ASSESSMENT OF OXIDATIVE STRESS AND ANTIOXIDANT STATUS IN TYPE 1 DIABETES MELLITUS Article Swipe
Fatimah Haitham Fathi
,
Jehan A. Mohammad
,
Ammar A. Y. Almulathanon
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.31482/mmsl.2023.015
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.31482/mmsl.2023.015
Increased oxidative stress appears to be a risk factor for insulin resistance, dyslipidemia, β-cell dysfunction, impaired glucose tolerance, and, eventually, diabetes mellitus.The majority of research shows that oxidative stress plays a role in the etiology of diabetes through changes in enzymatic systems, lipid peroxidation, decreased levels of vitamin C, and reduced glutathione metabolism.Objectives: the study was conducted to evaluate biomarkers of oxidative stress such as serum malondialdehyde (MDA), myeloperoxidase (MPO), catalase (CAT), vitamins (C, E), nitric oxide (NO), reduced glutathione (GSH) levels and a lipid profile in newly diagnosed type I diabetics (IDDM).Methods: Patients are selected by simple randomization after professional diagnosis based on clinical examination and laboratory tests in a case-control study.This study included 24 newly diagnosed type I diabetics and 20 as a control group.Results: Newly diagnosed IDDM patients showed significantly higher MDA, MPO, TC, LDL, TC, TG, and AIP than the control group.The diabetic group also showed a significant decrease in CAT, GSH, HDL, NO and vitamins (E and C) when compared to healthy subjects.Conclusion: This study demonstrated that patients with type 1 diabetes have a disturbance in oxidant/antioxidant status and lipid profile.
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- article
- Language
- en
- Landing Page
- https://doi.org/10.31482/mmsl.2023.015
- http://mmsl.cz/doi/10.31482/mmsl.2023.015.pdf
- OA Status
- diamond
- References
- 40
- Related Works
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- OpenAlex ID
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https://doi.org/10.31482/mmsl.2023.015Digital Object Identifier
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ASSESSMENT OF OXIDATIVE STRESS AND ANTIOXIDANT STATUS IN TYPE 1 DIABETES MELLITUSWork title
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articleOpenAlex work type
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enPrimary language
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2023Year of publication
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2023-08-31Full publication date if available
- Authors
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Fatimah Haitham Fathi, Jehan A. Mohammad, Ammar A. Y. AlmulathanonList of authors in order
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https://doi.org/10.31482/mmsl.2023.015Publisher landing page
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https://mmsl.cz/doi/10.31482/mmsl.2023.015.pdfDirect link to full text PDF
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://mmsl.cz/doi/10.31482/mmsl.2023.015.pdfDirect OA link when available
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Oxidative stress, Type 2 Diabetes Mellitus, Antioxidant, Diabetes mellitus, Type 2 diabetes, Internal medicine, Medicine, Endocrinology, Chemistry, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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| abstract_inverted_index.status | 182 |
| abstract_inverted_index.stress | 2, 28, 62 |
| abstract_inverted_index.appears | 3 |
| abstract_inverted_index.changes | 38 |
| abstract_inverted_index.control | 125, 144 |
| abstract_inverted_index.glucose | 16 |
| abstract_inverted_index.healthy | 166 |
| abstract_inverted_index.insulin | 10 |
| abstract_inverted_index.profile | 85 |
| abstract_inverted_index.reduced | 50, 78 |
| abstract_inverted_index.through | 37 |
| abstract_inverted_index.vitamin | 47 |
| abstract_inverted_index.β-cell | 13 |
| abstract_inverted_index.Patients | 93 |
| abstract_inverted_index.catalase | 70 |
| abstract_inverted_index.clinical | 104 |
| abstract_inverted_index.compared | 164 |
| abstract_inverted_index.decrease | 152 |
| abstract_inverted_index.diabetes | 20, 36, 176 |
| abstract_inverted_index.diabetic | 146 |
| abstract_inverted_index.etiology | 34 |
| abstract_inverted_index.evaluate | 58 |
| abstract_inverted_index.impaired | 15 |
| abstract_inverted_index.included | 114 |
| abstract_inverted_index.majority | 22 |
| abstract_inverted_index.patients | 130, 172 |
| abstract_inverted_index.profile. | 185 |
| abstract_inverted_index.research | 24 |
| abstract_inverted_index.selected | 95 |
| abstract_inverted_index.systems, | 41 |
| abstract_inverted_index.vitamins | 72, 159 |
| abstract_inverted_index.Increased | 0 |
| abstract_inverted_index.conducted | 56 |
| abstract_inverted_index.decreased | 44 |
| abstract_inverted_index.diabetics | 91, 120 |
| abstract_inverted_index.diagnosed | 88, 117, 128 |
| abstract_inverted_index.diagnosis | 101 |
| abstract_inverted_index.enzymatic | 40 |
| abstract_inverted_index.group.The | 145 |
| abstract_inverted_index.oxidative | 1, 27, 61 |
| abstract_inverted_index.biomarkers | 59 |
| abstract_inverted_index.laboratory | 107 |
| abstract_inverted_index.study.This | 112 |
| abstract_inverted_index.tolerance, | 17 |
| abstract_inverted_index.disturbance | 179 |
| abstract_inverted_index.eventually, | 19 |
| abstract_inverted_index.examination | 105 |
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| abstract_inverted_index.resistance, | 11 |
| abstract_inverted_index.significant | 151 |
| abstract_inverted_index.case-control | 111 |
| abstract_inverted_index.demonstrated | 170 |
| abstract_inverted_index.dysfunction, | 14 |
| abstract_inverted_index.mellitus.The | 21 |
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| abstract_inverted_index.dyslipidemia, | 12 |
| abstract_inverted_index.peroxidation, | 43 |
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| abstract_inverted_index.(IDDM).Methods: | 92 |
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| abstract_inverted_index.myeloperoxidase | 68 |
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| abstract_inverted_index.metabolism.Objectives: | 52 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 3 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/2 |
| sustainable_development_goals[0].score | 0.5 |
| sustainable_development_goals[0].display_name | Zero hunger |
| citation_normalized_percentile.value | 0.2008088 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |