Association of the retinal vasculature, intrathecal immunity, and disability in multiple sclerosis Article Swipe
Christina Noll
,
Michael Hiltensperger
,
Lilian Aly
,
Rebecca Wicklein
,
Ali Maisam Afzali
,
Christian Y. Mardin
,
Christiane Gasperi
,
Achim Berthele
,
Bernhard Hemmer
,
Thomas Korn
,
Benjamin Knier
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2022.997043
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2022.997043
Background Optical coherence tomography angiography (OCT-A) is a novel technique allowing non-invasive assessment of the retinal vasculature. During relapsing remitting multiple sclerosis (RRMS), retinal vessel loss occurs in eyes suffering from acute optic neuritis and recent data suggest that retinal vessel loss might also be evident in non-affected eyes. We investigated whether alterations of the retinal vasculature are linked to the intrathecal immunity and whether they allow prognostication of the future disease course. Material and methods This study includes two different patient cohorts recruited at a tertiary German academic multiple sclerosis center between 2018 and 2020 and a cohort of 40 healthy controls. A total of 90 patients with RRMS undergoing lumbar puncture and OCT-A analysis were enrolled into a cross-sectional cohort study to search for associations between the retinal vasculature and the intrathecal immune compartment. We recruited another 86 RRMS patients into a prospective observational cohort study who underwent clinical examination, OCT-A and cerebral magnetic resonance imaging at baseline and during annual follow-up visits to clarify whether alterations of the retinal vessels are linked to RRMS disease activity. Eyes with a history of optic neuritis were excluded from the analysis. Results Rarefication of the superficial vascular complex occured during RRMS and was linked to higher frequencies of activated B cells and higher levels of the pro-inflammatory cytokines interferon-γ, tumor necrosis factor α and interleukin-17 in the cerebrospinal fluid. During a median follow-up of 23 (interquartile range 14 - 25) months, vessel loss within the superficial (hazard ratio [HR] 1.6 for a 1%-point decrease in vessel density, p=0.01) and deep vascular complex (HR 1.6 for a 1%-point decrease, p=0.05) was associated with future disability worsening. Discussion Optic neuritis independent rarefication of the retinal vasculature might be linked to neuroinflammatory processes during RRMS and might predict a worse disease course. Thus, OCT-A might be a novel biomarker to monitor disease activity and predict future disability.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fimmu.2022.997043
- OA Status
- gold
- Cited By
- 15
- References
- 40
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4308938830
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4308938830Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fimmu.2022.997043Digital Object Identifier
- Title
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Association of the retinal vasculature, intrathecal immunity, and disability in multiple sclerosisWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
-
2022-11-11Full publication date if available
- Authors
-
Christina Noll, Michael Hiltensperger, Lilian Aly, Rebecca Wicklein, Ali Maisam Afzali, Christian Y. Mardin, Christiane Gasperi, Achim Berthele, Bernhard Hemmer, Thomas Korn, Benjamin KnierList of authors in order
- Landing page
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https://doi.org/10.3389/fimmu.2022.997043Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3389/fimmu.2022.997043Direct OA link when available
- Concepts
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Multiple sclerosis, Retinal, Medicine, Immunity, Association (psychology), Immunology, Neuroscience, Ophthalmology, Immune system, Biology, Psychology, PsychotherapistTop concepts (fields/topics) attached by OpenAlex
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15Total citation count in OpenAlex
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2025: 7, 2024: 4, 2023: 4Per-year citation counts (last 5 years)
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40Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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