v1Publisher landing page
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https://www.preprints.org/manuscript/202311.1599/v1/downloadDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.preprints.org/manuscript/202311.1599/v1/downloadDirect OA link when available
- Concepts
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Perilla frutescens, Chemistry, Polyphenol, Antioxidant, Perilla, Acetone, Cytotoxic T cell, In vitro, Pro-oxidant, Cytotoxicity, Biochemistry, Traditional medicine, Superoxide, Antioxidant capacity, Food science, Organic chemistry, Enzyme, Raw material, MedicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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31Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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