Atom Exchange Radical Cyclization: A Sustainable Synthetic Approach towards New Functionalized Targets Article Swipe
Related Concepts
Halogen
Radical cyclization
Combinatorial chemistry
Chemistry
Atom (system on chip)
Atom-transfer radical-polymerization
Photochemistry
Medicinal chemistry
Organic chemistry
Computer science
Embedded system
Polymer
Copolymer
Alkyl
Biagio Anderlini
,
Andrea Severini
,
Camilla Ferrari
,
Claudio Fontanesi
,
Vittorio Ascari
,
Niccolò Braidi
,
Fabrizio Roncaglia
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/app14114357
· OA: W4398206954
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/app14114357
· OA: W4398206954
In this study, we demonstrate the direct preparation of dihalo-γ-lactams featuring two distinct halogens from dichloroamides using a novel atom exchange radical cyclization (AERC) procedure. This method integrates the established atom transfer radical cyclization (ATRC) with halogen exchange in solution. The technique operates under mild conditions and requires small amounts of metallic copper, serving as both a supplemental activator and reducing agent.
Related Topics
Finding more related topics…