Assessment of social cognition in patients with amyotrophic lateral sclerosis: protocol for a cross-sectional comparative study at Angers University Hospital Article Swipe
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· 2025
· Open Access
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· DOI: https://doi.org/10.1136/bmjopen-2024-097543
Introduction Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder primarily affecting motor neurons. In addition to motor impairments, ALS frequently involves cognitive and behavioural disturbances, including deficits in social cognition, which can impact interpersonal interactions and decision-making. Despite increasing recognition of these impairments, existing assessment tools often rely on static stimuli, limiting their ecological validity. Methods and analysis This cross-sectional, single-centre study aims to assess social cognition abilities in patients with ALS compared with healthy controls using a combination of dynamic and static neuropsychological tools. The primary outcome measure will be performance on the Movie for the Assessment of Social Cognition, an ecologically valid test evaluating theory of mind. Secondary outcomes will include emotion recognition (static and dynamic tasks: Ekman Faces and French Emotion Evaluation Test), mood assessments (Hospital Anxiety and Depression Scale) and clinical variables such as disease severity (ALS Functional Rating Scale-Revised), cognitive function (Edinburgh Cognitive and Behavioural Screen, Mini–Mental State Examination) and disease staging (King’s ALS Clinical Staging System). A total of 74 participants (37 patients with ALS and 37 matched healthy controls) will be recruited. Group differences will be analysed using analysis of variance, while regression models will explore associations between social cognitive deficits and clinical markers of ALS progression. Ethics and dissemination This study has been approved by the French Ethics Committee (CPP) Ouest I under reference 2020-A01213-36. Data collection and processing comply with French and European data protection regulations (GDPR, Loi Informatique et Libertés). Findings will be disseminated through peer-reviewed journals and scientific conferences and will contribute to improving neuropsychological assessment methods for ALS. Trial registration number NCT04406675 .
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1136/bmjopen-2024-097543
- OA Status
- gold
- References
- 81
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4412048154
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4412048154Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1136/bmjopen-2024-097543Digital Object Identifier
- Title
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Assessment of social cognition in patients with amyotrophic lateral sclerosis: protocol for a cross-sectional comparative study at Angers University HospitalWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-07-01Full publication date if available
- Authors
-
J. Baets, Jérémy Besnard, Julien Cassereau, Etienne Emmelin, Philippe AllainList of authors in order
- Landing page
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https://doi.org/10.1136/bmjopen-2024-097543Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1136/bmjopen-2024-097543Direct OA link when available
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Cognition, Medicine, Neuropsychology, Social cognition, Clinical psychology, Mood, Amyotrophic lateral sclerosis, Apathy, Anxiety, Psychiatry, Psychology, Disease, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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81Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.2020-A01213-36. | 223 |
| abstract_inverted_index.Scale-Revised), | 144 |
| abstract_inverted_index.cross-sectional, | 60 |
| abstract_inverted_index.decision-making. | 37 |
| abstract_inverted_index.neurodegenerative | 8 |
| abstract_inverted_index.neuropsychological | 84, 256 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 5 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/16 |
| sustainable_development_goals[0].score | 0.5899999737739563 |
| sustainable_development_goals[0].display_name | Peace, Justice and strong institutions |
| citation_normalized_percentile.value | 0.38642576 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |