Association of the Stroke Ready Community-Based Participatory Research Intervention With Incidence of Acute Stroke Thrombolysis in Flint, Michigan Article Swipe
YOU?
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· 2023
· Open Access
·
· DOI: https://doi.org/10.1001/jamanetworkopen.2023.21558
Importance Acute stroke treatment rates in the US lag behind those in other high-income nations. Objective To assess whether a hospital emergency department (ED) and community intervention was associated with an increased proportion of patients with stroke receiving thrombolysis. Design, Setting, and Participants This nonrandomized controlled trial of the Stroke Ready intervention took place in Flint, Michigan, from October 2017 to March 2020. Participants included adults living in the community. Data analysis was completed from July 2022 to May 2023. Intervention Stroke Ready combined implementation science and community-based participatory research approaches. Acute stroke care was optimized in a safety-net ED, and then a community-wide, theory-based health behavior intervention, including peer-led workshops, mailers, and social media, was conducted. Main Outcomes and Measures The prespecified primary outcome was the proportion of patients hospitalized with ischemic stroke or transient ischemic attack from Flint who received thrombolysis before and after the intervention. The association between thrombolysis and the Stroke Ready combined intervention, including the ED and community components, was estimated using logistic regression models, clustering at the hospital level and adjusting for time and stroke type. In prespecified secondary analyses, the ED and community intervention were explored separately, adjusting for hospital, time, and stroke type. Results In total, 5970 people received in-person stroke preparedness workshops, corresponding to 9.7% of the adult population in Flint. There were 3327 ischemic stroke and TIA visits (1848 women [55.6%]; 1747 Black individuals [52.5%]; mean [SD] age, 67.8 [14.5] years) among patients from Flint seen in the relevant EDs, including 2305 in the preintervention period from July 2010 to September 2017 and 1022 in the postintervention period from October 2017 to March 2020. The proportion of thrombolysis usage increased from 4% in 2010 to 14% in 2020. The combined Stroke Ready intervention was not associated with thrombolysis use (adjusted odds ratio [OR], 1.13; 95% CI, 0.74-1.70; P = .58). The ED component was associated with an increase in thrombolysis use (adjusted OR, 1.63; 95% CI, 1.04-2.56; P = .03), but the community component was not (adjusted OR, 0.99; 95% CI, 0.96-1.01; P = .30). Conclusions and Relevance This nonrandomized controlled trial found that a multilevel ED and community stroke preparedness intervention was not associated with increased thrombolysis treatments. The ED intervention was associated with increased thrombolysis usage, suggesting that implementation strategies in partnership with safety-net hospitals may increase thrombolysis usage. Trial Registration ClinicalTrials.gov Identifier: NCT036455900
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1001/jamanetworkopen.2023.21558
- https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2806833/skolarus_2023_oi_230635_1687872013.90444.pdf
- OA Status
- gold
- Cited By
- 8
- References
- 34
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4382918140
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4382918140Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1001/jamanetworkopen.2023.21558Digital Object Identifier
- Title
-
Association of the Stroke Ready Community-Based Participatory Research Intervention With Incidence of Acute Stroke Thrombolysis in Flint, MichiganWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-07-03Full publication date if available
- Authors
-
Lesli E. Skolarus, Sarah Bailey, Casey L. Corches, Anne Sales, Chun Chieh Lin, Ran Bi, Mellanie V. Springer, Alina Oliver, Maria Cielito Robles, Tia Brooks, Michael Tupper, Michael Jaggi, Mohammed Al‐Qasmi, Bruce A. Trevithick, Kimberly Barber, Aniel Majjhoo, Marc A. Zimmerman, William J. Meurer, Devin L. Brown, Lewis B. Morgenstern, James BurkeList of authors in order
- Landing page
-
https://doi.org/10.1001/jamanetworkopen.2023.21558Publisher landing page
- PDF URL
-
https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2806833/skolarus_2023_oi_230635_1687872013.90444.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2806833/skolarus_2023_oi_230635_1687872013.90444.pdfDirect OA link when available
- Concepts
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Thrombolysis, Stroke (engine), Acute stroke, Medicine, Incidence (geometry), Intervention (counseling), Association (psychology), Community-based participatory research, Participatory action research, Gerontology, Internal medicine, Psychology, Tissue plasminogen activator, Nursing, Sociology, Engineering, Myocardial infarction, Anthropology, Optics, Psychotherapist, Physics, Mechanical engineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
8Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 5, 2023: 1Per-year citation counts (last 5 years)
- References (count)
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34Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.partnership | 383 |
| abstract_inverted_index.separately, | 193 |
| abstract_inverted_index.treatments. | 368 |
| abstract_inverted_index.Intervention | 80 |
| abstract_inverted_index.NCT036455900 | 395 |
| abstract_inverted_index.Participants | 42, 63 |
| abstract_inverted_index.Registration | 392 |
| abstract_inverted_index.hospitalized | 130 |
| abstract_inverted_index.intervention | 26, 51, 190, 292, 361, 371 |
| abstract_inverted_index.preparedness | 209, 360 |
| abstract_inverted_index.prespecified | 122, 183 |
| abstract_inverted_index.theory-based | 104 |
| abstract_inverted_index.thrombolysis | 142, 151, 277, 297, 319, 367, 376, 389 |
| abstract_inverted_index.corresponding | 211 |
| abstract_inverted_index.intervention, | 107, 157 |
| abstract_inverted_index.intervention. | 147 |
| abstract_inverted_index.nonrandomized | 44, 349 |
| abstract_inverted_index.participatory | 88 |
| abstract_inverted_index.thrombolysis. | 38 |
| abstract_inverted_index.implementation | 84, 380 |
| abstract_inverted_index.community-based | 87 |
| abstract_inverted_index.community-wide, | 103 |
| abstract_inverted_index.preintervention | 254 |
| abstract_inverted_index.postintervention | 266 |
| abstract_inverted_index.ClinicalTrials.gov | 393 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5045673630 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 21 |
| corresponding_institution_ids | https://openalex.org/I111979921, https://openalex.org/I27837315 |
| citation_normalized_percentile.value | 0.87432636 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |