Association between left ventricular strain and fibrosis in severe aortic regurgitation with preserved ejection fraction: a magnetic resonance and histology study Article Swipe
Radka Kočková
,
Zuzana Hlubocká
,
K Mĕdílek
,
Hana Línková
,
E P Paskova
,
Tomáš Mráz
,
Milena Prokopová
,
David Sedmera
,
E K Kelen De Oliviera
,
Štěpán Černý
,
Ivo Skalský
,
Martin Pěnička
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/ehjci/jead119.142
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/ehjci/jead119.142
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Institutional Grant Na Homolce Hospital Background The presence and extent of myocardial fibrosis are associated with poor outcomes in patients with severe aortic regurgitation. In the present study, we tested a correlation between left ventricular (LV) strain derived by using feature-tracking cardiac magnetic resonance (MRI) and diffuse myocardial fibrosis percentage (DMF%) at quantitative histology. Methods A study population included 23 patients (age 51 ± 12 years, 78% males) who underwent perioperative myocardial biopsy during aortic valve surgery for severe aortic regurgitation and who had a satisfactory pre-surgery MRI. Myocardial specimens obtained with a deep needle technique from the basal interventricular septum were stained with picrosirius red, digitalized, and analyzed using Image J software by a pathologist blinded to imaging findings. The DMF% was calculated as a ratio of the total collagen content to the total area. MRI-derived global longitudinal-(GLS), circumferential- (GCS), and radial (GRS) strain, as well as their ratio to heart rate and systolic blood pressure, were assessed using a feature-tracking technique by a certified imager blinded to histological analysis. Results Compared to normal values, all patients showed increased DMF% (19 ± 9%) and decreased GLS (15 ± 2%) despite preserved LV ejection fraction (64 ± 7%). Out of all the imaging parameters, only GLS/heart rate ratio, GCS/heart rate ratio and extracellular volume fraction showed a significant correlation with DMF% (Table 1, Figure 1). In contrast, GLS and GCS only tended to correlate with DMF%. The remaining parameters including GRS did not show a significant association. Patients with focal midwall scar in late gadolinium enhancement imaging (n=8, 35%), which was mainly localized in the basal septum, had similar GLS as than patients without focal scar (14.5±2.3 vs 15.3±2.3, p = 0.768). Conclusions Feature-tracking-derived ratios of LV GLS and GCS over heart rate are the most promising indices for non-invasive assessment of diffuse myocardial fibrosis in severe aortic regurgitation with preserved ejection fraction. Figure 1 Legend Correlation of a GLS/HR ratio 1A) and GLS 1B) with diffuse myocardial fibrosis %. Myocardial histology stained with Picrosirius red (collagen fibers are in red).
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/ehjci/jead119.142
- https://academic.oup.com/ehjcimaging/article-pdf/24/Supplement_1/jead119.142/50623229/jead119.142.pdf
- OA Status
- bronze
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4381125696
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4381125696Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/ehjci/jead119.142Digital Object Identifier
- Title
-
Association between left ventricular strain and fibrosis in severe aortic regurgitation with preserved ejection fraction: a magnetic resonance and histology studyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-06-01Full publication date if available
- Authors
-
Radka Kočková, Zuzana Hlubocká, K Mĕdílek, Hana Línková, E P Paskova, Tomáš Mráz, Milena Prokopová, David Sedmera, E K Kelen De Oliviera, Štěpán Černý, Ivo Skalský, Martin PěničkaList of authors in order
- Landing page
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https://doi.org/10.1093/ehjci/jead119.142Publisher landing page
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https://academic.oup.com/ehjcimaging/article-pdf/24/Supplement_1/jead119.142/50623229/jead119.142.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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bronzeOpen access status per OpenAlex
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https://academic.oup.com/ehjcimaging/article-pdf/24/Supplement_1/jead119.142/50623229/jead119.142.pdfDirect OA link when available
- Concepts
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Ejection fraction, Medicine, Myocardial fibrosis, Cardiology, Interventricular septum, Internal medicine, Magnetic resonance imaging, Regurgitation (circulation), Population, Aortic valve, Heart failure, Radiology, Ventricle, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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