Atrophy trajectories in Alzheimer’s disease: how sex matters Article Swipe
Anna Inguanzo
,
Konstantinos Poulakis
,
Javier Oltra
,
Silvia Maioli
,
Anna Marseglia
,
Daniel Ferreira
,
Rosaleena Mohanty
,
Eric Westman
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1186/s13195-025-01713-x
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1186/s13195-025-01713-x
Introduction Longitudinal subtypes in Alzheimer’s disease (AD) have been identified based on their distinct brain atrophy trajectories, encompassing mediotemporal and cortical pathways. These subtypes include minimal atrophy, limbic predominant, limbic predominant plus, diffuse atrophy and hippocampal sparing. The impact of sex on the progression of these subtypes remains a crucial area of investigation. Methods We analysed MRI data from 320 amyloid-β positive individuals with AD from three international cohorts (ADNI, J-ADNI and AIBL). Longitudinal clustering was conducted to identify atrophy trajectories over eight years from the clinical disease onset, with separate trajectories delineated for women and men. Results Women consistently exhibited earlier hippocampal atrophy and a higher burden of white matter abnormalities compared to men, yet women displayed less cognitive decline over time. Additionally, specific risk factors and distinct neuropsychiatric symptoms were associated with sex within specific trajectories. Conclusions AD subtypes show sex-specific differences in disease progression, highlighting the need to account for these differences from the early disease stages. Integrating imaging biomarkers with sex differences can enable the identification of more precise treatments for each patient, ensuring that both women and men have equal access to tailored care.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1186/s13195-025-01713-x
- OA Status
- gold
- Cited By
- 1
- References
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- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W4409358677Canonical identifier for this work in OpenAlex
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https://doi.org/10.1186/s13195-025-01713-xDigital Object Identifier
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Atrophy trajectories in Alzheimer’s disease: how sex mattersWork title
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
- Publication date
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2025-04-11Full publication date if available
- Authors
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Anna Inguanzo, Konstantinos Poulakis, Javier Oltra, Silvia Maioli, Anna Marseglia, Daniel Ferreira, Rosaleena Mohanty, Eric WestmanList of authors in order
- Landing page
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https://doi.org/10.1186/s13195-025-01713-xPublisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1186/s13195-025-01713-xDirect OA link when available
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Atrophy, Neurology, Disease, Medicine, Dementia, Psychology, Internal medicine, Neuroscience, Pathology, OncologyTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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