Atheroprotective Effects and Molecular Mechanism of Berberine Article Swipe
Xing Lü
,
Xin Zhou
,
Aihong Li
,
Hui-Jin Li
,
Chun‐Xia He
,
Wei Qin
,
Dong Zhao
,
Peng-Quan Li
,
Li Zhu
,
Hui‐Ling Cao
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fmolb.2021.762673
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fmolb.2021.762673
Cardiovascular diseases remain the leading cause of morbidity and mortality worldwide. Atherosclerosis is the main pathological basis of cardiovascular diseases and it is closely associated with hyperlipidemia, endothelial injury, macrophage-derived foam cells formation, proliferation and migration of vascular smooth muscle cells (VSMCs), platelet aggregation, and altered gut microbiota. Various symptomatic treatments, that are currently used to inhibit atherosclerosis, need to be administered in long term and their adverse effects cannot be ignored. Berberine (BBR) has beneficial effects on atherosclerosis through regulating multiple aspects of its progression. This review highlights the recent advances in understanding the anti-atherosclerosis mechanism of BBR. BBR alleviated atherosclerosis by attenuation of dyslipidemia, correction of endothelial dysfunction, inhibition of macrophage inflammation and foam cell formation, activation of macrophage autophagy, regulation of the proliferation and migration of VSMCs, attenuation of platelet aggregation, and modulation of gut microbiota. This review would provide a modern scientific perspective to further understanding the molecular mechanism of BBR attenuating atherosclerosis and supply new ideas for atherosclerosis management.
Related Topics
Concepts
Berberine
Mechanism (biology)
Inflammation
Dyslipidemia
Macrophage
Hyperlipidemia
Autophagy
Foam cell
Medicine
Platelet activation
Endothelial dysfunction
Pharmacology
Platelet
Cancer research
Immunology
Biology
Diabetes mellitus
Internal medicine
Cholesterol
Lipoprotein
Apoptosis
Endocrinology
Biochemistry
In vitro
Philosophy
Epistemology
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fmolb.2021.762673
- https://www.frontiersin.org/articles/10.3389/fmolb.2021.762673/pdf
- OA Status
- gold
- Cited By
- 20
- References
- 111
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3212805271
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3212805271Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fmolb.2021.762673Digital Object Identifier
- Title
-
Atheroprotective Effects and Molecular Mechanism of BerberineWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
-
2021-11-16Full publication date if available
- Authors
-
Xing Lü, Xin Zhou, Aihong Li, Hui-Jin Li, Chun‐Xia He, Wei Qin, Dong Zhao, Peng-Quan Li, Li Zhu, Hui‐Ling CaoList of authors in order
- Landing page
-
https://doi.org/10.3389/fmolb.2021.762673Publisher landing page
- PDF URL
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https://www.frontiersin.org/articles/10.3389/fmolb.2021.762673/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.frontiersin.org/articles/10.3389/fmolb.2021.762673/pdfDirect OA link when available
- Concepts
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Berberine, Mechanism (biology), Inflammation, Dyslipidemia, Macrophage, Hyperlipidemia, Autophagy, Foam cell, Medicine, Platelet activation, Endothelial dysfunction, Pharmacology, Platelet, Cancer research, Immunology, Biology, Diabetes mellitus, Internal medicine, Cholesterol, Lipoprotein, Apoptosis, Endocrinology, Biochemistry, In vitro, Philosophy, EpistemologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
20Total citation count in OpenAlex
- Citations by year (recent)
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2025: 6, 2024: 6, 2023: 5, 2022: 2, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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111Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.diseases | 1, 19 |
| abstract_inverted_index.ignored. | 71 |
| abstract_inverted_index.multiple | 81 |
| abstract_inverted_index.platelet | 42, 132 |
| abstract_inverted_index.vascular | 37 |
| abstract_inverted_index.Berberine | 72 |
| abstract_inverted_index.currently | 53 |
| abstract_inverted_index.mechanism | 96, 152 |
| abstract_inverted_index.migration | 35, 127 |
| abstract_inverted_index.molecular | 151 |
| abstract_inverted_index.morbidity | 7 |
| abstract_inverted_index.mortality | 9 |
| abstract_inverted_index.activation | 118 |
| abstract_inverted_index.alleviated | 100 |
| abstract_inverted_index.associated | 24 |
| abstract_inverted_index.autophagy, | 121 |
| abstract_inverted_index.beneficial | 75 |
| abstract_inverted_index.correction | 106 |
| abstract_inverted_index.formation, | 32, 117 |
| abstract_inverted_index.highlights | 88 |
| abstract_inverted_index.inhibition | 110 |
| abstract_inverted_index.macrophage | 112, 120 |
| abstract_inverted_index.modulation | 135 |
| abstract_inverted_index.regulating | 80 |
| abstract_inverted_index.regulation | 122 |
| abstract_inverted_index.scientific | 145 |
| abstract_inverted_index.worldwide. | 10 |
| abstract_inverted_index.attenuating | 155 |
| abstract_inverted_index.attenuation | 103, 130 |
| abstract_inverted_index.endothelial | 27, 108 |
| abstract_inverted_index.management. | 163 |
| abstract_inverted_index.microbiota. | 47, 138 |
| abstract_inverted_index.perspective | 146 |
| abstract_inverted_index.symptomatic | 49 |
| abstract_inverted_index.treatments, | 50 |
| abstract_inverted_index.administered | 61 |
| abstract_inverted_index.aggregation, | 43, 133 |
| abstract_inverted_index.dysfunction, | 109 |
| abstract_inverted_index.inflammation | 113 |
| abstract_inverted_index.pathological | 15 |
| abstract_inverted_index.progression. | 85 |
| abstract_inverted_index.dyslipidemia, | 105 |
| abstract_inverted_index.proliferation | 33, 125 |
| abstract_inverted_index.understanding | 93, 149 |
| abstract_inverted_index.Cardiovascular | 0 |
| abstract_inverted_index.cardiovascular | 18 |
| abstract_inverted_index.Atherosclerosis | 11 |
| abstract_inverted_index.atherosclerosis | 78, 101, 156, 162 |
| abstract_inverted_index.hyperlipidemia, | 26 |
| abstract_inverted_index.atherosclerosis, | 57 |
| abstract_inverted_index.macrophage-derived | 29 |
| abstract_inverted_index.anti-atherosclerosis | 95 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5001565009 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 10 |
| corresponding_institution_ids | https://openalex.org/I4210107780 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8600000143051147 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.87794037 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |