Attenuation of Immunogenicity in MOG-Induced Oligodendrocytes by the Probiotic Bacterium Lactococcus Sp. PO3 Article Swipe
Ashraf Khalifa
,
Hairul-Islam Mohamed Ibrahim
,
Abdullah Sheikh
,
Hany Ezzat Khalil
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/medicina59101731
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/medicina59101731
Background and Objectives: Milk is healthy and includes several vital nutrients and microbiomes. Probiotics in milk and their derivatives modulate the immune system, fight inflammation, and protect against numerous diseases. The present study aimed to isolate novel bacterial species with probiotic potential for neuroinflammation. Materials and Methods: Six milk samples were collected from lactating dairy cows. Bacterial isolates were obtained using standard methods and were evaluated based on probiotic characteristics such as the catalase test, hemolysis, acid/bile tolerance, cell adhesion, and hydrophobicity, as well as in vitro screening. Results: Nine morphologically diverse bacterial isolates were found in six different types of cow’s milk. Among the isolates, PO3 displayed probiotic characteristics. PO3 was a Gram-positive rod cell that grew in an acidic (pH-2) salty medium containing bile salt and salinity (8% NaCl). PO3 also exhibited substantial hydrophobicity and cell adhesion. The sequencing comparison of the 16S rRNA genes revealed that PO3 was Lactococcus raffinolactis with a similarity score of 99.3%. Furthermore, PO3 was assessed for its neuroanti-inflammatory activity on human oligodendrocyte (HOG) cell lines using four different neuroimmune markers: signal transducer and activator of transcription (STAT-3), myelin basic protein (MBP), glial fibrillary acidic protein (GFAP), and GLAC in HOG cell lines induced by MOG. Unlike the rest of the evaluated neuroimmune markers, STAT-3 levels were elevated in the MOG-treated HOG cell lines compared to the untreated ones. The expression level of STAT-3 was attenuated in both PO3-MOG-treated and only PO3-treated cell lines. On the contrary, in PO3-treated cell lines, MBP, GFAP, and GLAC were significantly expressed at higher levels when compared with the MOG-treated cell lines. Conclusions: The findings reported in this article are to be used as a foundation for further in vivo research in order to pave the way for the possible use of probiotics in the treatment of neuroinflammatory diseases, including multiple sclerosis.
Related Topics
Concepts
Probiotic
Microbiology
Biology
Immunogenicity
Lactococcus lactis
Hemolysis
Bacteria
Immune system
Immunology
Lactic acid
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/medicina59101731
- https://www.mdpi.com/1648-9144/59/10/1731/pdf?version=1695883092
- OA Status
- gold
- Cited By
- 2
- References
- 57
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4387097167
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4387097167Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/medicina59101731Digital Object Identifier
- Title
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Attenuation of Immunogenicity in MOG-Induced Oligodendrocytes by the Probiotic Bacterium Lactococcus Sp. PO3Work title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-09-27Full publication date if available
- Authors
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Ashraf Khalifa, Hairul-Islam Mohamed Ibrahim, Abdullah Sheikh, Hany Ezzat KhalilList of authors in order
- Landing page
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https://doi.org/10.3390/medicina59101731Publisher landing page
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https://www.mdpi.com/1648-9144/59/10/1731/pdf?version=1695883092Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1648-9144/59/10/1731/pdf?version=1695883092Direct OA link when available
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Probiotic, Microbiology, Biology, Immunogenicity, Lactococcus lactis, Hemolysis, Bacteria, Immune system, Immunology, Lactic acid, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 1Per-year citation counts (last 5 years)
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57Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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