Association Between Long-Term Testosterone Exposure and Major Adverse Cardiovascular Events in Aging Men Article Swipe
Paul Connelly
,
Samuel Owusu Achiaw
,
Jocelyn Friday
,
Frederick K. Ho
,
Claudia Geue
,
Sandosh Padmanabhan
,
Jill P. Pell
,
Daniel Mackay
,
Ruth Dundas
,
Tran Tran
,
Denise Scott Brown
,
Claire Hastie
,
Michael Fleming
,
Alan Stevenson
,
Clea du Toit
,
Jim Lewsey
,
Christian Delles
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1210/jendso/bvaf156
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1210/jendso/bvaf156
Context Hypogonadism is a common endocrine disorder in aging men, associated with adverse cardiometabolic outcomes. Concerns about the cardiovascular (CV) safety of testosterone, an important therapy option for the condition, may be disproportionately influencing treatment decisions. Objective This work aimed to investigate the association between long-term testosterone therapy and major adverse CV events (MACE) in men aged 51 years and older. Methods This retrospective cohort study used linked health data from the National Health Service Greater Glasgow and Clyde population, accessed via the West of Scotland Safe Haven. Men aged 51 years and older as of January 1, 2012, were included. Testosterone exposure was defined as having at least a 2-year interval between the first and last prescription during a 5-year exposure window (2012-2016). Individuals were followed from January 1, 2017, to December 31, 2022. The primary outcome was time to first MACE, defined as a composite of acute myocardial infarction, unstable angina, stroke, heart failure, or CV death. Cox proportional hazards models were used to estimate associations, adjusting for age, ethnicity, socioeconomic deprivation, and comorbidities. Results The study included 440 testosterone-exposed and 136 051 unexposed men. Testosterone exposure was associated with a 54% increased risk of MACE in the unadjusted analysis (hazard ratio [HR]: 1.54; 95% CI, 1.18-2.00), and a 55% increased risk after adjustment (HR: 1.55; 95% CI, 1.19-2.01). Conclusion In this real-world cohort, long-term testosterone therapy was associated with increased CV risk. While recent trials inform short- to medium-term CV safety, this study underscores the need for more longer-term data to fully ascertain the effect of testosterone therapy.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1210/jendso/bvaf156
- https://academic.oup.com/jes/advance-article-pdf/doi/10.1210/jendso/bvaf156/64540783/bvaf156.pdf
- OA Status
- gold
- References
- 35
- OpenAlex ID
- https://openalex.org/W4414924309
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4414924309Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1210/jendso/bvaf156Digital Object Identifier
- Title
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Association Between Long-Term Testosterone Exposure and Major Adverse Cardiovascular Events in Aging MenWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-10-04Full publication date if available
- Authors
-
Paul Connelly, Samuel Owusu Achiaw, Jocelyn Friday, Frederick K. Ho, Claudia Geue, Sandosh Padmanabhan, Jill P. Pell, Daniel Mackay, Ruth Dundas, Tran Tran, Denise Scott Brown, Claire Hastie, Michael Fleming, Alan Stevenson, Clea du Toit, Jim Lewsey, Christian DellesList of authors in order
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https://doi.org/10.1210/jendso/bvaf156Publisher landing page
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https://academic.oup.com/jes/advance-article-pdf/doi/10.1210/jendso/bvaf156/64540783/bvaf156.pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://academic.oup.com/jes/advance-article-pdf/doi/10.1210/jendso/bvaf156/64540783/bvaf156.pdfDirect OA link when available
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0Total citation count in OpenAlex
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35Number of works referenced by this work
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