Associations of COVID-19 Symptoms with Omicron Subvariants BA.2 and BA.5, Host Status, and Clinical Outcomes: A Registry-Based Observational Study in Sapporo, Japan Article Swipe
Sho Nakakubo
,
Naoki Kishida
,
Kenichi Okuda
,
Keisuke Kamada
,
Masami Iwama
,
Masaru Suzuki
,
Isao Yokota
,
Yoichi M. Ito
,
Yasuyuki Nasuhara
,
Richard C. Boucher
,
Satoshi Konno
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.02.02.23285393
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.02.02.23285393
Background Previous SARS-CoV-2 infection and vaccination, coupled to rapid evolution of SARS-CoV-2 variants, have modified COVID-19 clinical manifestations. We characterized clinical symptoms of COVID-19 individuals in omicron BA.2 and BA.5 Japanese pandemic periods to identify omicron and subvariant associations between symptoms, immune status, and clinical outcomes. Methods Individuals registered in Sapporo’s web-based COVID-19 information system entered 12 pre-selected symptoms, days since symptom onset, vaccination history, SARS-CoV-2 infection history, and background. Symptom frequencies, variables associated with symptoms, and symptoms associated with progression to severe disease were analysed. Results For all omicron-infected individuals, cough was the most common symptom (62.7%), followed by sore throat (60.7%), nasal discharge (44.3%), and fever (38.8%). Omicron BA.5 infection was associated with a higher symptom burden than BA.2 in vaccinated and unvaccinated individuals. Omicron breakthrough-infected individuals with ≥ 3 vaccinations or previous infection were less likely to exhibit systemic symptoms, but more likely to exhibit upper respiratory symptoms. Infected elderly individuals had lower odds for all symptoms, but, when symptoms were manifest, systemic symptoms were associated with an increased risk, whereas upper respiratory symptoms with a decreased risk, of severe disease. Conclusion Host immunological status, omicron subvariant, and age were associated with a spectrum of COVID-19 symptoms and outcomes. BA.5 produced a greater symptom burden than BA.2. Vaccination and prior infection mitigated systemic symptoms and improved outcomes, but increased upper respiratory tract symptom burden. Systemic, but not upper respiratory, symptoms in the elderly heralded severe disease.
Related Topics
Concepts
Medicine
Sore throat
Vaccination
Disease
Internal medicine
Pandemic
Coronavirus disease 2019 (COVID-19)
Pediatrics
Immunology
Infectious disease (medical specialty)
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2023.02.02.23285393
- https://www.medrxiv.org/content/medrxiv/early/2023/02/07/2023.02.02.23285393.full.pdf
- OA Status
- green
- Cited By
- 5
- References
- 33
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4319341672
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4319341672Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2023.02.02.23285393Digital Object Identifier
- Title
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Associations of COVID-19 Symptoms with Omicron Subvariants BA.2 and BA.5, Host Status, and Clinical Outcomes: A Registry-Based Observational Study in Sapporo, JapanWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-02-07Full publication date if available
- Authors
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Sho Nakakubo, Naoki Kishida, Kenichi Okuda, Keisuke Kamada, Masami Iwama, Masaru Suzuki, Isao Yokota, Yoichi M. Ito, Yasuyuki Nasuhara, Richard C. Boucher, Satoshi KonnoList of authors in order
- Landing page
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https://doi.org/10.1101/2023.02.02.23285393Publisher landing page
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https://www.medrxiv.org/content/medrxiv/early/2023/02/07/2023.02.02.23285393.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.medrxiv.org/content/medrxiv/early/2023/02/07/2023.02.02.23285393.full.pdfDirect OA link when available
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Medicine, Sore throat, Vaccination, Disease, Internal medicine, Pandemic, Coronavirus disease 2019 (COVID-19), Pediatrics, Immunology, Infectious disease (medical specialty)Top concepts (fields/topics) attached by OpenAlex
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5Total citation count in OpenAlex
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2024: 2, 2023: 3Per-year citation counts (last 5 years)
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33Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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