Association between Cerebrospinal Fluid and Serum Biomarker Levels and Diagnosis, Injury Severity, and Short-Term Outcomes in Patients with Acute Traumatic Spinal Cord Injury Article Swipe
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· 2023
· Open Access
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· DOI: https://doi.org/10.3390/diagnostics13101814
Acute traumatic spinal cord injury (SCI) is recognized as a global problem that can lead to a range of acute and secondary complications impacting morbidity and mortality. There is still a lack of reliable diagnostic and prognostic biomarkers in patients with SCI that could help guide clinical care and identify novel therapeutic targets for future drug discovery. The aim of this prospective controlled study was to determine the cerebral spinal fluid (CSF) and serum profiles of 10 biomarkers as indicators of SCI diagnosis, severity, and prognosis to aid in assessing appropriate treatment modalities. CSF and serum samples of 15 SCI and ten healthy participants were included in the study. The neurological assessments were scored on admission and at discharge from the hospital using the American Spinal Injury Association Impairment Score (AIS) grades. The CSF and serum concentrations of SBDP150, S100B, GFAP, NF-L, UCHL-1, Tau, and IL-6 were significantly higher in SCI patients when compared with the control group. The CSF GBDP 38/44K, UCHL-L1, S100B, GFAP, and Tau levels were significantly higher in the AIS A patients. This study demonstrated a strong correlation between biomarker levels in the diagnosis and injury severity of SCI but no association with short-term outcomes. Future prospective controlled studies need to be done to support the results of this study.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/diagnostics13101814
- https://www.mdpi.com/2075-4418/13/10/1814/pdf?version=1684749575
- OA Status
- gold
- Cited By
- 7
- References
- 59
- Related Works
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- OpenAlex ID
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4377289449Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/diagnostics13101814Digital Object Identifier
- Title
-
Association between Cerebrospinal Fluid and Serum Biomarker Levels and Diagnosis, Injury Severity, and Short-Term Outcomes in Patients with Acute Traumatic Spinal Cord InjuryWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-05-22Full publication date if available
- Authors
-
Zhihui Yang, Seza Apilioğulları, Yueqiang Fu, Ayah Istanbouli, Sehajpreet Kaur, Iktej Singh Jabbal, Ahmed Moghieb, Zoha Irfan, Robert Logan Patterson, Milin Kurup, Lindsey Morrow, Michael Cohn, Zuo‐Feng Zhang, Jiepei Zhu, Ronald L. Hayes, Helen M. Bramlett, M. Ross Bullock, W. Dalton Dietrich, Michael Y. Wang, Firas Kobeissy, Kevin WangList of authors in order
- Landing page
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https://doi.org/10.3390/diagnostics13101814Publisher landing page
- PDF URL
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https://www.mdpi.com/2075-4418/13/10/1814/pdf?version=1684749575Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2075-4418/13/10/1814/pdf?version=1684749575Direct OA link when available
- Concepts
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Medicine, Biomarker, Traumatic brain injury, Cerebrospinal fluid, Prospective cohort study, Spinal cord injury, Internal medicine, Anesthesia, Spinal cord, Chemistry, Biochemistry, PsychiatryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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7Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 1, 2023: 3Per-year citation counts (last 5 years)
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59Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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