Association of Zinc Finger Antiviral Protein Binding to Viral Genomic RNA with Attenuation of Replication of Echovirus 7 Article Swipe

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Niluka Goonawardane , Dung Nguyen , Peter Simmonds ·

YOU? · · 2021 · Open Access · · DOI: https://doi.org/10.1128/msphere.01138-20

We recently discovered that the OAS3/RNase L antiviral pathway is essential for restriction of CpG- and UpA-enriched viruses, in addition to the requirement for zinc finger antiviral protein (ZAP). The current study provides evidence for the specific dinucleotide and wider recognition contexts associated with virus recognition and attenuation.

Related Topics

Zinc Finger

Biology

Rna

Computational Biology

Gene Expression

Concepts

Zinc finger Biology Virology RNase P Zinc finger nuclease RNA CpG site Computational biology Genetics Gene DNA methylation Transcription factor Gene expression

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Type: article
Language: en
Landing Page: https://doi.org/10.1128/msphere.01138-20
OA Status: gold
Cited By: 19
References: 36
Related Works: 10
OpenAlex ID: https://openalex.org/W3118979198

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OpenAlex ID: https://openalex.org/W3118979198

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DOI: https://doi.org/10.1128/msphere.01138-20

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Title: Association of Zinc Finger Antiviral Protein Binding to Viral Genomic RNA with Attenuation of Replication of Echovirus 7

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Type: article

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Language: en

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Publication year: 2021

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Publication date: 2021-01-05

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Authors: Niluka Goonawardane, Dung Nguyen, Peter Simmonds

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Landing page: https://doi.org/10.1128/msphere.01138-20

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OA URL: https://doi.org/10.1128/msphere.01138-20

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Concepts: Zinc finger, Biology, Virology, RNase P, Zinc finger nuclease, RNA, CpG site, Computational biology, Genetics, Gene, DNA methylation, Transcription factor, Gene expression

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Cited by: 19

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Citations by year (recent): 2025: 5, 2024: 2, 2023: 6, 2022: 2, 2021: 4

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References (count): 36

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