Associated factors for the development of acute coronary syndrome or stable coronary artery disease Article Swipe
Osamu Sasaki
,
Toshihiko Nishioka
,
Takafumi Inokuchi
,
Hirotaka Takatori
,
T Nakata
,
Yoshihiro Nakamura
,
Takeshi Nakato
,
Shunichi Tsukada
,
Ryutaro Yamaguchi
,
Ami Isshiki
,
Kentaro Toyama
,
Toshiyuki Ando
,
Yoshiro Inoue
,
Tetsuo Kamiyama
,
Masato Kirimura
,
Hiroyuki Ito
,
Nobuo Yoshimoto
,
Hideki Sasaki
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.7793/jcoron.22.16-00006
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.7793/jcoron.22.16-00006
【目的】急性冠症候群 (ACS) または安定冠動脈疾患 (SCAD) 患者の背景ならびに経皮的冠動脈インターベンション (PCI) 対象責任病変の特徴を比較することで，ACSならびにSCAD発症病態の差異に関連する因子を探索すること.【方法】血管内超音波 (IVUS) ガイド下でPCIを行った連続 513名 (ACS 392名，SCAD 121名) を対象とし，背景因子，冠危険因子，内服薬，冠動脈造影所見について調査し，冠動脈責任病変のプラーク面積，冠動脈プラーク組成をVirtual Histology IVUS (VH-IVUS) を用いて解析した．これらの変数をACS群とSCAD群間で比較したのち，ACSを目的変数とした多重ロジスティック回帰分析を行った.【結果】HDLコレステロール (high density lipoprotein cholesterol: HDL-C) はACS群でSCAD群より低く (43.5 ± 13.1 mg/dl vs 48.1 ± 18.1 mg/dl, p=0.002), スタチン, アンジオテンシン変換酵素阻害薬 (ACEI) またはアンジオテンシンII受容体拮抗薬 (ARB) およびβ遮断薬内服が低率であった (12.8% vs 36.4%, p<0.001; 22.7% vs 33.9%, p=0.013; 7.9% vs 14.9%, p=0.022). VH-IVUS で解析したプラーク組成 (%) に差はなく, プラーク面積およびリモデリングインデックスはACS群でSCAD群より大であった (14.7 ± 5.1 mm2 vs 12.0 ± 4.5 mm2, p<0.001; 1.15 ± 0.23 vs 1.09 ± 0.24, p=0.012). ACSを目的変数とした多重ロジスティック回帰分析を行ったところ, HDL-C (オッズ比: OR=0.965, p=0.002), スタチン内服 (OR=0.261, p<0.001), リモデリングインデックス (OR=3.093, p=0.044) がACS発症に関連する因子となった.【結論】ACSまたはSCAD発症の差異に関連する因子はHDL-C, スタチン内服および冠動脈リモデリングであった．
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.7793/jcoron.22.16-00006
- https://www.jstage.jst.go.jp/article/jcoron/22/3/22_22.16-00006/_pdf
- OA Status
- diamond
- References
- 34
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2511505118
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2511505118Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.7793/jcoron.22.16-00006Digital Object Identifier
- Title
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Associated factors for the development of acute coronary syndrome or stable coronary artery diseaseWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2016Year of publication
- Publication date
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2016-01-01Full publication date if available
- Authors
-
Osamu Sasaki, Toshihiko Nishioka, Takafumi Inokuchi, Hirotaka Takatori, T Nakata, Yoshihiro Nakamura, Takeshi Nakato, Shunichi Tsukada, Ryutaro Yamaguchi, Ami Isshiki, Kentaro Toyama, Toshiyuki Ando, Yoshiro Inoue, Tetsuo Kamiyama, Masato Kirimura, Hiroyuki Ito, Nobuo Yoshimoto, Hideki SasakiList of authors in order
- Landing page
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https://doi.org/10.7793/jcoron.22.16-00006Publisher landing page
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https://www.jstage.jst.go.jp/article/jcoron/22/3/22_22.16-00006/_pdfDirect link to full text PDF
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://www.jstage.jst.go.jp/article/jcoron/22/3/22_22.16-00006/_pdfDirect OA link when available
- Concepts
