Assessment of Quality of Life, Adherence, and Stigmatization among People Receiving Anti-Tuberculosis Medications in Three Tertiary Hospitals in Sierra Leone: A Cross- Sectional Study Article Swipe
Michael Lahai
,
Sally-Mattu Conteh
,
Ahmed Vandy
,
Onome T. Abiri
,
Brian J. Thompson
,
Mohamed Bawoh
,
Alvin Turay
,
Peter James
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-6187729/v1
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-6187729/v1
Background Tuberculosis (TB) remains a significant public health concern, particularly in resource-limited settings, where the burden of TB is compounded by socioeconomic challenges and stigmatization. This study assessed the quality of life, treatment adherence, and stigmatization among patients receiving anti-TB medications in three tertiary hospitals in Sierra Leone. Method A cross-sectional study of 384 patients at Connaught, Lakka, and Kenema government hospitals was conducted between May to July 2021. Data was collected using a structured pre-tested questionnaire, consisting of the Morisky adherence scale, WHO Quality of Life tool, and Stigma Scale for Chronic Illnesses to measure adherence, quality of life and stigma respectively. Data was analyzed using descriptive and inferential statistics using the Statistical Package for Social Sciences 16. Associations between independent variables and quality of life were determined using an independent sample T-test and ANOVA. Post hoc analysis was further conducted for variables that were significant using backward multivariate linear regression. Results More than half of the patients were male with a mean age of 33.92 years. The overall adherence rate among the patients in our study was 96.9%. The social relationship domain (64.65, SD = 15.6) recorded the highest Quality of Life score, while the environmental health domain (58.18, SD = 13.5) was the lowest. The result of the backward multivariate linear regression revealed patient age to be statistically significant with the physical Health (P-value = 0.000), psychological Health (P-value = 0.017) and environmental health domains (P-value = 0.005). Having kids, Marital status, religion, and family economic situation were also found to be statistically significant with various other individual quality of life domains. The stigma indicators in this study were low with 24 (6.3%) and 50 (13.0%) of the patients reporting rejection from spouse and other family members respectively. Conclusion Despite the study revealed an encouraging adherence rate, gaps in the psychological and environmental quality of life, along with stigma, require urgent public health action. Enhancing family support, reducing economic burdens, and combating stigma through public sensitization is crucial for better outcomes for TB patients.
Related Topics
Concepts
Medicine
Quality of life (healthcare)
Cross-sectional study
Bayesian multivariate linear regression
Tuberculosis
Sierra leone
Socioeconomic status
Stigma (botany)
Public health
Multivariate analysis
Descriptive statistics
Social determinants of health
Gerontology
Environmental health
Regression analysis
Internal medicine
Psychiatry
Nursing
Population
Development economics
Statistics
Mathematics
Machine learning
Computer science
Pathology
Economics
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-6187729/v1
- https://www.researchsquare.com/article/rs-6187729/latest.pdf
- OA Status
- gold
- References
- 10
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409738197
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4409738197Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21203/rs.3.rs-6187729/v1Digital Object Identifier
- Title
-
Assessment of Quality of Life, Adherence, and Stigmatization among People Receiving Anti-Tuberculosis Medications in Three Tertiary Hospitals in Sierra Leone: A Cross- Sectional StudyWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-04-24Full publication date if available
- Authors
-
Michael Lahai, Sally-Mattu Conteh, Ahmed Vandy, Onome T. Abiri, Brian J. Thompson, Mohamed Bawoh, Alvin Turay, Peter JamesList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-6187729/v1Publisher landing page
- PDF URL
-
https://www.researchsquare.com/article/rs-6187729/latest.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.researchsquare.com/article/rs-6187729/latest.pdfDirect OA link when available
- Concepts
-
Medicine, Quality of life (healthcare), Cross-sectional study, Bayesian multivariate linear regression, Tuberculosis, Sierra leone, Socioeconomic status, Stigma (botany), Public health, Multivariate analysis, Descriptive statistics, Social determinants of health, Gerontology, Environmental health, Regression analysis, Internal medicine, Psychiatry, Nursing, Population, Development economics, Statistics, Mathematics, Machine learning, Computer science, Pathology, EconomicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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10Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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