Associations of novel blood-derived markers of inflammation with blood pressure, arterial stiffness and heart rate in young adults Article Swipe
Richard J. Woodman
,
Angelo Zinellu
,
Trevor A. Mori
,
Lawrie J Beilin
,
Arduino A Mangoni
,
Arduino A Mangoni
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fcvm.2025.1678178
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fcvm.2025.1678178
Background Although C-reactive protein (CRP) is often used to assess inflammation and can predict high blood pressure (BP) and arterial stiffness, novel measures of inflammation derived from platelets, white blood cell counts, and high-density lipoprotein cholesterol (HDL-C) may also indicate possible hypertension and arterial stiffening. Methods We assessed the association between CRP and novel inflammatory markers and clinical BP, arterial stiffness, and heart rate (HR) in Gen2 Raine Study participants in Western Australia aged 17–22 years. Arterial stiffness was assessed using pulse-wave velocity (PWV), augmentation index (AIx), and pulse pressure (PP). Inflammatory markers included high-sensitivity CRP (hsCRP); hsCRP-to-albumin ratio; lymphocyte, monocyte, neutrophil, and platelet counts; neutrophil-to-lymphocyte ratio (NLR); platelet-to-lymphocyte ratio (PLR); mean platelet volume; neutrophil percentage-to-albumin ratio; monocyte/HDL-C ratio; neutrophil/HDL-C ratio; Prognostic Nutritional Index and the Systemic Inflammation Index (SII). Results Males ( N = 363) had higher systolic BP (SBP) ( Δ = 9.1 mmHg, p < 0.001), lower diastolic BP (DBP) ( Δ = −0.9 mmHg, p < 0.001), and higher PWV ( Δ = 0.37 m/sec; p < 0.001) than females ( N = 330). The lymphocyte count, monocyte/HDL-C ratio, and neutrophil/HDL-C ratio were positively associated with SBP, PP, and AIx. The platelet count was positively associated with SBP, DBP, and PP. Most inflammatory indices were associated with HR, and associations with SBP, DBP, AIx, and PWV were stronger in males than in females. The hsCRP and SII levels were not associated with SBP, DBP, PP, AIx, or PWV. Conclusions The lymphocyte count, monocyte/HDL-C ratio, neutrophil/HDL-C ratio, and platelet count showed more robust associations with blood pressure and arterial stiffness in young adults compared to hsCRP and SII, suggesting their potential utility in this specific context.
Related Topics
Concepts
Arterial stiffness
Medicine
Blood pressure
Internal medicine
Pulse wave velocity
Cardiology
Inflammation
Heart rate
Systemic inflammation
Platelet
White blood cell
Diastole
Pulse pressure
Platelet activation
C-reactive protein
Neutrophil to lymphocyte ratio
Young adult
Lymphocyte
Mean platelet volume
Body mass index
Erythrocyte sedimentation rate
Mean arterial pressure
Arterial blood
Heart failure
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fcvm.2025.1678178
- https://public-pages-files-2025.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1678178/pdf
- OA Status
- gold
- References
- 42
- OpenAlex ID
- https://openalex.org/W7106523777
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W7106523777Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fcvm.2025.1678178Digital Object Identifier
- Title
-
Associations of novel blood-derived markers of inflammation with blood pressure, arterial stiffness and heart rate in young adultsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-11-25Full publication date if available
- Authors
-
Richard J. Woodman, Angelo Zinellu, Trevor A. Mori, Lawrie J Beilin, Arduino A Mangoni, Arduino A MangoniList of authors in order
- Landing page
-
https://doi.org/10.3389/fcvm.2025.1678178Publisher landing page
- PDF URL
-
https://public-pages-files-2025.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1678178/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://public-pages-files-2025.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1678178/pdfDirect OA link when available
- Concepts
-
