Association of plasma placental growth factor with white matter hyperintensities in Alzheimer’s disease Article Swipe
Kazuya Igarashi
,
Tamao Tsukie
,
Kazuo Washiyama
,
Kiyoshi Onda
,
Yasuo Miyagi
,
Shoya Inagawa
,
Soichiro Shimizu
,
Akinori Miyashita
,
Osamu Onodera
,
Takeshi Ikeuchi
,
Kensaku Kasuga
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.06.24.25330230
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.06.24.25330230
Background The global prevalence of dementia, particularly Alzheimer’s disease (AD), is increasing. With the introduction of anti-β-amyloid (Aβ) antibody drugs, the accurate in vivo diagnosis of AD has become crucial. Autopsy studies have shown that AD often coexists with cerebrovascular injury, which may affect cognitive outcomes and the effectiveness of anti-Aβ drugs. Although white matter hyperintensity (WMH) on magnetic resonance imaging (MRI) is an established marker of cerebrovascular injury, no fluid biomarker has been identified. Objective This study investigated the association between WMH severity and fluid biomarkers, including cerebrospinal fluid (CSF) neurofilament light chain and plasma placental growth factor (PlGF) levels. Methods The study included 242 patients from memory clinics, and MRI, CSF, and plasma samples were collected. Patients were classified as AD+ or non-AD based on the CSF Aβ42/Aβ40 ratio. In the discovery cohort (79 AD+ and 20 non-AD patients with 3D-T1 images), we analyzed the association between WMH volume and plasma PlGF. In the validation cohort (54 AD+ patients without 3D-T1 images), we analyzed the association between WMH grading and plasma PlGF. Results Among AD+ patients in the discovery cohort, plasma PlGF levels remained significantly associated with WMH volume and grading after adjusting for age, sex, and global cognition. Among the AD+ patients in the validation cohort, the high-PlGF (above median) group had significantly greater WMH volumes and a higher number of patients with a high WMH grading than the low-PlGF (below median) group. Conclusions Plasma PlGF is a promising marker of cerebrovascular injury in AD.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2025.06.24.25330230
- https://www.medrxiv.org/content/medrxiv/early/2025/06/25/2025.06.24.25330230.full.pdf
- OA Status
- green
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411628715
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4411628715Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2025.06.24.25330230Digital Object Identifier
- Title
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Association of plasma placental growth factor with white matter hyperintensities in Alzheimer’s diseaseWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-06-25Full publication date if available
- Authors
-
Kazuya Igarashi, Tamao Tsukie, Kazuo Washiyama, Kiyoshi Onda, Yasuo Miyagi, Shoya Inagawa, Soichiro Shimizu, Akinori Miyashita, Osamu Onodera, Takeshi Ikeuchi, Kensaku KasugaList of authors in order
- Landing page
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https://doi.org/10.1101/2025.06.24.25330230Publisher landing page
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https://www.medrxiv.org/content/medrxiv/early/2025/06/25/2025.06.24.25330230.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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-
greenOpen access status per OpenAlex
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https://www.medrxiv.org/content/medrxiv/early/2025/06/25/2025.06.24.25330230.full.pdfDirect OA link when available
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Hyperintensity, Association (psychology), White matter, Disease, Medicine, Internal medicine, Psychology, Magnetic resonance imaging, Radiology, PsychotherapistTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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52Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.(AD), | 10 |
| abstract_inverted_index.(Aβ) | 18 |
| abstract_inverted_index.(CSF) | 91 |
| abstract_inverted_index.(MRI) | 62 |
| abstract_inverted_index.(WMH) | 57 |
| abstract_inverted_index.3D-T1 | 143, 163 |
| abstract_inverted_index.Among | 176, 202 |
| abstract_inverted_index.PlGF. | 154, 174 |
| abstract_inverted_index.after | 194 |
| abstract_inverted_index.based | 126 |
| abstract_inverted_index.chain | 94 |
| abstract_inverted_index.fluid | 71, 86, 90 |
| abstract_inverted_index.group | 214 |
| abstract_inverted_index.light | 93 |
| abstract_inverted_index.often | 37 |
