Association between stroke subtypes and outcomes of endovascular therapy: a post-hoc analysis of the ANGEL-ASPECT Trial Article Swipe
Da Lü
,
Raynald
,
Dapeng Sun
,
Na Zheng
,
Bohao Zhang
,
Leilei Luo
,
Sifei Wang
,
Sihu Pan
,
Yuchao Dou
,
Mengxing Wang
,
Yuesong Pan
,
Xiaochuan Huo
,
Zhongrong Miao
,
Ming Wei
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1136/svn-2024-003115
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1136/svn-2024-003115
Objectives Our study aims to examine the value of endovascular therapy (EVT) and its comparison to medical management (MM) in ischaemic stroke patients accompanied by large artery atherosclerosis (LAA) and non-LAA Methods modified Rankin scale score (mRS) was evaluated at 90 days post the stroke attack and was considered as the primary outcome. Other outcomes measured in this study included score changes of 0–2 and 0–3 on the mRS. The occurrence of symptomatic intracranial haemorrhage at 24 hours after EVT was also measured as a safety endpoint. Logistic regression analysis was used to determine the associations. Results In the LAA group, no significant difference in mRS at 90-day (median IQR 3 (2–5) vs 4 (3–4), 95% CI 0.53 to 2.00, p=0.924), mRS 0–2 and mRS 0–3 was observed between EVT and MM groups. However, in the non-LAA group, patients who underwent EVT had lower 90-day mRS scores (4 (2–5) vs 4 (3–5), generalised OR 1.47, 95% CI 1.14 to 1.88, p<0.001). No interaction effect on the primary outcomes between treatment options and aetiology. More intracranial haemorrhage events within 48 hours were identified in the EVT group for both LAA and non-LAA cohorts (LAA: 40.98% vs 9.62%, relative risk (RR) 4.26, 95% CI 1.76 to 10.34, p<0.001; non-LAA, 52.07% vs 19.65%, RR 2.65, 95% CI 1.90 to 3.70, respectively). Conclusions For large infarcts, EVT may be more effective than MM for patients with non-LAA aetiology, but not for those with LAA stroke. As no interaction effect was found, the benefit of EVT compared with MM did not vary by stroke subtypes.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1136/svn-2024-003115
- OA Status
- gold
- References
- 15
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4402559671
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4402559671Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1136/svn-2024-003115Digital Object Identifier
- Title
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Association between stroke subtypes and outcomes of endovascular therapy: a post-hoc analysis of the ANGEL-ASPECT TrialWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2024Year of publication
- Publication date
-
2024-09-17Full publication date if available
- Authors
-
Da Lü, Raynald, Dapeng Sun, Na Zheng, Bohao Zhang, Leilei Luo, Sifei Wang, Sihu Pan, Yuchao Dou, Mengxing Wang, Yuesong Pan, Xiaochuan Huo, Zhongrong Miao, Ming WeiList of authors in order
- Landing page
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https://doi.org/10.1136/svn-2024-003115Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1136/svn-2024-003115Direct OA link when available
- Concepts
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Post-hoc analysis, Post hoc, Stroke (engine), Medicine, Association (psychology), Clinical trial, Physical medicine and rehabilitation, Internal medicine, Psychology, Engineering, Psychotherapist, Mechanical engineeringTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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15Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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