Arterial stiffness, Medicine, Blood pressure, Internal medicine, Pulse wave velocity, Cardiology, Inflammation, Heart rate, Systemic inflammation, Platelet, White blood cell, Diastole, Pulse pressure, Platelet activation, C-reactive protein, Neutrophil to lymphocyte ratio, Young adult, Lymphocyte, Mean platelet volume, Body mass index, Erythrocyte sedimentation rate, Mean arterial pressure, Arterial blood, Heart failureTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
42Number of works referenced by this work
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| abstract_inverted_index.= | 134, 143, 155, 166, 176 |
| abstract_inverted_index.N | 133, 175 |
| abstract_inverted_index.p | 146, 158, 169 |
| abstract_inverted_index.BP | 139, 151 |
| abstract_inverted_index.We | 46 |
| abstract_inverted_index.in | 65, 70, 222, 225, 263, 275 |
| abstract_inverted_index.is | 5 |
| abstract_inverted_index.of | 23 |
| abstract_inverted_index.or | 240 |
| abstract_inverted_index.to | 8, 267 |
| abstract_inverted_index.Δ | 142, 154, 165 |
| abstract_inverted_index.9.1 | 144 |
| abstract_inverted_index.BP, | 58 |
| abstract_inverted_index.CRP | 51, 95 |
| abstract_inverted_index.HR, | 211 |
| abstract_inverted_index.PP, | 191, 238 |
| abstract_inverted_index.PP. | 204 |
| abstract_inverted_index.PWV | 163, 219 |
| abstract_inverted_index.SII | 230 |
| abstract_inverted_index.The | 178, 194, 227, 243 |
| abstract_inverted_index.and | 11, 18, 32, 42, 52, 56, 61, 87, 102, 124, 161, 183, 192, 203, 212, 218, 229, 250, 260, 269 |
| abstract_inverted_index.can | 12 |
| abstract_inverted_index.had | 136 |
| abstract_inverted_index.may | 37 |
| abstract_inverted_index.not | 233 |
| abstract_inverted_index.the | 48, 125 |
| abstract_inverted_index.was | 78, 197 |
| abstract_inverted_index.(BP) | 17 |
| abstract_inverted_index.(HR) | 64 |
| abstract_inverted_index.0.37 | 167 |
| abstract_inverted_index.363) | 135 |
| abstract_inverted_index.AIx, | 217, 239 |
| abstract_inverted_index.AIx. | 193 |
| abstract_inverted_index.DBP, | 202, 216, 237 |
| abstract_inverted_index.Gen2 | 66 |
| abstract_inverted_index.Most | 205 |
| abstract_inverted_index.PWV. | 241 |
| abstract_inverted_index.SBP, | 190, 201, 215, 236 |
| abstract_inverted_index.SII, | 270 |
| abstract_inverted_index.aged | 73 |
| abstract_inverted_index.also | 38 |
| abstract_inverted_index.cell | 30 |
| abstract_inverted_index.from | 26 |
| abstract_inverted_index.high | 14 |
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| abstract_inverted_index.more | 254 |
| abstract_inverted_index.rate | 63 |
| abstract_inverted_index.than | 172, 224 |
| abstract_inverted_index.this | 276 |
| abstract_inverted_index.used | 7 |
| abstract_inverted_index.were | 186, 208, 220, 232 |
| abstract_inverted_index.with | 189, 200, 210, 214, 235, 257 |
| abstract_inverted_index.(CRP) | 4 |
| abstract_inverted_index.(DBP) | 152 |
| abstract_inverted_index.(PP). | 90 |
| abstract_inverted_index.(SBP) | 140 |
| abstract_inverted_index.330). | 177 |
| abstract_inverted_index.Index | 123, 128 |
| abstract_inverted_index.Males | 131 |
| abstract_inverted_index.Raine | 67 |
| abstract_inverted_index.Study | 68 |
| abstract_inverted_index.blood | 15, 29, 258 |
| abstract_inverted_index.count | 196, 252 |
| abstract_inverted_index.heart | 62 |
| abstract_inverted_index.hsCRP | 228, 268 |
| abstract_inverted_index.index | 85 |
| abstract_inverted_index.lower | 149 |
| abstract_inverted_index.males | 223 |
| abstract_inverted_index.mmHg, | 145, 157 |
| abstract_inverted_index.novel | 21, 53 |
| abstract_inverted_index.often | 6 |
| abstract_inverted_index.pulse | 88 |
| abstract_inverted_index.ratio | 106, 109, 185 |
| abstract_inverted_index.their | 272 |
| abstract_inverted_index.using | 80 |
| abstract_inverted_index.white | 28 |
| abstract_inverted_index.young | 264 |
| abstract_inverted_index.(AIx), | 86 |
| abstract_inverted_index.(NLR); | 107 |
| abstract_inverted_index.(PLR); | 110 |
| abstract_inverted_index.(PWV), | 83 |
| abstract_inverted_index.(SII). | 129 |
| abstract_inverted_index.0.001) | 171 |
| abstract_inverted_index.adults | 265 |