| abstract_inverted_index.shown | 34 |
| abstract_inverted_index.study | 78, 104 |
| abstract_inverted_index.which | 42 |
| abstract_inverted_index.white | 54 |
| abstract_inverted_index.(PlGF) | 100 |
| abstract_inverted_index.(above | 212 |
| abstract_inverted_index.(below | 234 |
| abstract_inverted_index.Plasma | 238 |
| abstract_inverted_index.affect | 44 |
| abstract_inverted_index.become | 29 |
| abstract_inverted_index.cohort | 135, 158 |
| abstract_inverted_index.drugs, | 20 |
| abstract_inverted_index.drugs. | 52 |
| abstract_inverted_index.factor | 99 |
| abstract_inverted_index.global | 3, 200 |
| abstract_inverted_index.group. | 236 |
| abstract_inverted_index.growth | 98 |
| abstract_inverted_index.higher | 222 |
| abstract_inverted_index.injury | 246 |
| abstract_inverted_index.levels | 185 |
| abstract_inverted_index.marker | 66, 243 |
| abstract_inverted_index.matter | 55 |
| abstract_inverted_index.memory | 109 |
| abstract_inverted_index.non-AD | 125, 140 |
| abstract_inverted_index.number | 223 |
| abstract_inverted_index.plasma | 96, 115, 153, 173, 183 |
| abstract_inverted_index.ratio. | 131 |
| abstract_inverted_index.volume | 151, 191 |
| abstract_inverted_index.Autopsy | 31 |
| abstract_inverted_index.Methods | 102 |
| abstract_inverted_index.Results | 175 |
| abstract_inverted_index.between | 82, 149, 169 |
| abstract_inverted_index.cohort, | 182, 209 |
| abstract_inverted_index.disease | 9 |
| abstract_inverted_index.grading | 171, 193, 230 |
| abstract_inverted_index.greater | 217 |
| abstract_inverted_index.imaging | 61 |
| abstract_inverted_index.injury, | 41, 69 |
| abstract_inverted_index.levels. | 101 |
| abstract_inverted_index.median) | 213, 235 |
| abstract_inverted_index.samples | 116 |
| abstract_inverted_index.studies | 32 |
| abstract_inverted_index.volumes | 219 |
| abstract_inverted_index.without | 162 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Although | 53 |
| abstract_inverted_index.Patients | 119 |
| abstract_inverted_index.accurate | 22 |
| abstract_inverted_index.analyzed | 146, 166 |
| abstract_inverted_index.anti-Aβ | 51 |
| abstract_inverted_index.antibody | 19 |
| abstract_inverted_index.clinics, | 110 |
| abstract_inverted_index.coexists | 38 |
| abstract_inverted_index.crucial. | 30 |
| abstract_inverted_index.images), | 144, 164 |
| abstract_inverted_index.included | 105 |
| abstract_inverted_index.low-PlGF | 233 |
| abstract_inverted_index.magnetic | 59 |
| abstract_inverted_index.outcomes | 46 |
| abstract_inverted_index.patients | 107, 141, 161, 178, 205, 225 |
| abstract_inverted_index.remained | 186 |
| abstract_inverted_index.severity | 84 |
| abstract_inverted_index.Objective | 76 |
| abstract_inverted_index.adjusting | 195 |
| abstract_inverted_index.biomarker | 72 |
| abstract_inverted_index.cognitive | 45 |
| abstract_inverted_index.dementia, | 6 |
| abstract_inverted_index.diagnosis | 25 |
| abstract_inverted_index.discovery | 134, 181 |
| abstract_inverted_index.high-PlGF | 211 |
| abstract_inverted_index.including | 88 |
| abstract_inverted_index.placental | 97 |
| abstract_inverted_index.promising | 242 |
| abstract_inverted_index.resonance | 60 |
| abstract_inverted_index.Background | 1 |
| abstract_inverted_index.associated | 188 |
| abstract_inverted_index.classified | 121 |
| abstract_inverted_index.cognition. | 201 |
| abstract_inverted_index.collected. | 118 |
| abstract_inverted_index.prevalence | 4 |
| abstract_inverted_index.validation | 157, 208 |
| abstract_inverted_index.Aβ42/Aβ40 | 130 |
| abstract_inverted_index.Conclusions | 237 |
| abstract_inverted_index.association | 81, 148, 168 |
| abstract_inverted_index.biomarkers, | 87 |
| abstract_inverted_index.established | 65 |
| abstract_inverted_index.identified. | 75 |
| abstract_inverted_index.increasing. | 12 |
| abstract_inverted_index.introduction | 15 |
| abstract_inverted_index.investigated | 79 |
| abstract_inverted_index.particularly | 7 |
| abstract_inverted_index.Alzheimer’s | 8 |
| abstract_inverted_index.cerebrospinal | 89 |
| abstract_inverted_index.effectiveness | 49 |
| abstract_inverted_index.neurofilament | 92 |
| abstract_inverted_index.significantly | 187, 216 |
| abstract_inverted_index.hyperintensity | 56 |
| abstract_inverted_index.anti-β-amyloid | 17 |
| abstract_inverted_index.cerebrovascular | 40, 68, 245 |
| cited_by_percentile_year | |
| countries_distinct_count | 0 |
| institutions_distinct_count | 11 |
| citation_normalized_percentile.value | 0.2429112 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |