Association Between CACNA1C Polymorphisms and Insomnia in a Chinese Han Population: A Case-Control Population-Based Analysis Article Swipe
Liucui Chen
,
Huaxin Li
,
Haijun Yuan
,
Wei Gao
,
Feng Liu
,
Bing Ma
,
Yingmei Ding
,
Xiaofen Liu
,
Mei Yuan
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-651151/v1
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-651151/v1
A limited number of genome-wide association studies (GWAS) have shown that CACNA1C is a potential candidate gene for insomnia. The present study sought to investigate the association of CACNA1C gene polymorphisms and insomnia in a Chinese Han population. Twenty-one single nucleotide polymorphisms (SNPs) in the CACNA1C were genotyped by using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) with a Sequenom MassARRAY system in 205 patients with insomnia and 154 healthy controls. Data from all participants were systematically collected. Association of the polymorphisms with insomnia was evaluated by statistical analysis. Linkage disequilibrium (LD) and haplotype analysis were performed with Haploview v4.2 software. After adjustment for multiple comparisons and gender, age, body mass index (BMI), hypertension and glycated hemoglobin (HbA1c), only the rs2302729 in the recessive model (adjusted odds ratio [AOR]= 0.414, 95%CI= 0.220-0.771, P= 0.004) related to insomnia achieved significance by the false discovery rate (FDR) Benjamini and Hochberg (BH) criterion. The haplotypes rs2302729-rs1051375, CA and TG were significantly associated with insomnia (P<0.05). Our findings contributed important evidence for the confirming of CACNA1C as a susceptibility gene for insomnia in the samples of Chinese Han population.
Related Topics
Concepts
Association (psychology)
Insomnia
China
Chinese population
Population
Han chinese
Medicine
Demography
Genetics
Geography
Psychology
Psychiatry
Biology
Environmental health
Single-nucleotide polymorphism
Sociology
Gene
Genotype
Psychotherapist
Archaeology
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-651151/v1
- https://www.researchsquare.com/article/rs-651151/latest.pdf
- OA Status
- gold
- Cited By
- 2
- References
- 37
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3176604107
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3176604107Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21203/rs.3.rs-651151/v1Digital Object Identifier
- Title
-
Association Between CACNA1C Polymorphisms and Insomnia in a Chinese Han Population: A Case-Control Population-Based AnalysisWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-06-28Full publication date if available
- Authors
-
Liucui Chen, Huaxin Li, Haijun Yuan, Wei Gao, Feng Liu, Bing Ma, Yingmei Ding, Xiaofen Liu, Mei YuanList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-651151/v1Publisher landing page
- PDF URL
-
https://www.researchsquare.com/article/rs-651151/latest.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.researchsquare.com/article/rs-651151/latest.pdfDirect OA link when available
- Concepts
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Association (psychology), Insomnia, China, Chinese population, Population, Han chinese, Medicine, Demography, Genetics, Geography, Psychology, Psychiatry, Biology, Environmental health, Single-nucleotide polymorphism, Sociology, Gene, Genotype, Psychotherapist, ArchaeologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
- Citations by year (recent)
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2023: 2Per-year citation counts (last 5 years)
- References (count)
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37Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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