Assessment of Inter-Reader Reliability of Fazekas Scoring on Magnetic Resonance Imaging of the Brain in Adult Patients with Sickle Cell Disease Article Swipe
Aoife M. Haughey
,
Roisin M. O’Cearbhaill
,
Stéphanie Forté
,
Joanna D. Schaafsma
,
Kevin H.M. Kuo
,
Igor Gomes Padilha
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/diagnostics15070857
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/diagnostics15070857
Background/Objectives: Cerebral white matter disease is a common finding in patients with sickle cell that has been linked to cognitive impairment. However, there is no standardized approach for quantification of the cerebral disease burden. The Fazekas score is widely used to quantify the burden of white matter disease in chronic small vessel disease. However, its utility in sickle cell disease, specifically the inter-rater variability, has not been established. Methods: A patient cohort was compiled for the purpose of a research ethics board (REB)-approved retrospective study of adult patients with sickle cell disease, each of whom underwent MRI/MRA between the years 2017 and 2019. A total of 90 such patients were captured. All MRI/MRA studies were performed on three Tesla MRIs. Two independent neuroradiologists assessed the axial FLAIR MRI brain sequence (see image 1) for each of the 90 patients, with the sole focus of assigning a Fazekas score (0–3) to each study as a means of quantifying the burden of ischemic white matter lesions. The neuroradiologists were blinded to the scoring assigned by their counterpart and to the clinical information. After the initial assessment was completed, studies with discrepant Fazekas scores were documented and discussed by both readers. A consensus Fazekas score was then assigned to each of these studies. Results: Cohen’s weighted kappa was used as a measure of agreement between readers. The expected agreement was 74.65%, with an observed agreement of 94.44% between readers, with a kappa of 0.7808. Conclusions: We conclude on the basis of our study that there is good inter-reader reliability of Fazekas scoring on axial FLAIR MRI brain sequence in patients with sickle cell disease. The Fazekas is a promising measure that could easily be integrated in systematic evaluation of cerebrovascular lesions of adults with sickle cell disease.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/diagnostics15070857
- https://www.mdpi.com/2075-4418/15/7/857/pdf?version=1743075082
- OA Status
- gold
- References
- 31
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408928446
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4408928446Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/diagnostics15070857Digital Object Identifier
- Title
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Assessment of Inter-Reader Reliability of Fazekas Scoring on Magnetic Resonance Imaging of the Brain in Adult Patients with Sickle Cell DiseaseWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
-
2025-03-27Full publication date if available
- Authors
-
Aoife M. Haughey, Roisin M. O’Cearbhaill, Stéphanie Forté, Joanna D. Schaafsma, Kevin H.M. Kuo, Igor Gomes PadilhaList of authors in order
- Landing page
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https://doi.org/10.3390/diagnostics15070857Publisher landing page
- PDF URL
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https://www.mdpi.com/2075-4418/15/7/857/pdf?version=1743075082Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2075-4418/15/7/857/pdf?version=1743075082Direct OA link when available
- Concepts
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Magnetic resonance imaging, Disease, Nuclear magnetic resonance, Medicine, Reliability (semiconductor), Neuroscience, Psychology, Internal medicine, Physics, Radiology, Power (physics), Quantum mechanicsTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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31Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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