Assessing the Role of Past Depression in Patients with Mild Cognitive Impairment, with and without Biomarkers for Alzheimer’s Disease Article Swipe
Angela Golas
,
Patrick Salwierz
,
Tarek K. Rajji
,
Christopher R. Bowie
,
Meryl A. Butters
,
Corinne E. Fischer
,
Alastair J. Flint
,
Nathan Herrmann
,
Linda Mah
,
Benoit H. Mulsant
,
Bruce G. Pollock
,
Foad Taghdiri
,
Wei Wang
,
Maria Carmela Tartaglia
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3233/jad-221097
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3233/jad-221097
Major depressive disorder (MDD) is a risk factor for Alzheimer’s disease (AD). Cerebrovascular disease (CVD) is implicated in MDD and AD. Our study compared participants with AD positive and negative cerebrospinal fluid (CSF) biomarkers on neuropsychological performance, remitted MDD status, and CVD burden. Next, we compared AD-CSF biomarkers and white matter hyperintensities (WMH) burden among three groups: mild cognitive impairment (MCI) (n = 12), MCI with remitted MDD (MDD+MCI) (n = 12), and remitted MDD alone (MDD) (n = 7). Few participants (18%) with MCI+MDD exhibited AD(+) biomarkers. Nearly all participants had moderate-severe WMH. WMH may contribute to cognitive impairment or depression in MCI patients with AD(-) biomarkers.
Related Topics
Concepts
Major depressive disorder
Depression (economics)
Hyperintensity
Neuropsychology
Cognitive impairment
Psychology
Disease
Internal medicine
Biomarker
Oncology
Alzheimer's disease
Psychiatry
Cognition
Cerebrospinal fluid
Clinical psychology
Medicine
Magnetic resonance imaging
Chemistry
Biochemistry
Macroeconomics
Economics
Radiology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3233/jad-221097
- https://content.iospress.com:443/download/journal-of-alzheimers-disease/jad221097?id=journal-of-alzheimers-disease%2Fjad221097
- OA Status
- hybrid
- Cited By
- 5
- References
- 69
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4323832854
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4323832854Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3233/jad-221097Digital Object Identifier
- Title
-
Assessing the Role of Past Depression in Patients with Mild Cognitive Impairment, with and without Biomarkers for Alzheimer’s DiseaseWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-03-10Full publication date if available
- Authors
-
Angela Golas, Patrick Salwierz, Tarek K. Rajji, Christopher R. Bowie, Meryl A. Butters, Corinne E. Fischer, Alastair J. Flint, Nathan Herrmann, Linda Mah, Benoit H. Mulsant, Bruce G. Pollock, Foad Taghdiri, Wei Wang, Maria Carmela TartagliaList of authors in order
- Landing page
-
https://doi.org/10.3233/jad-221097Publisher landing page
- PDF URL
-
https://content.iospress.com:443/download/journal-of-alzheimers-disease/jad221097?id=journal-of-alzheimers-disease%2Fjad221097Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://content.iospress.com:443/download/journal-of-alzheimers-disease/jad221097?id=journal-of-alzheimers-disease%2Fjad221097Direct OA link when available
- Concepts
-
Major depressive disorder, Depression (economics), Hyperintensity, Neuropsychology, Cognitive impairment, Psychology, Disease, Internal medicine, Biomarker, Oncology, Alzheimer's disease, Psychiatry, Cognition, Cerebrospinal fluid, Clinical psychology, Medicine, Magnetic resonance imaging, Chemistry, Biochemistry, Macroeconomics, Economics, RadiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
5Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 3Per-year citation counts (last 5 years)
- References (count)
-
69Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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