| abstract_inverted_index.assess | 9 |
| abstract_inverted_index.count, | 180, 245 |
| abstract_inverted_index.higher | 137, 162 |
| abstract_inverted_index.levels | 231 |
| abstract_inverted_index.m/sec; | 168 |
| abstract_inverted_index.ratio, | 182, 247, 249 |
| abstract_inverted_index.ratio; | 98, 116, 118, 120 |
| abstract_inverted_index.robust | 255 |
| abstract_inverted_index.showed | 253 |
| abstract_inverted_index.years. | 75 |
| abstract_inverted_index.−0.9 | 156 |
| abstract_inverted_index.(HDL-C) | 36 |
| abstract_inverted_index.0.001), | 148, 160 |
| abstract_inverted_index.17–22 | 74 |
| abstract_inverted_index.Methods | 45 |
| abstract_inverted_index.Results | 130 |
| abstract_inverted_index.Western | 71 |
| abstract_inverted_index.between | 50 |
| abstract_inverted_index.counts, | 31 |
| abstract_inverted_index.counts; | 104 |
| abstract_inverted_index.derived | 25 |
| abstract_inverted_index.females | 173 |
| abstract_inverted_index.indices | 207 |
| abstract_inverted_index.markers | 55, 92 |
| abstract_inverted_index.predict | 13 |
| abstract_inverted_index.protein | 3 |
| abstract_inverted_index.utility | 274 |
| abstract_inverted_index.volume; | 113 |
| abstract_inverted_index.&lt; | 147, 159, 170 |
| abstract_inverted_index.(hsCRP); | 96 |
| abstract_inverted_index.Although | 1 |
| abstract_inverted_index.Arterial | 76 |
| abstract_inverted_index.Systemic | 126 |
| abstract_inverted_index.arterial | 19, 43, 59, 261 |
| abstract_inverted_index.assessed | 47, 79 |
| abstract_inverted_index.clinical | 57 |
| abstract_inverted_index.compared | 266 |
| abstract_inverted_index.context. | 278 |
| abstract_inverted_index.females. | 226 |
| abstract_inverted_index.included | 93 |
| abstract_inverted_index.indicate | 39 |
| abstract_inverted_index.measures | 22 |
| abstract_inverted_index.platelet | 103, 112, 195, 251 |
| abstract_inverted_index.possible | 40 |
| abstract_inverted_index.pressure | 16, 89, 259 |
| abstract_inverted_index.specific | 277 |
| abstract_inverted_index.stronger | 221 |
| abstract_inverted_index.systolic | 138 |
| abstract_inverted_index.velocity | 82 |
| abstract_inverted_index.Australia | 72 |
| abstract_inverted_index.diastolic | 150 |
| abstract_inverted_index.monocyte, | 100 |
| abstract_inverted_index.potential | 273 |
| abstract_inverted_index.stiffness | 77, 262 |
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| abstract_inverted_index.Prognostic | 121 |
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| abstract_inverted_index.lymphocyte | 179, 244 |
| abstract_inverted_index.neutrophil | 114 |
| abstract_inverted_index.platelets, | 27 |
| abstract_inverted_index.positively | 187, 198 |
| abstract_inverted_index.pulse-wave | 81 |
| abstract_inverted_index.stiffness, | 20, 60 |
| abstract_inverted_index.suggesting | 271 |
| abstract_inverted_index.Conclusions | 242 |
| abstract_inverted_index.Nutritional | 122 |
| abstract_inverted_index.association | 49 |
| abstract_inverted_index.cholesterol | 35 |
| abstract_inverted_index.lipoprotein | 34 |
| abstract_inverted_index.lymphocyte, | 99 |
| abstract_inverted_index.neutrophil, | 101 |
| abstract_inverted_index.stiffening. | 44 |
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| abstract_inverted_index.high-density | 33 |
| abstract_inverted_index.hypertension | 41 |
| abstract_inverted_index.inflammation | 10, 24 |
| abstract_inverted_index.inflammatory | 54, 206 |
| abstract_inverted_index.participants | 69 |
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| abstract_inverted_index.high-sensitivity | 94 |
| abstract_inverted_index.hsCRP-to-albumin | 97 |
| abstract_inverted_index.neutrophil/HDL-C | 119, 184, 248 |
| abstract_inverted_index.percentage-to-albumin | 115 |
| abstract_inverted_index.platelet-to-lymphocyte | 108 |
| abstract_inverted_index.neutrophil-to-lymphocyte | 105 |
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| institutions_distinct_count | 6 |
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