JAMA Ophthalmology • Vol 138 • No 10
Associations of Variation in Retinal Thickness With Visual Acuity and Anatomic Outcomes in Eyes With Neovascular Age-Related Macular Degeneration Lesions Treated With Anti–Vascular Endothelial Growth Factor Agents
August 2020 • Rebecca Evans, Barnaby C Reeves, Maureen G. Maguire, Daniel Martín, Alyson Muldrew, Tünde Pető, Chris Rogers, Usha Chakravarthy
Greater variation in retinal thickness in eyes with nAMD during treatment with anti-VEGF was associated with worse BCVA and development of fibrosis and macular atrophy in these post hoc analyses, despite protocol-directed treatment frequency. Practitioners may want to consider variation in retinal thickness when advising patients about their prognosis.