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Scad, Acute coronary syndrome, Internal medicine, Cardiology, Medicine, Conventional PCI, Coronary artery disease, Myocardial infarctionTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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34Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.0.24, | 73 |
| abstract_inverted_index.22.7% | 44 |
| abstract_inverted_index.HDL-C | 76 |
| abstract_inverted_index.mg/dl | 27 |
| abstract_inverted_index.(12.8% | 40 |
| abstract_inverted_index.(ACEI) | 36 |
| abstract_inverted_index.(IVUS) | 7 |
| abstract_inverted_index.(SCAD) | 3 |
| abstract_inverted_index.14.9%, | 50 |
| abstract_inverted_index.33.9%, | 46 |
| abstract_inverted_index.36.4%, | 42 |
| abstract_inverted_index.513名 | 9 |
| abstract_inverted_index.HDL-C) | 22 |
| abstract_inverted_index.mg/dl, | 32 |
| abstract_inverted_index.121名) | 12 |
| abstract_inverted_index.VH-IVUS | 52 |
| abstract_inverted_index.density | 19 |
| abstract_inverted_index.p<0.001; | 43, 66 |
| abstract_inverted_index.p=0.013; | 47 |
| abstract_inverted_index.p=0.044) | 85 |
| abstract_inverted_index.(VH-IVUS) | 16 |
| abstract_inverted_index.Histology | 14 |
| abstract_inverted_index.OR=0.965, | 78 |
| abstract_inverted_index.p<0.001), | 82 |
| abstract_inverted_index.p=0.002), | 33, 79 |
| abstract_inverted_index.p=0.012). | 74 |
| abstract_inverted_index.p=0.022). | 51 |
| abstract_inverted_index.(OR=0.261, | 81 |
| abstract_inverted_index.(OR=3.093, | 84 |
| abstract_inverted_index.lipoprotein | 20 |
| abstract_inverted_index.cholesterol: | 21 |
| abstract_inverted_index.392名，SCAD | 11 |
| abstract_inverted_index.スタチン, | 34 |
| abstract_inverted_index.(オッズ比: | 77 |
| abstract_inverted_index.に差はなく, | 55 |
| abstract_inverted_index.スタチン内服 | 80 |
| abstract_inverted_index.【目的】急性冠症候群 | 0 |
| abstract_inverted_index.または安定冠動脈疾患 | 2 |
| abstract_inverted_index.はACS群でSCAD群より低く | 23 |
| abstract_inverted_index.で解析したプラーク組成 | 53 |
| abstract_inverted_index.ガイド下でPCIを行った連続 | 8 |
| abstract_inverted_index.リモデリングインデックス | 83 |
| abstract_inverted_index.アンジオテンシン変換酵素阻害薬 | 35 |
| abstract_inverted_index.およびβ遮断薬内服が低率であった | 39 |
| abstract_inverted_index.またはアンジオテンシンII受容体拮抗薬 | 37 |
| abstract_inverted_index.スタチン内服および冠動脈リモデリングであった． | 87 |
| abstract_inverted_index.患者の背景ならびに経皮的冠動脈インターベンション | 4 |
| abstract_inverted_index.ACSを目的変数とした多重ロジスティック回帰分析を行ったところ, | 75 |
| abstract_inverted_index.プラーク面積およびリモデリングインデックスはACS群でSCAD群より大であった | 56 |
| abstract_inverted_index.がACS発症に関連する因子となった.【結論】ACSまたはSCAD発症の差異に関連する因子はHDL-C, | 86 |
| abstract_inverted_index.対象責任病変の特徴を比較することで，ACSならびにSCAD発症病態の差異に関連する因子を探索すること.【方法】血管内超音波 | 6 |
| abstract_inverted_index.を対象とし，背景因子，冠危険因子，内服薬，冠動脈造影所見について調査し，冠動脈責任病変のプラーク面積，冠動脈プラーク組成をVirtual | 13 |
| abstract_inverted_index.を用いて解析した．これらの変数をACS群とSCAD群間で比較したのち，ACSを目的変数とした多重ロジスティック回帰分析を行った.【結果】HDLコレステロール | 17 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 18 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.75 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.13207605 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |