Assessment of Quercetin Antiemetic Properties: In Vivo and In Silico Investigations on Receptor Binding Affinity and Synergistic Effects Article Swipe
Raihan Chowdhury
,
Md. Shimul Bhuia
,
Asraful Islam Rakib
,
Md. Rubel Hasan
,
Henrique Douglas Melo Coutinho
,
Isaac Moura Araújo
,
Irwin Rose Alencar de Menezes
,
Muhammad Torequl Islam
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.20944/preprints202311.1044.v1
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.20944/preprints202311.1044.v1
Quercetin (QUA), a flavonoid compound, is ubiquitously found in plants and has demonstrated a diverse range of biological activities. The primary objective of the present study is to assess the potential antiemetic properties of QUA using an in vivo and in silico approach. In this experiment, emesis was induced in 4-day-old chicks by orally administering copper sulfate pentahydrate (CuSO4.5H2O) at a dose of 50 mg/kg (orally). Domperidone (6 mg/kg), ondansetron (5 mg/kg), and hyoscine (21 mg/kg) were treated as positive controls (PCs), and distilled water was employed as a negative control (NC). QUA was administered orally at two distinct doses (25 and 50 mg/kg). Additionally, QUA (50 mg/kg) and PCs were administered separately or in combination to assess their antagonistic or synergistic effects on the chicks. The binding affinity of QUA and referral ligands towards 5HT3, D2, D3, and M1–M5 receptors was estimated, and ligand-receptor interactions were visualized through various computational tools. In vivo findings indicate that QUA (25 and 50 mg/kg) has a significant effect on reducing the number of retches (16.50 ± 4.65 and 10.00 ± 4.19 times) and increasing the chick latency period (59.25 ± 4.75 and 94.25 ± 4.01 seconds), respectively. Additionally, QUA (50 mg/kg) in combination with domperidone and ondansetron exhibited superior antiemetic effects, reducing the number of retches and increasing the onset of emesis-inducing time. Furthermore, it is worth noting that QUA demonstrated the strongest binding affinity towards the D2 receptor with a value of -9.7 kcal/mol through the formation of hydrogen and hydrophobic bonds. In summary, the study found that QUA exhibited antiemetic activity in chicks, potentially by interacting with the D2 receptor pathway.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.20944/preprints202311.1044.v1
- https://www.preprints.org/manuscript/202311.1044/v1/download
- OA Status
- green
- Cited By
- 11
- References
- 79
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4388774403
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4388774403Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.20944/preprints202311.1044.v1Digital Object Identifier
- Title
-
Assessment of Quercetin Antiemetic Properties: In Vivo and In Silico Investigations on Receptor Binding Affinity and Synergistic EffectsWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-11-16Full publication date if available
- Authors
-
Raihan Chowdhury, Md. Shimul Bhuia, Asraful Islam Rakib, Md. Rubel Hasan, Henrique Douglas Melo Coutinho, Isaac Moura Araújo, Irwin Rose Alencar de Menezes, Muhammad Torequl IslamList of authors in order
- Landing page
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https://doi.org/10.20944/preprints202311.1044.v1Publisher landing page
- PDF URL
-
https://www.preprints.org/manuscript/202311.1044/v1/downloadDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.preprints.org/manuscript/202311.1044/v1/downloadDirect OA link when available
- Concepts
-
In vivo, Pharmacology, Domperidone, Cimetidine, Antiemetic, Quercetin, Chemistry, Medicine, Biology, Internal medicine, Biochemistry, Biotechnology, Chemotherapy, Antioxidant, DopamineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
11Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 8, 2024: 2, 2023: 1Per-year citation counts (last 5 years)
- References (count)
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79Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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