Association between diverticular disease and colorectal cancer: a bidirectional mendelian randomization study Article Swipe
Y. Zhang
,
Han Zhang
,
Jinghan Zhu
,
Yazhou He
,
Peng Wang
,
Doudou Li
,
Xiaozhuan Liu
,
Wen Jin
,
Junxi Zhang
,
Chuan Xu
,
Zengli Yu
,
Xin Zhao
,
Lingling Cui
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1186/s12885-023-10606-x
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1186/s12885-023-10606-x
Background: Diverticular disease has been inconsistently associated with colorectal cancer risk. We conducted a bidirectional Mendelian randomization study to assess this association. Methods: Forty-three and seventy single-nucleotide polymorphisms associated with diverticular disease and colorectal cancer at the genome-wide significance level ( p < 5 × 10 − 8 ) were selected as instrumental variables from large-scale genome-wide association studies of European descent, respectively. Summary-level data for colon cancer, rectum cancer, and colorectal cancer were obtained from genome-wide association analyses of the FinnGen consortium and the UK Biobank study. Summary-level data for diverticular disease was derived from a genome-wide association study conducted in the UK Biobank population. The random effect inverse-variance weighted Mendelian randomization approach was used as the primary method and MR-Egger, weighted-median, and MR-PRESSO approaches were conducted as sensitivity analyses. Results: Genetically determined diverticular disease was associated with a higher risk of colorectal cancer (beta = 0.441, 95%CI: 0.081–0.801, P = 0.016) in the FinnGen population, but the association was not found in the UK Biobank (beta = 0.208, 95%CI: -0.291,0.532, P = 0.207). The positive association remained consistent direction in the three sensitivity analyses. In the stratified analysis in the FinnGen consortium, an association was found to exist between genetically predicted diverticular disease and colon cancer (beta = 0.489, 95%CI: 0.020–0.959, P = 0.041), rather than rectum cancer (beta = 0.328, 95%CI: -0.119-0.775, P = 0.151). Besides, we found a slight association between colorectal cancer and diverticular disease (beta = 0.007, 95%CI: 0.004–0.010, P < 0.001) when using colorectal cancer as exposome and diverticular disease as outcome. However, there is a large sample overlap in this step of analysis. Conclusion: This Mendelian randomization study suggests that diverticular disease may be a possible risk factor for colorectal cancer and colon cancer rather than rectum cancer in the FinnGen population.
Related Topics
Concepts
Mendelian randomization
Medicine
Diverticular disease
Colorectal cancer
Internal medicine
Population
Genome-wide association study
Cancer
Single-nucleotide polymorphism
Surgical oncology
Oncology
Genetics
Biology
Genotype
Gene
Genetic variants
Environmental health
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1186/s12885-023-10606-x
- https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-023-10606-x
- OA Status
- gold
- Cited By
- 10
- References
- 37
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4319982193
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4319982193Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1186/s12885-023-10606-xDigital Object Identifier
- Title
-
Association between diverticular disease and colorectal cancer: a bidirectional mendelian randomization studyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-02-10Full publication date if available
- Authors
-
Y. Zhang, Han Zhang, Jinghan Zhu, Yazhou He, Peng Wang, Doudou Li, Xiaozhuan Liu, Wen Jin, Junxi Zhang, Chuan Xu, Zengli Yu, Xin Zhao, Lingling CuiList of authors in order
- Landing page
-
https://doi.org/10.1186/s12885-023-10606-xPublisher landing page
- PDF URL
-
https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-023-10606-xDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-023-10606-xDirect OA link when available
- Concepts
-
Mendelian randomization, Medicine, Diverticular disease, Colorectal cancer, Internal medicine, Population, Genome-wide association study, Cancer, Single-nucleotide polymorphism, Surgical oncology, Oncology, Genetics, Biology, Genotype, Gene, Genetic variants, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
10Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 7, 2023: 1Per-year citation counts (last 5 years)
- References (count)
-
37Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.obtained | 75 |
| abstract_inverted_index.outcome. | 259 |
| abstract_inverted_index.positive | 177 |
| abstract_inverted_index.possible | 284 |
| abstract_inverted_index.remained | 179 |
| abstract_inverted_index.selected | 51 |
| abstract_inverted_index.suggests | 277 |
| abstract_inverted_index.weighted | 111 |
| abstract_inverted_index.MR-Egger, | 122 |
| abstract_inverted_index.MR-PRESSO | 125 |
| abstract_inverted_index.Mendelian | 16, 112, 274 |
| abstract_inverted_index.analyses. | 131, 186 |
| abstract_inverted_index.analysis. | 271 |
| abstract_inverted_index.conducted | 13, 101, 128 |
| abstract_inverted_index.direction | 181 |
| abstract_inverted_index.predicted | 203 |
| abstract_inverted_index.variables | 54 |
| abstract_inverted_index.approaches | 126 |
| abstract_inverted_index.associated | 7, 29, 138 |
| abstract_inverted_index.colorectal | 9, 34, 72, 144, 236, 251, 288 |
| abstract_inverted_index.consistent | 180 |
| abstract_inverted_index.consortium | 83 |
| abstract_inverted_index.determined | 134 |
| abstract_inverted_index.stratified | 189 |
| abstract_inverted_index.Background: | 1 |
| abstract_inverted_index.Conclusion: | 272 |
| abstract_inverted_index.Forty-three | 24 |
| abstract_inverted_index.Genetically | 133 |
| abstract_inverted_index.association | 58, 78, 99, 160, 178, 196, 234 |
| abstract_inverted_index.consortium, | 194 |
| abstract_inverted_index.genetically | 202 |
| abstract_inverted_index.genome-wide | 38, 57, 77, 98 |
| abstract_inverted_index.large-scale | 56 |
| abstract_inverted_index.population, | 157 |
| abstract_inverted_index.population. | 106, 300 |
| abstract_inverted_index.sensitivity | 130, 185 |
| abstract_inverted_index.Diverticular | 2 |
| abstract_inverted_index.association. | 22 |
| abstract_inverted_index.diverticular | 31, 92, 135, 204, 239, 256, 279 |
| abstract_inverted_index.instrumental | 53 |
| abstract_inverted_index.significance | 39 |
| abstract_inverted_index.-0.119-0.775, | 225 |
| abstract_inverted_index.-0.291,0.532, | 172 |
| abstract_inverted_index.Summary-level | 64, 89 |
| abstract_inverted_index.bidirectional | 15 |
| abstract_inverted_index.polymorphisms | 28 |
| abstract_inverted_index.randomization | 17, 113, 275 |
| abstract_inverted_index.respectively. | 63 |
| abstract_inverted_index.0.004–0.010, | 245 |
| abstract_inverted_index.0.020–0.959, | 213 |
| abstract_inverted_index.0.081–0.801, | 150 |
| abstract_inverted_index.inconsistently | 6 |
| abstract_inverted_index.inverse-variance | 110 |
| abstract_inverted_index.weighted-median, | 123 |
| abstract_inverted_index.single-nucleotide | 27 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 13 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7099999785423279 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.93211755 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |