Association between triglyceride glucose-waist height ratio index, hypothyroidism, and mortality in individuals with hypothyroidism: data from NHANES 2007-2012 Article Swipe
Tingting Peng
,
Xiaohua Gong
,
Weiyi Xu
,
Xuchen Deng
,
Zhongqiu Lu
,
Rujun Chen
,
Dongdong Luo
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-7084974/v1
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-7084974/v1
Background: The aim of this study was to examine the associations between the triglyceride glucose-waist height ratio (TyG-WHtR) index and hypothyroidism, as well as mortality among individuals with hypothyroidism. Methods: Data collected from the National Health and Nutrition Examination Survey (NHANES) database spanning the years 2007 to 2012. 8,437 nonpregnant adults were included in the study. Logistic regression models, cox regression models and restricted cubic spline analyses (RCSs) , as well as Subgroup analysis were employed. Results: Individuals in the fourth quartile of TyG-WHtR had a higher odds ratio (OR) of 1.91 (95% CI= 1.08 ~ 3.39, P=0.026) for subclinical hypothyroidism and an OR of 2.41 (95% CI= 1.03 ~ 5.59, P=0.041) for overt hypothyroidism compared to those in the first quartile. RCSs revealed a linear relationship between TyG-WHtR and subclinical hypothyroidism (P-overall=0.01) and a strong nonlinear association between TyG-WHtR and overt hypothyroidism (P for nonlinearity= 0.043). Cox regression models demonstrated that the adjusted HR for all-cause mortality across the lowest to highest tertiles of TyG-WHtR were 1.00 (reference), 1.59 and 2.40, respectively (P= 0.035). Similar results of the adjusted HR and 95% CI for CVD mortality were revealed (P= 0.041). Subgroup analysis indicated significant interactions between the TyG-WHtR and age, BMI (all P interaction< 0.05) in relation to the all-cause and CVD mortality among those with hypothyroidism. Conclusion:TyG-WHtR exhibited a positive association with an elevated incidence of hypothyroidism. Furthermore, among participants with hypothyroidism, this index was linked to all-cause and CVD mortality.
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Concepts
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-7084974/v1
- OA Status
- gold
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4412926385Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-7084974/v1Digital Object Identifier
- Title
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Association between triglyceride glucose-waist height ratio index, hypothyroidism, and mortality in individuals with hypothyroidism: data from NHANES 2007-2012Work title
- Type
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preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-07-25Full publication date if available
- Authors
-
Tingting Peng, Xiaohua Gong, Weiyi Xu, Xuchen Deng, Zhongqiu Lu, Rujun Chen, Dongdong LuoList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-7084974/v1Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.21203/rs.3.rs-7084974/v1Direct OA link when available
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Waist, Triglyceride, Internal medicine, Medicine, National Health and Nutrition Examination Survey, Waist-to-height ratio, Endocrinology, Body mass index, Demography, Environmental health, Cholesterol, Population, SociologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.that | 152 |
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| abstract_inverted_index.index | 19, 236 |
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| abstract_inverted_index.linked | 238 |
| abstract_inverted_index.lowest | 161 |
| abstract_inverted_index.models | 62, 150 |
| abstract_inverted_index.spline | 66 |
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