Association of childhood neighborhood disadvantage with young adult DNA methylation Article Swipe
Aaron Reuben
,
Karen Sugden
,
Louise Arsenault
,
David L. Corcoran
,
Andrea Danese
,
Helen L. Fisher
,
Terrie E. Moffitt
,
Joanne B. Newbury
,
Candice L. Odgers
,
Joseph A. Prinz
,
Line Jee Hartmann Rasmussen
,
Benjamin Williams
,
Jonathan Mill
,
Avshalom Caspi
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1289/isee.2020.virtual.p-0049
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1289/isee.2020.virtual.p-0049
Importance: DNA methylation has been proposed as an epigenetic mechanism by which the childhood neighborhood environment may influence the genome to compromise adult health.Objective: To determine whether childhood neighborhood disadvantage is associated with differences in DNA methylation by age 18 years.Design: Longitudinal-prospective study of a 1994-95 birth cohort, followed to age 18 years (until September, 2014; 93% retention). Data analysis was performed from March to June 2019.Setting: United Kingdom. Participants: The nationally representative Environmental-Risk Longitudinal Study (N=2,232). Exposures: High-resolution neighborhood data (indexing deprivation, dilapidation, disconnection, and dangerousness) collected across childhood.Main Outcomes and Measures: DNA methylation in whole blood was drawn at age 18. Neighborhood-to-methylation associations were tested using three prespecified approaches: (1) testing probes annotated to candidate genes involved in biological responses to growing up in disadvantaged neighborhoods and investigated in previous epigenetic research (i.e., stress-reactivity and inflammation-related genes), (2) polyepigenetic scores indexing differential methylation in phenotypes associated with growing up in disadvantaged neighborhoods (i.e., obesity, inflammation, and smoking), and (3) a theory-free Epigenome-Wide Association Study (EWAS).Results: 1,619 participants (72.5% of cohort, 806[50%] female) had complete neighborhood and DNA methylation data. Children raised in disadvantaged neighborhoods exhibited differential DNA methylation in genes involved in inflammation (β=.12, 95%CI: .06, .19, p<.001) and exposure to tobacco-smoke (β=.18, 95%CI: .11, .25, p<.001) but not obesity (β=.05, 95%CI: -.01, .11, p=.123). EWAS identified multiple CpG sites at an array-wide significance level of p< 1.16x10−7 in genes involved in the metabolism of hydrocarbons. Neighborhood-to-methylation associations were small but robust to family-level socioeconomic factors and to individual-level tobacco smoking. Conclusions and Relevance: Children raised in disadvantaged neighborhoods enter young-adulthood epigenetically distinct from their more advantaged peers. This may be one mechanism by which the childhood neighborhood environment influences adult health.
Related Topics
Concepts
DNA methylation
Epigenetics
Methylation
Epigenome
Longitudinal study
CpG site
Cohort
Confounding
Twin study
Childhood obesity
Medicine
Obesity
Genetics
Biology
Heritability
Oncology
Internal medicine
Gene
Overweight
Pathology
Gene expression
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1289/isee.2020.virtual.p-0049
- OA Status
- diamond
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3169866519
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3169866519Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1289/isee.2020.virtual.p-0049Digital Object Identifier
- Title
-
Association of childhood neighborhood disadvantage with young adult DNA methylationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-10-26Full publication date if available
- Authors
-
Aaron Reuben, Karen Sugden, Louise Arsenault, David L. Corcoran, Andrea Danese, Helen L. Fisher, Terrie E. Moffitt, Joanne B. Newbury, Candice L. Odgers, Joseph A. Prinz, Line Jee Hartmann Rasmussen, Benjamin Williams, Jonathan Mill, Avshalom CaspiList of authors in order
- Landing page
-
https://doi.org/10.1289/isee.2020.virtual.p-0049Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
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https://doi.org/10.1289/isee.2020.virtual.p-0049Direct OA link when available
- Concepts
-
DNA methylation, Epigenetics, Methylation, Epigenome, Longitudinal study, CpG site, Cohort, Confounding, Twin study, Childhood obesity, Medicine, Obesity, Genetics, Biology, Heritability, Oncology, Internal medicine, Gene, Overweight, Pathology, Gene expressionTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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