Association of changes in body weight and waist circumference with a subsequent risk of developing hypertension in men requiring specific healthcare guidance Article Swipe
Yuya Kitani
,
Yuta Suzuki
,
Hidehiro Kaneko
,
Akira Okada
,
Hiroyuki Morita
,
Katsuhito Fujiu
,
Koichi Node
,
Hideo Yasunaga
,
Norihiko Takeda
,
Naoki Nakagawa
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41440-025-02397-4
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41440-025-02397-4
Although body weight (BW) and waist circumference (WC) reduction are key goals of Japan’s Specific Health Guidance program, limited evidence exists linking these reductions to a lower incidence of hypertension. This study aimed to evaluate the association between changes in BW and WC and the subsequent development of hypertension among men in a nationwide population. We retrospectively analyzed 23,109 men aged 40–64 years who required intensive health guidance and had no prior history of hypertension, using a nationwide database (DeSC Healthcare, Tokyo, Japan) from April 2014 to August 2023. One-year changes in BW and WC were examined for their association with incident hypertension using multivariable Cox regression and cubic spline analyses. During a mean follow-up of 1381 ± 789 days, 4162 men (18.0%) developed hypertension. Greater reductions in BW and WC were associated with a progressively lower risk of hypertension. In multivariable Cox models, BW reductions of ≤ −3.0 kg, −2.9 to −2.0 kg, and −1.9 to −1.0 kg were significantly associated with reduced hypertension risk (HR: 0.74 [95% CI: 0.67–0.82], 0.85 [0.76–0.96], and 0.89 [0.81–0.99], respectively). WC reductions of ≤ -3.0 cm and −2.9 to −2.0 cm were also significantly associated with reduced risk (HR: 0.80 [0.73–0.88] and 0.81 [0.72–0.92], respectively). Cubic spline analyses confirmed a monotonic decrease in hypertension risk with increasing BW and WC reduction. Among men eligible for Specific Health Guidance, one-year reductions in BW and WC were significantly associated with a lower risk of developing hypertension.
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- https://doi.org/10.1038/s41440-025-02397-4
- https://www.nature.com/articles/s41440-025-02397-4.pdf
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Association of changes in body weight and waist circumference with a subsequent risk of developing hypertension in men requiring specific healthcare guidanceWork title
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2025Year of publication
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2025-10-24Full publication date if available
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Yuya Kitani, Yuta Suzuki, Hidehiro Kaneko, Akira Okada, Hiroyuki Morita, Katsuhito Fujiu, Koichi Node, Hideo Yasunaga, Norihiko Takeda, Naoki NakagawaList of authors in order
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https://doi.org/10.1038/s41440-025-02397-4Publisher landing page
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https://www.nature.com/articles/s41440-025-02397-4.pdfDirect link to full text PDF
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hybridOpen access status per OpenAlex
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https://www.nature.com/articles/s41440-025-02397-4.pdfDirect OA link when available
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| primary_location.raw_source_name | Hypertension Research |
| primary_location.landing_page_url | https://doi.org/10.1038/s41440-025-02397-4 |
| publication_date | 2025-10-24 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W2773807345, https://openalex.org/W3090621303, https://openalex.org/W4402406133, https://openalex.org/W2026641012, https://openalex.org/W4367625594, https://openalex.org/W4402950423, https://openalex.org/W2137428285, https://openalex.org/W4293574672, https://openalex.org/W3155438923, https://openalex.org/W4282916261, https://openalex.org/W4394688267, https://openalex.org/W3090962500, https://openalex.org/W2028192802, https://openalex.org/W1978884363, https://openalex.org/W2087584088, https://openalex.org/W1994050458 |
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